Zobrazeno 1 - 10
of 317
pro vyhledávání: '"B W Glickman"'
Publikováno v:
Canadian family physician Medecin de famille canadien. 34
Molecular biology and recombinant DNA technology are beginning to have an effect on the medical health care field, particularly in the area of clinical genetics. Dramatic improvements in the prerequisite technology are in the process of being transfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e29f6687dd354bc7051c890f2d0944d9
https://pubmed.ncbi.nlm.nih.gov/21253094
https://pubmed.ncbi.nlm.nih.gov/21253094
Publikováno v:
Genetics. 132:911-927
We have examined the mutational specificity of 1-nitroso-8-nitropyrene (1,8-NONP), an activated metabolite of the carcinogen 1,8-dinitropyrene, in the lacI gene of Escherichia coli strains which differ with respect to nucleotide excision repair (+/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb14165532133049f4f2668023792b2
https://doi.org/10.1093/genetics/132.4.911
https://doi.org/10.1093/genetics/132.4.911
Publikováno v:
Journal of Biological Chemistry. 266:11766-11773
An approach utilizing fluorescence-activated DNA sequencing technology was used to study the position and frequency of UV-induced lesions in the lacI gene of Escherichia coli. The spectrum of sites of UV damage in the NC+ region of the gene was compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bcf39a09240d7e3e501259982c6592d
https://doi.org/10.1016/s0021-9258(18)99023-x
https://doi.org/10.1016/s0021-9258(18)99023-x
Publikováno v:
Environmental and molecular mutagenesis. 36(3)
A significant fraction of human cancers are thought to have a genetic component and several lines of evidence suggest that deficiencies in DNA repair may be a contributing factor. Little is known, however, about the frequency and distribution of vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d252749cdfbd01dbf18e9b71a1ba1217
https://pubmed.ncbi.nlm.nih.gov/11044904
https://pubmed.ncbi.nlm.nih.gov/11044904
Publikováno v:
Environmental and molecular mutagenesis. 36(3)
Genotoxic stresses induce cellular responses that can be observed at the level of gene expression. We have studied changes in gene expression following BPDE exposure in HeLa cells by using a cDNA expression array of 597 human genes. After a 53-hr exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c201dcc3f70ccf69c69cecf4a92797f6
https://pubmed.ncbi.nlm.nih.gov/11044901
https://pubmed.ncbi.nlm.nih.gov/11044901
Publikováno v:
Environmental and molecular mutagenesis. 36(1)
Tris(2,3-dibromopropyl)phosphate (TDBP) is a kidney carcinogen in rats in which exposure results in tumors specifically in the outer medulla. We have previously shown that TDBP induces mutation in the rat kidney. Here we demonstrate that TDBP induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08d5193dc0d1d50aa6f81ffe9d8737f8
https://pubmed.ncbi.nlm.nih.gov/10918353
https://pubmed.ncbi.nlm.nih.gov/10918353
Publikováno v:
Human mutation. 15(5)
It has been previously noted that the hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutant frequency of Russian subjects is significantly higher than age-matched Western counterparts. To further explore this difference, approximately 100 muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7797761289e657474a9d9d8b81bbad32
https://pubmed.ncbi.nlm.nih.gov/10790205
https://pubmed.ncbi.nlm.nih.gov/10790205
Autor:
J A, Heddle, S, Dean, T, Nohmi, M, Boerrigter, D, Casciano, G R, Douglas, B W, Glickman, N J, Gorelick, J C, Mirsalis, H J, Martus, T R, Skopek, V, Thybaud, K R, Tindall, N, Yajima
Publikováno v:
Environmental and molecular mutagenesis. 35(3)
Transgenic rodent gene mutation models provide quick and statistically reliable assays for mutations in the DNA from any tissue. For regulatory applications, assays should be based on neutral genes, be generally available in several laboratories, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e02719958bc93ea898d15766add41be
https://pubmed.ncbi.nlm.nih.gov/10737959
https://pubmed.ncbi.nlm.nih.gov/10737959
Publikováno v:
Cancer research. 60(2)
Male lacl transgenic rats were fed a diet containing 200 ppm of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine present in cooked meats. PhIP was found to be a powerful prostate mutagen. After 61 days of treatment, the la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c675615a8b97f871f2f2bf0800c20709
https://pubmed.ncbi.nlm.nih.gov/10667573
https://pubmed.ncbi.nlm.nih.gov/10667573
Publikováno v:
Environmental and molecular mutagenesis. 34(2-3)
We determined the spectrum of mutations in the lacI gene in the liver of Big Blue(R) transgenic mice after exposure to five daily doses of 2 mg/kg dimethylnitrosamine (DMN) at 3 and 6 weeks of age. This dose has been reported to increase the mutant f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4000305ebed00b74bc4146748b823085
https://pubmed.ncbi.nlm.nih.gov/10529729
https://pubmed.ncbi.nlm.nih.gov/10529729