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[MiRNA miR-375 as a Multifunctional Regulator of the Cardiovascular System]

Autor: N A, Matveeva, N M, Baulina, I S, Kiselev, B V, Titov, O O, Favorova

Publikováno v: Molekuliarnaia biologiia. 56(3)

MicroRNA (miRNA) miR-375 acts as a multifunctional regulator of the activity of many physiological and pathological cellular processes by interacting with a large number of target genes. MiR-375 is involved in the regulation of the differentiation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::940bc8be77cdd6067b1b5c66c3989acd
https://pubmed.ncbi.nlm.nih.gov/35621097

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The Myocardial Infarction Associated Variant in the MIR196A2 Gene and Presumable Signaling Pathways to Involve miR-196a2 in the Pathological Phenotype

Autor: German Osmak, B. V. Titov, N. A. Matveeva, O O Favorova

Publikováno v: Molecular Biology. 52:872-877

The heritable component of susceptibility to myocardial infraction (MI) remains unexplained, possibly due to the minor effects of genes, which are not obviously associated with the disease. These genes may be integrated in miRNA regulated networks as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f31c3d02fd8b6c55e5cd082d8abdd915
https://doi.org/10.1134/s0026893318060146

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Impact of 9p21.3 region and atherosclerosis-related genes' variants on long-term recurrent hard cardiac events after a myocardial infarction

Autor: V. V. Bashinskaya, German Osmak, N. A. Matveeva, Nino G. Kukava, O O Favorova, B. V. Titov, Mikhail Ya. Ruda, Tatiana S. Sukhinina, R. M. Shakhnovich

Publikováno v: Gene. 647:283-288

Atherosclerotic coronary artery disease (CAD) and myocardial infarction (MI) as its most severe clinical complication remain the leading causes of mortality in the majority of countries. Despite the progress in the treatment of MI, quite often the pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5e772ee755e5403389c53c61f41c57
https://doi.org/10.1016/j.gene.2018.01.036

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Towards Understanding the Genetic Nature of Vasovagal Syncope

Autor: N. A. Matveeva, Alexander Pevzner, B. V. Titov, Olga O. Favorova, Elizabeth Bazyleva

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 10316, p 10316 (2021)

Syncope, defined as a transient loss of consciousness caused by transient global cerebral hypoperfusion, affects 30–40% of humans during their lifetime. Vasovagal syncope (VVS) is the most common cause of syncope, the etiology of which is still unc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d298b4c196ecc2d78223576a8a47d0b4
https://doi.org/10.3390/ijms221910316

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Multilocus Analysis of Genetic Susceptibility to Myocardial Infarction in Russians: Replication Study

Autor: Nino G. Kukava, O O Favorova, B. V. Titov, N. A. Matveeva, M Ya Ruda, R. M. Shakhnovich, Alexander V. Favorov, German Osmak, Olga Kulakova

Publikováno v: Acta Naturae. 9:74-83

In search of genetic markers of myocardial infarction (MI) risk, which have prognostic significance for Russians, we performed a replication study of MI association with genetic variants of PCSK9 (rs562556), APOE (epsilon polymorphism, rs7412 and rs4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7502c6d958674cb1af30003070b3fb01
https://doi.org/10.32607/20758251-2017-9-4-74-83

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Genetic risk factors for myocardial infarction more clearly manifest for early age of first onset

Autor: Nino G. Kukava, Mikhail Ya. Ruda, R. M. Shakhnovich, German Osmak, Alexander V. Favorov, B. V. Titov, N. A. Matveeva, O O Favorova

Publikováno v: Molecular Biology Reports. 44:315-321

Epidemiological genetics established that heritability in determining the risk of myocardial infarction (MI) is substantially greater when MI occurs early in life. However, the genetic architecture of early-onset and late-onset MI was not compared. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311fc8b1fa30ba292895d7fc08cfb193
https://doi.org/10.1007/s11033-017-4112-5

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The combined effects of myocardial infarction risk factors: Simulation of the combined effects of gene variants, age, and smoking and an analysis of their interaction

Autor: Dmitrijs Lvovs, O O Favorova, Alexander V. Favorov, B. V. Titov, N. A. Matveeva, German Osmak

Publikováno v: Biophysics. 62:123-128

Regression analysis has been used to model the combined influence of adverse factors, namely, specific variants of the CRP (rs1130864), IFNG (rs2430561), TGFB1 (rs1982073), FGB (rs1800788), and PTGS1 (rs3842787) genes; age; and smoking on the risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71cdf9bc4dac2578dbbe36372ecdcb93
https://doi.org/10.1134/s0006350917010146

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Мультилокусный анализ ассоциации полиморфных вариантов генов системы воспаления с ишемическим инсультом у русских

Autor: M Yu Martynov, Olga O. Favorova, B. V. Titov, N. A. Matveeva

Publikováno v: Молекулярная биология. 50:674-684

Carriage frequencies of alleles and genotypes of polymorphic loci of inflammation genes (49A>G CTLA4, 41G>A and 87C>T PDE4D, −590C>T IL4, −308A>G TNF, 252G>A LTA, 874A>T IFNG, −509С>Т, 869T>C and 915G>C TGFB1) were determined in a sample of 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::001d3c71995b0cfb49f9e91d1bcdd8d1
https://doi.org/10.7868/s0026898416040145

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