Zobrazeno 1 - 10 of 73 pro vyhledávání: '"B W Fox"'
1
Evaluation of rodent-only toxicology for early clinical trials with novel cancer therapeutics
Autor: Duncan I. Jodrell, B W Fox, David Richard Newell, S S Burtles, T A Connors
Publikováno v: British Journal of Cancer
Preclinical toxicology studies are performed prior to phase I trials with novel cancer therapeutics to identify a safe clinical starting dose and potential human toxicities. The primary aim of this study was to evaluate the ability of rodent-only tox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d77c63a1745c3430ac66cceab350a6
https://doi.org/10.1038/sj.bjc.6690761
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2
Relationships between ablation of distinct haematopoietic cell subsets and the development of donor bone marrow engraftment following recipient pretreatment with different alkylating drugs
Autor: R. E. Ploemacher, JH Dillingh, JD Down, B. W. Fox, A Boudewijn
Publikováno v: British Jounal of Cancer, 70(4), 611-616. Nature Publishing Group
British Journal of Cancer
A number of different alkylating chemotherapeutic agents - busulphan, dimethylbusulphan (DMB), isopropylmethane sulphonate (IMS), melphalan, cyclophosphamide (CY) and bischloroethylnitrosourea (BCNU)- were investigated for their cytotoxic effects on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f62234b0d7e76efe6b658afe345486
https://research.rug.nl/en/publications/0ff4a922-2790-4c7d-a125-f83246f5e111
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3
DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates
Autor: Robert L. Souhami, Mauro Ponti, B. W. Fox, John A. Hartley
Publikováno v: British Journal of Cancer
Members of the homologous series of alkanediol dimethanesulphonates of general formula H3C.SO2O.(CH2)n.O.SO2.CH3 have been tested for their ability to produce DNA interstrand crosslinking and DNA sequence selectivity of guanine-N7 alkylation. In a se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65edf56eadbe72b4b1f50d706360fb1f
https://doi.org/10.1038/bjc.1991.166
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5
Dimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus
Autor: J A, Hadfield, B W, Fox, R, Caffrey
Publikováno v: Anti-cancer drug design. 7(3)
The antitumour activities of 15 novel aromatic dimethanesulphonate esters were studied. Several alkyl and alkoxy compounds have shown good antitumour activity whilst similar isomers have proved ineffective as antitumour agents. These differences in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6f97aa0bee908d4fa05afcacd3787b7
https://pubmed.ncbi.nlm.nih.gov/1610483
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6
Dimethanesulphonate esters in receptor mapping studies. 1. Benzene 1,2-, 1,3- and 1,4-diol, dimethanol and diethanol dimethanesulphonates and anti-tumour activity
Autor: B W, Fox, J A, Hadfield, P M, O'Connor
Publikováno v: Anti-cancer drug design. 6(2)
The anti-tumour activities of nine aromatic dimethanesulphonate esters were examined. Their biological effects have been related to both their chemical reactivity and to the computer-modelled vectorial positions of the centres of alkylation of the co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6ab12f2b2fca15efd2ca5d4cb1cf5bb
https://pubmed.ncbi.nlm.nih.gov/2039583
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7
Isolation and Characterization of Proteins Cross-linked to DNA by the Antitumor Agent Methylene Dimethanesulfonate and its Hydrolytic Product Formaldehyde
Autor: P M O'Connor, B W Fox
Publikováno v: Journal of Biological Chemistry. 264:6391-6397
This study attempted to characterize proteins cross-linked to DNA of Yoshida lymphosarcoma cells treated with methylene dimethanesulfonate (MDMS) and its hydrolytic products formaldehyde (HCHO) and methanesulfonic acid (MSA). MDMS and HCHO treatments
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::854a5530baeb2de2cbe8948b98294813
https://doi.org/10.1016/s0021-9258(18)83362-2
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9
The Lichen Flora of a High-Level Limestone-Epidiorite Outcrop in the Ben Alder Range, Scotland
Autor: O. W. Purvis, O. L. Gilbert, B. W. Fox
Publikováno v: The Lichenologist. 14:165-174
The lichen flora of a very small, but outstandingly rich, outcrop of limestone and epidiorite at 1030 m in the Ben Alder range is described. One hundred and six calcicolous species were encountered, many of which are rare nationally; eight are not kn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::324f4926493b0f211dc54550b988192d
https://doi.org/10.1017/s0024282982000309
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10
Lichens of High Ground in the Cairngorm Mountains, Scotland
Autor: B. W. Fox, O. L. Gilbert
Publikováno v: The Lichenologist. 17:51-66
A description and ecological interpretation of lichen communities occurring on high ground in the Cairngorms is presented. The area supports only a limited lichen flora but it is highly specialised; a quarter of the 134 species encountered are though
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fae6fe0b4c565ec601ed019e8866750
https://doi.org/10.1017/s002428298500007x
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