Zobrazeno 1 - 9 of 9 pro vyhledávání: '"B W, Surber"'
1
Measurement of Liver Microsomal Cytochrome P450 (CYP2D6) Activity Using [O-methyl-14C] Dextromethorphan
Autor: B. Thomekromer, J.T. Uchic, G.A. Rotert, G. Michel, B W Surber, A D Rodrigues, S.B. Thomas, J M Machinist, M J Kukulka
Publikováno v: Analytical Biochemistry. 219:309-320
The activity of human liver microsomal cytochrome P4502D6 (CYP2D6) is readily estimated by following the O-demethylation of [O-methyl-14C]dextromethorphan. The basis of the assay is the quantitative measurement of [14C]formaldehyde (0.05-4.0 microM)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fabc9c1637add865d9d97e8dbee5884
https://doi.org/10.1006/abio.1994.1271
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2
Use of an inverse agonist radioligand [3H]A-317920 reveals distinct pharmacological profiles of the rat histamine H3 receptor
Autor: Y. L. Bennani, S. Cassar, David G. Witte, T. L. Carr, Ramin Faghih, A. A. Hancock, T. A. Esbenshade, B. Bei Yao, C. H. Kang, Thomas R. Miller, B. W. Surber
Publikováno v: Neuropharmacology. 50(4)
Selective radioligands for histamine H(3) receptors have been used to characterize H(3) receptor pharmacology by radioligand binding assays and to determine H(3) receptor distribution by tissue autoradiography. Here we report the synthesis and recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b7ac65bdd965342838f96543ba95c3
https://pubmed.ncbi.nlm.nih.gov/16316670
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3
Identification of the human liver cytochrome P450 enzymes involved in the in vitro metabolism of a novel 5-lipoxygenase inhibitor
Autor: J M, Machinist, M D, Mayer, E M, Roberts, B W, Surber, A D, Rodrigues
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 26(10)
In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) forms involved in the oxidative metabolism of [14C]ABT-761 and its N-dehydroxylated metabolite, [14C]ABT-438, by human liver microsomes. The two compounds were metabolized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79cb509ed8beaf3be8f1f94fce6e58d1
https://pubmed.ncbi.nlm.nih.gov/9763401
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4
[O-ethyl 14C]phenacetin O-deethylase activity in human liver microsomes
Autor: A D, Rodrigues, B W, Surber, Y, Yao, S L, Wong, E M, Roberts
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(9)
The activity of human liver microsomal cytochrome P450 1A2 (CYP1A2) is readily estimated by following the O-deethylation of [O-ethyl 14C]phenacetin (PODase). The basis of the assay is the quantitative measurement of [14C]acetaldehyde, remaining in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::722473a377d61f1821251fceda6a6f84
https://pubmed.ncbi.nlm.nih.gov/9311627
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5
Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans
Autor: J F, Denissen, B A, Grabowski, M K, Johnson, A M, Buko, D J, Kempf, S B, Thomas, B W, Surber
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(4)
The metabolism and disposition of [14C]ritonavir (ABT-538, NOR-VIR), a potent, orally active HIV-1 protease inhibitor, were investigated in male and female Sprague-Dawley rats, beagle dogs, and HIV-negative male human volunteers. Rats and dogs receiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a9ff870dc1282e587403c00d33b2742
https://pubmed.ncbi.nlm.nih.gov/9107549
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7
In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices
Autor: A D, Rodrigues, D J, Mulford, R D, Lee, B W, Surber, M J, Kukulka, J L, Ferrero, S B, Thomas, M S, Shet, R W, Estabrook
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(7)
The metabolism of terfenadine was studied with a cDNA-expressed/purified recombinant fusion protein containing human liver microsomal cytochrome P4503A4 (CYP3A4) linked to rat NADPH-P450 reductase (rF450[mHum3A4/mRatOR]L1) and was compared with that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b78a3cf5634588ff4cfca100165bfc3
https://pubmed.ncbi.nlm.nih.gov/7587966
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8
The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans
Autor: A D, Rodrigues, J L, Ferrero, M T, Amann, G A, Rotert, S P, Cepa, B W, Surber, J M, Machinist, N R, Tich, J P, Sullivan, D S, Garvey
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 22(5)
The metabolism of the cholinergic channel activator [3H]ABT-418 was studied in 9,000g supernatant (S-9) fractions and precision-cut tissue slices prepared from rat, dog, monkey, and human livers. In rat S-9 fractions and tissue slices, the lactam and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38c4cff4228f63c5dce6d357613143e6
https://pubmed.ncbi.nlm.nih.gov/7530622
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