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A15 GENETIC OR DIET-ASSOCIATED DEFECTS IN MUCUS FACILITATE ULCERATIVE COLITIS PATHOBIONT-DRIVEN COLITIS

Autor: H Yang, X Han, C Ma, H Yu, B Vallance

Publikováno v: Journal of the Canadian Association of Gastroenterology. 6:8-9

Background The Inflammatory Bowel Diseases (IBD), Crohn’s Disease (CD) and ulcerative colitis (UC) affect > 270,000 Canadians and are increasing in incidence. Ileal CD has been linked to the overgrowth of mucosal adherent E. coli. Recent studies ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::658f8f215191f04d0adc28abef31d036
https://doi.org/10.1093/jcag/gwac036.015

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A40 GUT MICROBIOTA PROMOTES NUTRIENT AVAILABLITY AND PATHOGENESIS OF AN ATTACHING/ EFFACING BACTERIAL PATHOGEN

Autor: Q Liang, J Allaire, L Celiberto, H Yu, B Vallance

Publikováno v: Journal of the Canadian Association of Gastroenterology. 6:22-23

Background Our gut microbiota plays an important role in protecting the gastrointestinal (GI) tract from invading enteric pathogens. Much of this colonization resistance is mediated by limiting nutrient availability, however, enteric pathogens have e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::090f7220c33f1cb75dbbbc9458d5bbc3
https://doi.org/10.1093/jcag/gwac036.040

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Akademický článek

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Akademický článek

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K zobrazení výsledku je třeba se přihlásit.

A48 LYOPHILIZED FECAL MICROBIOTA TRANSPLANT (FMT) DELAYS THE ONSET OF SPONTANEOUS COLITIS IN MUC2-/- MICE

Autor: J J Chan, C Chan, H P Sham, B Vallance

Publikováno v: Journal of the Canadian Association of Gastroenterology. 6:27-27

Background Fecal microbiota transplant (FMT) is the transfer of fecal microbes from a healthy donor to a recipient to normalize gut microbiota. FMT therapy has been effectively used to prevent recurrent Clostridium difficile infections. While there a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48c21ab95dc965daf2b68ed0e0527093
https://doi.org/10.1093/jcag/gwac036.048

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A40 IDENTIFYING NOVEL ROLES FOR TLR2 SIGNALING IN THE INTESTINAL EPITHELIUM USING ORGANOIDS

Autor: Y Chen, J M Allaire, X Han, H Yang, S M Crowley, B Vallance

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:47-48

Background Inflammatory bowel disease (IBD) is thought to result from an imbalance between protective and damaging immune responses to the resident microbiota and other luminal antigens. Increasing evidence suggests that toll-like-receptor (TLR)-medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1e42994f0c18646eb36d83f3b1cba0a
https://doi.org/10.1093/jcag/gwab049.039

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A2 MUCUS DEFICIENCY IMPACTS INTESTINAL EPITHELIAL CELL PROLIFERATION INDEPENDENT OF THE MICROBIOTA

Autor: X Han, K Tsai, J M Allaire, S M Crowley, A Lorentzian, C Maxwell, B Vallance

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:2-3

Background Intestinal homeostasis is highly dependent on the proliferation and differentiation of intestinal epithelial cells (IEC). IEC arise from intestinal stem cells (ISCs) that reside at the bottom of intestinal crypts. Following proliferation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eed6beb5f9d936a55d84a657b89d64a5
https://doi.org/10.1093/jcag/gwab049.001

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A9 SIALIC ACID METABOLISM PLAYS A KEY ROLE IN INTESTINAL FITNESS AND VIRULENCE OF AN ATTACHING/ EFFACING BACTERIAL PATHOGEN

Autor: Q Liang, J M Allaire, H Yu, S M Crowley, X Han, B Vallance

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:10-11

Background The gastrointestinal (GI) mucus barrier acts as an important interface between the host and luminal gut microbes, beyond its role in limiting direct contact between noxious luminal agents and the underlying intestinal epithelium. Mucus is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58bb4be2153c52d91a76b0a235dcd3f6
https://doi.org/10.1093/jcag/gwab049.008

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A228 A FERMENTABLE FIBRE FREE DIET ACCELERATES SPONTANEOUS COLITIS DEVELOPMENT AND ALTERS THE GUT MICROBIOME IN MUC2-/- MICE

Autor: G R Healey, A Schick, K Jacobson, B Vallance

Publikováno v: Journal of the Canadian Association of Gastroenterology. 5:119-120

Background A key feature of ulcerative colitis (UC) is a defective colonic mucus layer. As Muc2-/- mice lack intestinal mucus, they’re often used to model UC. In these mice, luminal bacteria translocate from the gut lumen, triggering spontaneous co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e61ea8c1d17e17640f388938f1e0c822
https://doi.org/10.1093/jcag/gwab049.227

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