Associations of genetic scores for birth weight with newborn size and later anthropometric traits and cardiometabolic risk markers in South Asians

Autor: Rachel M. Freathy, Akhtar Hussain, Ghattu V. Krishnaveni, Akshay Dedaniya, Alagu Sankareswaran, B W Ogunkolade, Murali Krishna, Bridget A. Knight, Graham A. Hitman, Giriraj R. Chandak, Robin N Beaumont, Sirajul A Sahariah, Ramesh D. Potdar, Kalyanaraman Kumaran, Abdul Kalam A Khan, Chiara Di Gravio, Andrew R. Wood, Sarah Finer, Zahid Hassan, Biswajit W Bhowmik, Suraj S. Nongmaithem, Timothy M. Frayling, Chittaranjan S. Yajnik, Inder D Mali, Caroline H.D. Fall

We recently reported genetic variants associated with birth weight and their effect on future cardiometabolic risk in Europeans. Despite a higher burden of low birth weight and cardiometabolic disorders, such studies are lacking in South Asians. We g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e503b683019a953af361d667f10e9101
https://doi.org/10.21203/rs.3.rs-347804/v1

Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians

Autor: Graham A. Hitman, Michael F. McDermott, David Curtis, A. Ramachandran, Chamukuttan Snehalatha, Barbara J. Boucher, B W Ogunkolade, Ebun Aganna

Publikováno v: Diabetologia. 40:971-975

Vitamin D has important immunomodulatory properties and prevents development of diabetes mellitus in an animal model of insulin-dependent diabetes (IDDM). We have studied the vitamin D receptor locus as a candidate for genetic susceptibility to IDDM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9d682a00e590b6c6ab009c072aef89
https://doi.org/10.1007/s001250050776

Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation

Autor: Marco Bugliani, Piero Marchetti, Marta Bagnati, Graham A. Hitman, Katie Hanna, Belinda Nedjai, Graham Ball, Tania A. Jones, Turner, B W Ogunkolade, Paul W. Caton, Muhammad M. Yaqoob, Julius Kieswich, Catriona Marshall, C Tucci

Publikováno v: Cell Death & Disease
Bagnati, M, Ogunkolade, B W, Marshal, C, Tucci, C, Hanna, K, Jones, T A, Bugliani, M, Nedjai, B, Caton, P W, Kieswich, J, Yaqoob, M M, Ball, G R, Marchetti, P, Hitman, G A & Turner, M D 2016, ' Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation ', Cell Death and Disease . https://doi.org/10.1038/cddis.2016.203

Type 2 diabetes is a chronic metabolic disorder, where failure to maintain normal glucose homoeostasis is associated with, and exacerbated by, obesity and the concomitant-elevated free fatty acid concentrations typically found in these patients. Hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74448eb4775284b4af0ac4d461b7ec77
https://doi.org/10.1038/cddis.2016.203

Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians

Autor: B W Ogunkolade, Graham A. Hitman, Barbara J. Boucher, N. Mannan, C. N. Hales, Michael F. McDermott, Ebun Aganna

Publikováno v: Diabetes. 47:688-690

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0d86dc57c89a5439ad93f7d78b4b66
https://doi.org/10.2337/diabetes.47.4.688

Expression of 25-hydroxyvitamin D-1-alpha-hydroxylase mRNA in individuals with colorectal cancer

Autor: Stephen A. Bustin, Paul J. Jenkins, Graham A. Hitman, Sina Dorudi, Barbara J. Boucher, Peter D. Fairclough, B W Ogunkolade

Publikováno v: Lancet (London, England). 359(9320)

Vitamin D prevents proliferation, promotes differentiation, and induces apoptosis of colon cells, and reduced intake or insufficiency of the vitamin in the body are associated with increased risk of colorectal cancer. Results of previous studies have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9201353052dc9c50939bfd61b0a1dd
https://pubmed.ncbi.nlm.nih.gov/12044381