Výsledky vyhledávání - "B Van den Eynde"

Is There a Clinical Future for IDO1 Inhibitors After the Failure of Epacadostat in Melanoma?

Autor: N van Baren, B Van den Eynde, Baurain J-F.

Publikováno v: Annual review of cancer biology, Vol. 4, no. 1, p. 241-256 (2020)

Indoleamine-2,3 dioxygenase 1 (IDO1) contributes to tumor immunosuppression by enzymatically degrading tryptophan, which is required for T cell activity, and producing kynurenine. Small-molecule inhibitors, such as epacadostat, have been developed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8541164434a5f17db7c11d6b8b0d01e7
https://doi.org/10.1146/annurev-cancerbio-030419-033635

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Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy

Tumoural-CD8+T cells exhibit exhausted or dysfunctional states. Contrary to immunotherapy-responsive exhausted-CD8+T cells, the clinical features of dysfunctional-CD8+T cells are disputed. Hence, we conducted large-scale multi-omics and multi-dimensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20e12bf5540ffc785b26709ed3420e9b
https://doi.org/10.1101/2021.11.22.468617

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The role of asunercept as a selective CD95L inhibitor in cutaneous melanoma: Rationale and results from an enhanced TiRP model

Autor: N. Kneisel, C. Gieffers, B Van den Eynde, J. Zhu, D. Richards, Andriy Krendyukov, C. Merz

Background CD95/CD95L signalling plays an important role in cancer cells resistant to CD95-mediated apoptosis and CD95L inhibition can overcome this mechanism. Several mechanisms related to apoptosis induction or dysfunction of effector T-cells via C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e72b1a2a2f1cd02ca1e8998474184e
https://ora.ox.ac.uk/objects/uuid:99a872a5-16de-42a4-be85-4b7000f9a09f

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Immunosuppression mediated by enzymes that degrade tryptophan

Autor: B. Van den Eynde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25d44980b9fc7687c64842c5bfa6e16
https://doi.org/10.1016/j.toxlet.2018.06.1098

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25P Improving efficacy and reducing toxicity of anti-PD-L1 treatment: T-cells as delivery vehicles for anti-PD-L1 blocking nanobodies

Autor: Jingjing Zhu, P-F. Petit, B Van den Eynde

Publikováno v: Annals of Oncology. 31:S1425

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ca6baa7cc44b5b41c8220c58f8dd18d
https://doi.org/10.1016/j.annonc.2020.10.511

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The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade

Publikováno v: Annals of Oncology
Annals of Oncology, 2017, 28 (8), pp.1934-1941. ⟨10.1093/annonc/mdx210⟩
Annals of Oncology, Oxford University Press (OUP), 2017, 28 (8), pp.1934-1941. ⟨10.1093/annonc/mdx210⟩
Annals of Oncology, Elsevier, 2017, 28 (8), pp.1934-1941. ⟨10.1093/annonc/mdx210⟩

Background Never-smokers and never-drinkers patients (NSND) suffering from oral squamous cell carcinoma (OSCC) are epidemiologically different from smokers drinkers (SD). We therefore hypothesized that they harbored distinct targetable molecular alte

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https://inria.hal.science/hal-01560943

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Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes

Autor: R Golnik, Wolfgang Uckert, Andrea Lehmann, Michele Mishto, Petra Henklein, Frédéric Ebstein, Beatrice Schuler-Thurner, B Van den Eynde, N Albrecht-Koepke, Sabrina Urban, Dirk Schadendorf, Peter-M. Kloetzel, Agathe Niewienda, Kathrin Textoris-Taube, Felix K.M. Lorenz, Christin Keller, Katharina Janek, Nathalie Vigneron

Publikováno v: Scientific Reports, Vol. 6, no.24032, p. / (6 avril 2016)
Scientific Reports

Proteasome-catalyzed peptide splicing represents an additional catalytic activity of proteasomes contributing to the pool of MHC-class I-presented epitopes. We here biochemically and functionally characterized a new melanoma gp100 derived spliced epi

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Rheumatoid arthritis synovial fibroblasts produce a soluble form of the interleukin-7 receptor in response to pro-inflammatory cytokines

Autor: Valérie Badot, Bernard Lauwerys, Patrick Durez, A. Nzeusseu-Toukap, B Van den Eynde, Frédéric Houssiau

Publikováno v: Journal of Cellular and Molecular Medicine, Vol. 15, no. 11, p. 2335-2342 (2011)
Journal of Cellular and Molecular Medicine

We previously demonstrated that baseline synovial overexpression of the interleukin-7 receptor α-chain (IL-7R) is associated with poor response to tumour necrosis factor (TNF) blockade in rheumatoid arthritis (RA). We found that IL-7R gene expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491c019eb11589924e33fc4ea3a13223
https://doi.org/10.1111/j.1582-4934.2010.01228.x

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Rituximab treatment induces the expression of genes involved in healing processes in the rheumatoid arthritis synovium

Autor: Frédéric Houssiau, Christine Galant, Ivan Théate, Patrick Durez, B Van den Eynde, Rik Lories, Ilse Gutierrez-Roelens, A. Nzeusseu-Toukap, Bernard Lauwerys

Publikováno v: Arthritis & Rheumatism. 63:1246-1254

Rituximab displays therapeutic benefits in the treatment of patients with rheumatoid arthritis (RA) resistant to tumor necrosis factor (TNF) blockade. However, the precise role of B cells in the pathogenesis of RA is still unknown. We undertook this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a386fbdbdc7e293c382a5113cd217996
https://doi.org/10.1002/art.30292

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Development and Tracking in Fitness Components: Leuven Longitudinal Study on Lifestyle, Fitness and Health

Autor: Roland Renson, Robert M. Malina, A. L. Claessens, M.A. van 't Hof, M. Ostyn, J. Simons, B. van den Eynde, J. Lefevre, Bart Vanreusel, Gaston Beunen

Publikováno v: Europe PubMed Central
International Journal of Sports Medicine, 18, 3, pp. s171-s178
International Journal of Sports Medicine, 18, s171-s178
International Journal of Sports Medicine, 18, pp. s171-s178

In the Leuven Growth Study of Belgian Boys the growth and physical performance of Belgian boys followed longitudinally between 12 and 19 years were studied. Subsequently, a subsample (n = 240) of Flemish-speaking males were reexamined at 30 and 35 ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bdc42bfad7132a6305c3a5e6e29188
https://doi.org/10.1055/s-2007-972710

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