Výsledky vyhledávání - "B W, Griffin"

The expression of functionally-coupled B2 -bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists

Autor: B. W. Griffin, T. K. Wiernas, N. A. Sharif

Publikováno v: British Journal of Pharmacology. 121:649-656

1. Bradykinin (BK) and Lys-BK are peptides which are released at high nanomolar concentrations into the tear-film of ocular allergic patients. We hypothesized that these peptides may activate specific receptors on the ocular surface, especially the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05fe1d04798654e5ed290e75583fc233
https://doi.org/10.1038/sj.bjp.0701168

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AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor

Autor: B W, Griffin, P, Klimko, J Y, Crider, N A, Sharif

Publikováno v: The Journal of pharmacology and experimental therapeutics. 290(3)

A novel analog of prostaglandin F(2alpha) [AL-8810; (5Z, 13E)-(9S, 11S,15R)-9,15-dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19, 20-pentanor-5,13-prostadienoic acid] has been discovered with uniquely low efficacy (E(max)) at the endogenous prostaglan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c2159b643a857707acc689d31cd36f9
https://pubmed.ncbi.nlm.nih.gov/10454504

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Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: pharmacological characterization using agonists and antagonists

Autor: J Y, Crider, B W, Griffin, N A, Sharif

Publikováno v: British journal of pharmacology. 127(1)

Various prostaglandin agonists representing various classes of receptor subtypes were evaluated for their ability to stimulate adenylyl cyclase via the endogenous DP receptor in embryonic bovine tracheal (EBTr) cells. Two antagonists were used to blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd361bbbda5e45464988fb79e622e7be
https://pubmed.ncbi.nlm.nih.gov/10369474

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Human corneal epithelial cell functional responses to inflammatory agents and their antagonists

Autor: N A, Sharif, T K, Wiernas, W E, Howe, B W, Griffin, E A, Offord, A M, Pfeifer

Publikováno v: Investigative ophthalmologyvisual science. 39(13)

To investigate the epithelial nature of primary and SV40 virus-immortalized human corneal epithelial (CEPI) cells and to study a variety of functional responses to some key inflammatory agents (bradykinin [BK], histamine, and platelet-activating fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6517340272122c1dd6104af0495387fa
https://pubmed.ncbi.nlm.nih.gov/9856766

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Pharmacology of [3H]prostaglandin E1/[3H]prostaglandin E2 and [3H]prostaglandin F2alpha binding to EP3 and FP prostaglandin receptor binding sites in bovine corpus luteum: characterization and correlation with functional data

Autor: N A, Sharif, S X, Xu, G W, Williams, J Y, Crider, B W, Griffin, T L, Davis

Publikováno v: The Journal of pharmacology and experimental therapeutics. 286(2)

Specific binding of [3H]prostaglandin (PG) E1, [3H]PGE2 and [3H]PGF2alpha to washed total particulate homogenates of bovine corpus luteum comprised 60 to 82% of total binding. Scatchard analysis of competition data revealed the presence of an apparen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::edb6e510350db3c41dde41fbbb579326
https://pubmed.ncbi.nlm.nih.gov/9694973

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Pharmacological characterization of an FP prostaglandin receptor on rat vascular smooth muscle cells (A7r5) coupled to phosphoinositide turnover and intracellular calcium mobilization

Autor: B W, Griffin, P E, Magnino, I H, Pang, N A, Sharif

Publikováno v: The Journal of pharmacology and experimental therapeutics. 286(1)

An FP prostaglandin (PG) receptor on the A7r5 rat aorta smooth muscle cell line has been characterized by assays of phosphoinositide (PI) turnover and intracellular calcium mobilization stimulated by structurally diverse PGs. In the PI turnover assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf9a57855a5a50c02d60130a06a9cfcc
https://pubmed.ncbi.nlm.nih.gov/9655886

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Effects of bradykinin on signal transduction, cell proliferation, and cytokine, prostaglandin E2 and collagenase-1 release from human corneal epithelial cells

Autor: T K, Wiernas, T L, Davis, B W, Griffin, N A, Sharif

Publikováno v: British journal of pharmacology. 123(6)

1. We recently demonstrated the presence of phospholipase C-coupled bradykinin (BK) B2-receptors in human primary and SV40 virus-immortalized corneal epithelial (CEPI) cells. 2. The aims of the present studies were to demonstrate the specific binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1dcaae122769ef8f9f5d167d1226035a
https://pubmed.ncbi.nlm.nih.gov/9559896

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Topical formulations of novel angiostatic steroids inhibit rabbit corneal neovascularization

Autor: D, BenEzra, B W, Griffin, G, Maftzir, N A, Sharif, A F, Clark

Publikováno v: Investigative ophthalmologyvisual science. 38(10)

To evaluate the antiangiogenic potential of topical ophthalmic formulations of the novel angiostatic steroids AL-3789 and AL-4940, using a rabbit model of corneal neovascularization.Neovascularization was induced in the rabbit cornea by surgical impl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b942ff6842007fe951998a366b7772b7
https://pubmed.ncbi.nlm.nih.gov/9331259

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The expression of functionally-coupled B2-bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists

Autor: T K, Wiernas, B W, Griffin, N A, Sharif

Publikováno v: British journal of pharmacology. 121(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69455548a93892b0d3432c1fe0488c07
https://pubmed.ncbi.nlm.nih.gov/9208130

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