PRECLINICAL EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY

Autor: H. Pavel, N. Ajeawung, R. Faure, D. Poirier, D. Kamnasaran, H. Joshi, X. Lun, F. Zemp, B. Sun, O. Stechishin, A. Luchman, J. J. Kelly, S. Weiss, M. G. Hamilton, G. Cairncross, D. L. Senger, J. Bell, G. McFadden, P. A. Forsyth, S. Y. Tzeng, H. Guerrero-Cazares, E. E. Martinez, N. P. Young, J. C. Sunshine, A. Quinones-Hinojosa, J. J. Green, L. Lei, R. D'Amico, J. Sisti, R. Leung, A. M. Sonabend, P. Guarnieri, S. S. Rosenfeld, J. N. Bruce, P. Canoll, V. R. Baichwal, L. Reeves, B. L. Chad, K. H. Zavitz, A. P. Beelen, G. G. Mather, R. O. Carlson, C. Manton, J. Chandra, S. T. Keir, D. A. Reardon, J. R. Saling, L. S. Gray, D. D. Bigner, H. S. Friedman, J. Zhang, J. Brun, H. Ogbomo, Z. Wang, D. J. Stojdl, L.-Y. Kong, M. A. Hatiboglu, J. Wei, Y. Wang, K. A. McEnery, G. N. Fuller, W. Qiao, M. A. Davies, W. Priebe, A. B. Heimberger, B. Amendolara, O. Gil, S. Ivkovic, J. Bruce, S. Rosenfeld, S. Finniss, B. Perlstein, C. Miller, H. Okhrimenko, G. Kazimirsky, S. Cazacu, N. Lemke, S. Brodie, S. A. Rempel, M. Rosenblum, T. Mikkelsen, S. Margel, C. Brodie, H. Guvenc, H. Demir, S. Gupta, S. Mazumder, A. Ray-Chaundhury, T. Li, C. Li, I. Nakano, R. Rahman, C. Rahman, S. Smith, D. Macarthur, F. Rose, K. Shakesheff, R. G. Grundy, A. J. Brenner, B. Goins, A. Bao, J. Miller, A. Trevino, R. Zuniga, W. T. Phillips, A. G. Gilg, K. G. Bowers, B. P. Toole, B. L. Maria, G. K. Leung, S. Sun, S. T. Wong, X. Q. Zhang, J. K. Pu, W. M. Lui, A. M. Marino, I. M. Hussaini, S. Amos, K. Simpson, G. T. Redpath, C. Lyons, C. Dipierro, G. A. Grant, C. Wilson, S. Salami, P. Macaroni, S. Li, J.-Y. Park, D. Needham, D. Bigner, M. Dewhirst, J. Ohlfest, J. Gallardo, S. Argawal, R. Mittapalli, R. Donelson, W. F. Elmquist, T. Nicolaides, S. Hariono, K. Barkovich, R. Hashizume, D. Rowitch, W. Weiss, D. Sheer, S. Baker, B. Paugh, T. Waldman, H. Li, C. Jones, T. Forshew, D. James, H. Caroline, R. Patrick, L. Katrin, F. Karl, T. Ghazaleh, W. Michael, V. Albrecht, J. Thorsteinsdottir, E. Wagner, J.-C. Tonn, M. Ogris, C. Schichor, G. Charest, B. Paquette, L. Sanche, D. Mathieu, D. Fortin, X. Qi, F. Cuttitta, Z. Chu, J. Celerier, J. Pakradouni, O. Rixe, A. Gragg, S. Muller, A. Banerjee, J. Phillips, M. Prados, D. Haas-Kogan, N. Gupta, L. Florence, V. G. Gwendoline, M. Veronique, K. Robert, S. Agarwal, R. K. Mittapalli, L. Cen, B. L. Carlson, J. N. Sarkaria, S. Sengupta, S. D. Weeraratne, S. Rallapalli, V. Amani, J. Pierre-Francois, N. Teider, A. Rotenberg, J. Cook, S. L. Pomeroy, F. Jenses, Y.-J. Cho, M. Hjouj, D. Last, D. Guez, D. Daniels, J. Lavee, B. Rubinsky, Y. Mardor, L. P. Serwer, C. O. Noble, K. Michaud, D. C. Drummond, T. Ozawa, Y. Zhou, J. D. Marks, K. Bankiewicz, J. W. Park, W. Wang, H. Cho, M. Weintraub, N. Jhaveri, S. Torres, N. Petasis, A. H. Schonthal, S. G. Louie, F. M. Hofman, T. C. Chen, Z. Grada, M. Hegde, D. R. Schaffer, A. Ghazi, T. Byrd, G. Dotti, W. Wels, H. E. Heslop, S. Gottschalk, M. Baker, N. Ahmed, K. J. Hamblett, C. J. Kozlosky, H. Liu, S. Siu, T. Arora, M. W. Retter, K. Matsuda, J. S. Hill, W. C. Fanslow, R. J. Diaz, A. Etame, O. Meaghan, T. Mainprize, C. Smith, K. Hynynen, J. Rutka, J. Pradarelli, J. Y. Yoo, A. Kaka, C. Alvarez-Breckenridge, Q. Pan, E. A. Chiocca, T. Teknos, B. Kaur, S. Y. Lee, B. Slagle-Webb, J. M. Sheehan, J. R. Connor, J. Cote, M. Lepage, F. Gobeil, A. Kleijn, R. Balvers, J. Kloezeman, C. Dirven, M. Lamfers, S. Leenstra, W. See, I.-L. Tan, R. Pieper, H. Jiang, E. White, C. I. Rios-Vicil, W.-K. A. Yung, C. Gomez-Manzano, J. Fueyo, F. J. Zemp, B. A. McKenzie, S. Mueller, X. Yang, I. Smirnov, D. C. James, J. J. Phillips, M. S. Berger, D. H. Rowitch, D. H. Haas-Kogan, B. Kennedy, V. Gopalakrishnan, C. Das, P. Taylor, R. Kommagani, X. Su, D. Aguilera, A. Thomas, J. Wolff, E. Flores, M. Kadakia, R. Alkins, P. Broderson, R. Sodhi, S. A. Chung, K. L. McDonald, H. Shen, B. W. Day, B. W. Stringer, T. Johns, S. Decollogne, C. Teo, P. J. Hogg, P. J. Dilda, T. R. Patel, J. Zhou, J. M. Piepmeier, W. M. Saltzman, M. A. Vogelbaum, P. Manchanda, J. R. Ohlfest, G. J. Kitange, A. C. Mladek, M. A. Schroeder, J. L. Pokorny, C. Mody, P. Forsyth, T. Dasgupta, C. D. James, A. B. Madhankumar, B. S. Webb, A. Park, K. Harbaugh, J. Sheehan

