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Familial deficiency of vitamin K-dependent clotting factors

Autor: B W, Weston, P E, Monahan

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 14(6)

Combined deficiency of vitamin K-dependent clotting factors II, VII, IX and X (and proteins C, S, and Z) is usually an acquired clinical problem, often resulting from liver disease, malabsorption, or warfarin overdose. A rare inherited form of defect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a56fb0bcd76458fb3450d15c7a9917d
https://pubmed.ncbi.nlm.nih.gov/19141161

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Transfection of alpha(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells

Autor: K M, Hiller, J P, Mayben, K M, Bendt, G A, Manousos, K, Senger, H S, Cameron, B W, Weston

Publikováno v: Molecular carcinogenesis. 27(4)

Sialyl Lewis x and sialyl Lewis a are oncodevelopmental antigens involved in the pathogenesis of colon adenocarcinoma. Biosynthesis of these glycans is controlled by alpha(1,3/1,4)fucosyltransferases. We report the disruption of sialyl Lewis x/a bios

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ecf5377c984b8e779a068f1311be3d8
https://pubmed.ncbi.nlm.nih.gov/10747292

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Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells

Autor: B W, Weston, K M, Hiller, J P, Mayben, G A, Manousos, K M, Bendt, R, Liu, J C, Cusack

Publikováno v: Cancer research. 59(9)

The initial steps of leukocyte and tumor cell adhesion involve selectin receptor/ligand interactions. The selectin ligand components sialyl Lewis x and sialyl Lewis a are oncodevelopmental antigens involved in progression of adenocarcinoma. Interrupt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1bbe7956913681a37803d43ce25f39a
https://pubmed.ncbi.nlm.nih.gov/10232599

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Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms

Autor: H S, Cameron, D, Szczepaniak, B W, Weston

Publikováno v: The Journal of biological chemistry. 270(34)

The human alpha(1,3)-fucosyltransferase genes FUT3, FUT5, and FUT6 form a cluster on chromosome 19p13.3. Expression was studied using reverse transcriptase-polymerase chain reaction, rapid amplification of cDNA ends, and Northern analyses. FUT3 and F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f6fc9aa09c09d3534a4a8ca8762b6c0
https://pubmed.ncbi.nlm.nih.gov/7650030

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Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees

Autor: R, Mollicone, I, Reguigne, R J, Kelly, A, Fletcher, J, Watt, S, Chatfield, A, Aziz, H S, Cameron, B W, Weston, J B, Lowe

Publikováno v: The Journal of biological chemistry. 269(33)

The Le(a) and Le(b) human blood group antigens are synthesized in tissues producing exocrine secretions; they also circulate in plasma, where they are adsorbed by erythrocytes. They are synthesized by two fucosyltransferases, encoded by Lewis (FUT3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b4a256583437e30c7cc51de95e8c1859
https://pubmed.ncbi.nlm.nih.gov/8063716

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Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6)

Autor: R, Mollicone, I, Reguigne, A, Fletcher, A, Aziz, M, Rustam, B W, Weston, R J, Kelly, J B, Lowe, R, Oriol

Publikováno v: The Journal of biological chemistry. 269(17)

While most humans express an alpha(1,3)-fucosyltransferase in plasma, 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of these plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis neg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::879ce04ef7199a5174dbd1d68366fe9f
https://pubmed.ncbi.nlm.nih.gov/8175676

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Molecular basis for Lewis alpha (1, 3/1, 4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees

Autor: R.J. Kelly, B. W. Weston, A. Fletcher, J.B. Lowe, J. Watt, S. Chatfield, H.S. Cameron, Rosella Mollicone, Auda Aziz, I. Reguigne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2a7cd94e026b447fabadb837e85000

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Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes

Autor: B W, Weston, P L, Smith, R J, Kelly, J B, Lowe

Publikováno v: The Journal of biological chemistry. 267(34)

We and others have previously described the isolation of three human alpha (1,3)fucosyltransferase genes which form the basis of a nascent glycosyltransferase gene family. We now report the molecular cloning and expression of a fourth homologous huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::752004e61a8e90d1156b873b25cf211c
https://pubmed.ncbi.nlm.nih.gov/1339443

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Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities

Autor: B W, Weston, R P, Nair, R D, Larsen, J B, Lowe

Publikováno v: The Journal of biological chemistry. 267(6)

Biochemical and genetic evidence indicates that the human genome may encode four or more distinct GDP-fucose:beta-D-N-acetylglucosaminide 3-alpha-L-fucosyltransferase (alpha(1,3)fucosyltransferase) activities. Genes encoding two of these activities h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a651fb81d7fb2f82340f5e6085a86af
https://pubmed.ncbi.nlm.nih.gov/1740457

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