Zobrazeno 1 - 10
of 933
pro vyhledávání: '"B YATES"'
Autor:
Azucena Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott, Julia Fröse, Daniel Goulet, Khloe S. Gordon, Keith P. Eidell, Paul Leclerc, Charles A. Whittaker, Rebecca C. Larson, Audrey J. Muscato, Kathleen B. Yates, Juan Dubrot, John G. Doench, Aviv Regev, Matthew G. Vander Heiden, Marcela V. Maus, Robert T. Manguso, Michael E. Birnbaum, Michael T. Hemann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of CAR-T cells and antigen escape. To investigate leukemia-intrinsic CAR-T resistance mec
Externí odkaz:
https://doaj.org/article/6711e44bcbe14aeaa34f0e56893dd8c0
Autor:
J. Bryan Iorgulescu, Neil Ruthen, Ryuhjin Ahn, Eleni Panagioti, Prafulla C. Gokhale, Martha Neagu, Maria C. Speranza, Benjamin K. Eschle, Kara M. Soroko, Raziye Piranlioglu, Meenal Datta, Shanmugarajan Krishnan, Kathleen B. Yates, Gregory J. Baker, Rakesh K. Jain, Mario L. Suvà, Donna Neuberg, Forest M. White, E. Antonio Chiocca, Gordon J. Freeman, Arlene H. Sharpe, Catherine J. Wu, David A. Reardon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct differences in their responses to immunotherapy.MethodsTo decipher the cell-intri
Externí odkaz:
https://doaj.org/article/0d4ef411871943b490bc6d2c4f558fb2
Autor:
Chirag Patel, Meng Sun, Yue Liu, Jonathan Powell, Kyle Halliwill, Jennifer M Frost, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Keith M Hamel, Kira Olander, Kathleen A McGuire, Audrey J Muscato, Kelly Klinge, Joseph Klahn, Jacqueline Aguado, Payal Tiwari, Kayla J Colvin, Marcia N Paddock, Philip R Kym, Omar Avila-Monge, Alexander Schutte
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/91cbd5f2b1c44b56be7bd4787add03a6
Autor:
Wei Qiu, Qi Sun, Yi Yang, Chirag Patel, Meng Sun, Yue Liu, Kyle Halliwill, Sarah Kim, Rebecca Mathew, Jennifer M Frost, Jennifer A Roth, Domenick Kennedy, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Arvin Iracheta-Vellve, Keith M Hamel, Kira Olander, Thomas GR Davis, Kathleen A McGuire, Geoff T Halvorsen, Omar I Avila, Ashwin V Kammula, Audrey J Muscato, Prasanthi Geda, Kelly Klinge, Zhaoming Xiong, Ryan Duggan, Liang Mu, Mitchell D Yeary, James C Patti, Tyler M Balon, Carey Backus, Angeline Chen, Kenton Longenecker, Joseph Klahn, Cara Hrusch, Navasona Krishnan, Charles W Hutchins, Jacqueline Aguado, Marinka Bulic, Payal Tiwari, Kayla J Colvin, Cun Lan Chuong, Ian C Kohnle, Matthew G Rees, Andrew Boghossian, Melissa Ronan, Meng-Ju Wu, Debattama R Sen, Gabriel K Griffin, Nabeel El-Bardeesy, Patricia Trusk, Joshua H Decker, Stacey Fossey, Marcia N Paddock, Elliot P Farney, Clay Beauregard, Philip R Kym
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/11356ff1bf1f4b63ab1324cafa253315
Autor:
Debjani Pal, Kuntal De, Carly M. Shanks, Kai Feng, Timothy B. Yates, Jennifer Morrell-Falvey, Russell B. Davidson, Jerry M. Parks, Wellington Muchero
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are essential for HGF/c-MET signaling and regulate their interaction, perinuclear localization, and cellular internalization. Thus, targeting PAN may represent a mechanism for the
Externí odkaz:
https://doaj.org/article/6723ce81c6c14178bfb99e772c5987d5
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106274- (2023)
Summary: The global pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has become a severe global health problem because of its rapid spread. Both Ace2 and NRP1 provide initial viral bind
Externí odkaz:
https://doaj.org/article/777642b625014d7d8f47827f30b955e7
Autor:
Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Sarah Y. Kim, John G. Doench, Kathleen B. Yates, Robert T. Manguso, Juan Dubrot
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102082- (2023)
Summary: Recognition of Cas9 and other proteins encoded in delivery vectors has limited CRISPR technology in vivo. Here, we present a protocol for genome engineering using selective CRISPR antigen removal (SCAR) lentiviral vectors in Renca mouse mode
Externí odkaz:
https://doaj.org/article/0c320af4e9ac4ab5a03b47a82bf988de
Autor:
Yashaswi Shrestha, Michael Quigley, Travis Hughes, Robert T Manguso, Natalie B Collins, Rose Al Abosy, Brian C Miller, Kevin Bi, Qihong Zhao, Jeffrey J Ishizuka, Kathleen B Yates, Hans W Pope, Marc Wadsworth, Alex K Shalek, Jesse S Boehm, William C Hahn, John G Doench, W Nicholas Haining
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Oncogenes act in a cell-intrinsic way to promote tumorigenesis. Whether oncogenes also have a cell-extrinsic effect on suppressing the immune response to cancer is less well understood.Methods We use an in vivo expression screen of known c
Externí odkaz:
https://doaj.org/article/2f18639e65804873a00ab93aef07c6bc
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Autor:
Martin W. LaFleur, Thao H. Nguyen, Matthew A. Coxe, Kathleen B. Yates, Justin D. Trombley, Sarah A. Weiss, Flavian D. Brown, Jacob E. Gillis, Daniel J. Coxe, John G. Doench, W. Nicholas Haining, Arlene H. Sharpe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The use of functional genomics in primary immune cells has been limited by inefficient vector delivery and risk of perturbing cell states. Here the authors present CHimeric IMmune Editing (CHIME) for in vivo evaluation of gene function and pooled scr
Externí odkaz:
https://doaj.org/article/f4cc26f0a06e487587662b0cfb8d4512