Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy

Autor: Genevieve E. Martin, Debattama R. Sen, Matthew Pace, Nicola Robinson, Jodi Meyerowitz, Emily Adland, John P. Thornhill, Mathew Jones, Ane Ogbe, Lucia Parolini, Natalia Olejniczak, Panagiota Zacharopoulou, Helen Brown, Christian B. Willberg, Nneka Nwokolo, Julie Fox, Sarah Fidler, W. Nicholas Haining, John Frater

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

T cell dysfunction occurs early following HIV infection, impacting the emergence of non-AIDS morbidities and limiting curative efforts. ART initiated during primary HIV infection (PHI) can reverse this dysfunction, but the extent of recovery is unkno

Externí odkaz: https://doaj.org/article/3d165a2ffd8b4a029910eb0c288ef7ef

MAIT cells are activated during human viral infections

Autor: Bonnie van Wilgenburg, Iris Scherwitzl, Edward C. Hutchinson, Tianqi Leng, Ayako Kurioka, Corinna Kulicke, Catherine de Lara, Suzanne Cole, Sirijitt Vasanawathana, Wannee Limpitikul, Prida Malasit, Duncan Young, Laura Denney, STOP-HCV consortium, Michael D. Moore, Paolo Fabris, Maria Teresa Giordani, Ye Htun Oo, Stephen M. Laidlaw, Lynn B. Dustin, Ling-Pei Ho, Fiona M. Thompson, Narayan Ramamurthy, Juthathip Mongkolsapaya, Christian B. Willberg, Gavin R. Screaton, Paul Klenerman

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing int

Externí odkaz: https://doaj.org/article/cc3459afe5a047aa8c5feb665511a1eb

CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells

Autor: Ayako Kurioka, Cormac Cosgrove, Yannick Simoni, Bonnie van Wilgenburg, Alessandra Geremia, Sophia Björkander, Eva Sverremark-Ekström, Christine Thurnheer, Huldrych F. Günthard, Nina Khanna, The Swiss HIV Cohort Study, Oxford IBD Cohort Investigators, Lucy Jane Walker, Carolina V. Arancibia-Cárcamo, Evan W. Newell, Christian B. Willberg, Paul Klenerman, V Aubert, M Battegay, E Bernasconi, J Böni, DL Braun, HC Bucher, C Burton-Jeangros, A Calmy, M Cavassini, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, CA Fux, M Gorgievski, H Günthard, D Haerry, B Hasse, HH Hirsch, M Hoffmann, I Hösli, C Kahlert, L Kaiser, O Keiser, T Klimkait, R Kouyos, H Kovari, B Ledergerber, G Martinetti, B Martinez de Tejada, C Marzolini, K Metzner, N Müller, D Nadal, D Nicca, G Pantaleo, A Rauch, S Regenass, C Rudin, A Scherrer, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, P Vernazza, R Weber, S Yerly, CV Arancibia-Cárcamo, A Bailey, E Barnes, B Bird-Lieberman, O Brain, B Braden, J Collier, J East, A Geremia, L Howarth, S Keshav, P Klenerman, S Leedham, R Palmer, F Powrie, A Rodrigues, A Simmons, P Sullivan, SPL Travis, H Uhlig

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a

Externí odkaz: https://doaj.org/article/bee5ae2e92974efa8bf3cec10af3c162

CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages

Autor: Joannah R. Fergusson, Kira E. Smith, Vicki M. Fleming, Neil Rajoriya, Evan W. Newell, Ruth Simmons, Emanuele Marchi, Sophia Björkander, Yu-Hoi Kang, Leo Swadling, Ayako Kurioka, Natasha Sahgal, Helen Lockstone, Dilair Baban, Gordon J. Freeman, Eva Sverremark-Ekström, Mark M. Davis, Miles P. Davenport, Vanessa Venturi, James E. Ussher, Christian B. Willberg, Paul Klenerman

Publikováno v: Cell Reports, Vol 9, Iss 3, Pp 1075-1088 (2014)

The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant T (MAIT) cells. To understand whether different T cell subsets expressing CD161 have simil

Externí odkaz: https://doaj.org/article/57d31d0d22244028a7c3bf0b0d58fcc2

Expression of lectin-like transcript-1 in human tissues [version 1; referees: 1 approved, 2 approved with reservations]

Autor: Alba Llibre, Lucy Garner, Amy Partridge, Gordon J. Freeman, Paul Klenerman, Chris B. Willberg

Publikováno v: F1000Research, Vol 5 (2016)

Background: Receptor-ligand pairs of C-type lectin-like proteins have been shown to play an important role in cross talk between lymphocytes, as well as in immune responses within concrete tissues and structures, such as the skin or the germinal cent

Externí odkaz: https://doaj.org/article/ccf93d06167f4c92812656a451d79093