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First exposure to rituximab is associated to high rate of anti-drug antibodies in systemic lupus erythematosus but not in ANCA-associated vasculitis

Autor: Malin Ryner, Iva Gunnarsson, Anna Fogdell-Hahn, Nastya Kharlamova, F. Faustini, Vivianne Malmström, Annette Bruchfeld, Nicky Dunn

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Arthritis Research & Therapy

Background Anti-drug antibodies (ADAs) can impact on the efficacy and safety of biologicals, today used to treat several chronic inflammatory conditions. Specific patient groups may be more prone to develop ADAs. Rituximab is routinely used for ANCA-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c542232bbb4aa683f8e68a56662231c
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-178466

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A phase I pharmacokinetics trial comparing PF-05280586 (a potential biosimilar) and rituximab in patients with active rheumatoid arthritis

Autor: Jean‐Claude Becker, Donghua Yin, Stanley N. Cohen, George Spencer‐Green, Maria Greenwald, Barry Gumbiner, Paul Emery, Xu Meng, L.A. Melia, Dolca Thomas, Ruifeng Li

Publikováno v: British Journal of Clinical Pharmacology

Aims: Pharmacokinetic (PK) similarity was assessed among PF‐05280586 (a proposed biosimilar) vs. rituximab sourced from the European Union (rituximab‐EU) and the United States (rituximab‐US). Pharmacodynamics (PD), overall safety and immunogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6117bcd7b0fb35d702c2de924f83747
https://pubmed.ncbi.nlm.nih.gov/26909489

Low circulating B cells in immunocompromised individuals are linked to poorer antibody responses to vaccines and a predisposition to viral infections.

Autor: Grammatikos A; Bristol Immunology and Allergy Centre, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom., Moghaddas F; Bristol Immunology and Allergy Centre, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom., Reeve H; School of Mathematics, University of Bristol, Bristol, United Kingdom., Johnston S; Bristol Immunology and Allergy Centre, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom., Gompels M; Bristol Immunology and Allergy Centre, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom., Albur M; Bristol Centre for Antimicrobial Research and Evaluation, North Bristol NHS Trust, Bristol, United Kingdom.

Publikováno v: The journal of allergy and clinical immunology. Global [J Allergy Clin Immunol Glob] 2022 Sep 22; Vol. 2 (1), pp. 111-113. Date of Electronic Publication: 2022 Sep 22 (Print Publication: 2023).