Publikováno v: Neuro-Oncology. 13:iii107-iii120

The 16th Annual Scientific Meeting of the Society for Neuro-Oncology in Conjunction with the AANS/CNS Section on Tumors, Orange County, California, USA, 17-20 November 2011. In Neuro-Oncology, 2011, v. 13 n. Suppl. 3, p. iii111, abstract no. ET-18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f8a6622c0d2b902c6070a98ae20619
https://doi.org/10.1093/neuonc/nor158

ChemInform Abstract: Synthesis and Biological Evaluation of a Series of 1,1-Dichloro-2,2,3- triarylcyclopropanes as Pure Antiestrogens

Autor: G. K. Mousissian, Magarian Ra, J. T. Pento, B. W. Day, K. L. Meyer, P. T. Jain

Publikováno v: ChemInform. 22

A series of 1,1-dichloro-2,2,3-triarylcyclopropanes (DTACs) was synthesized and evaluated as pure antiestrogens. Addition of 4-methoxy- or 4-(benzyloxy)phenyl Grignard reagents to p-methoxy, p-benzyloxy, or unsubstituted deoxybenzoins, followed by de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3536ad3a338abc31ac04b6f115a108ed
https://doi.org/10.1002/chin.199139133

Synthesis and biological evaluation of a series of 1,1-dichloro-2,2,3-triarylcyclopropanes as pure antiestrogens

Autor: K. L. Meyer, G. K. Mousissian, Magarian Ra, J. T. Pento, P. T. Jain, B. W. Day

Publikováno v: Journal of Medicinal Chemistry. 34:842-851

A series of 1,1-dichloro-2,2,3-triarylcyclopropanes (DTACs) was synthesized and evaluated as pure antiestrogens. Addition of 4-methoxy- or 4-(benzyloxy)phenyl Grignard reagents to p-methoxy, p-benzyloxy, or unsubstituted deoxybenzoins, followed by de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdef0a062002acae0cad69a0c892a90
https://doi.org/10.1021/jm00106a052

Z-1,1-Dichloro-2,3-diphenylcyclopropanes block human prostate carcinoma cell proliferation, inhibit prostate-specific antigen expression, and initiate apoptosis

Autor: R, Balachandran, S G, Grant, M J, Welsh, B W, Day

Publikováno v: The Prostate. 45(4)

Z-1,1-Dichloro-2,3-diphenylcyclopropane (A(II)) has long been known to be active against models of breast carcinoma. Microtubule perturbation and interaction at type II estrogen binding sites mediate its actions.Since these targets are potentially us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ea991ce358e92524aee72a4b59e0aa9
https://pubmed.ncbi.nlm.nih.gov/11102952

Cellular targets of the anti-breast cancer agent Z-1,1-dichloro-2,3-diphenylcyclopropane: type II estrogen binding sites and tubulin

Autor: E, ter Haar, E, Hamel, R, Balachandran, B W, Day

Publikováno v: Anticancer research. 17(3C)

Z-1,1-dichloro-2,3-diphenylcyclopropane (a.k.a. Analog II, AII) is a known anti-breast cancer agent with apparent antiestrogenic effects and remarkably low toxicity in rodents. We have recently shown that AII and its major metabolite Z-alpha-chloroch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89ca137a44e00598746094f49dbfdd79
https://pubmed.ncbi.nlm.nih.gov/9216636