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Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?

Autor: Jean Claude Reubi, Hanwen Zhang, Mihaela Ginj, B. Waser, Helmut R. Maecke, Richard P. Baum, Patricia Antunes

Publikováno v: Antunes, P; Ginj, M; Zhang, H; Waser, B; Baum, R P; Reubi, J. C.; Maecke, H (2007). Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? European journal of nuclear medicine and molecular imaging, 34(7), pp. 982-93. Berlin: Springer 10.1007/s00259-006-0317-x

PURPOSE: Gallium-68 is a metallic positron emitter with a half-life of 68 min that is ideal for the in vivo use of small molecules, such as [68Ga-DOTA,Tyr3]octreotide, in the diagnostic imaging of somatostatin receptor-positive tumours. In preclinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162e91247b8122cda978bf45b3cd0228
http://doc.rero.ch/record/320185/files/259_2006_Article_317.pdf

Highly Efficient In Vivo Agonist-Induced Internalization of sst2 Receptors in Somatostatin Target Tissues

Autor: Renzo Cescato, B. Waser, Helmut R. Maecke, Jean Claude Reubi, Maria-Luisa Tamma

Publikováno v: Journal of Nuclear Medicine. 50:936-941

The successful peptide receptor imaging of tumors, as exemplified for somatostatin receptors, is based on the overexpression of peptide receptors in selected tumors and the high-affinity binding to these tumors of agonist radioligands that are subseq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbd1eb699c45a4598812ff6d831b922
https://doi.org/10.2967/jnumed.108.061457

Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice

Autor: Brigitta M. Peskar, Diana Schmassmann-Suhijar, Jean Claude Reubi, A. Schmassmann, B. Waser, Jan-Olaf Gebbers, Georg Zoidl

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 290:G747-G756

Traditional NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, and inhibitors of nitric oxide synthase (NOS) impair the healing of preexisting gastric ulcers. However, the role of COX-1 (with or without impairment of COX-2) and the interaction betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef283585ffbef3908a53402633f5725
https://doi.org/10.1152/ajpgi.00416.2005

Immunohistochemical Localization of Somatostatin Receptor sst2A in Human Gut and Lung Tissue: Possible Implications for Physiology and Carcinogenesis

Autor: Jean Claude Reubi, Mathias Gugger, Agnes Schonbrunn, B. Waser, Andreas Kappeler

Publikováno v: Annals of the New York Academy of Sciences. 1014:132-136

Many neuroendocrine gastrointestinal and lung tumors express sst2A somatostatin receptors. Because the cellular location of sst2A in the corresponding non-neoplastic tissue is unknown, we searched for sst2A immuno-reactive cells and characterized the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315a7e38789489c808e822e92618c159
https://doi.org/10.1196/annals.1294.013