Zobrazeno 1 - 10
of 18
pro vyhledávání: '"B V, Potter"'
Publikováno v:
The Journal of Immunology. 155:3353-3359
Ca2+ release from intracellular stores is one of the major events transducing extracellular signals into living cells. Recently, a metabolite of nicotinamide adenine dinucleotide+ (NAD+), termed "cyclic adenosine diphosphate-ribose" (cADPr), has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6b78949616e7809033b7a6718b44bb
https://doi.org/10.4049/jimmunol.155.7.3353
https://doi.org/10.4049/jimmunol.155.7.3353
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 7(22)
The adenophostins exhibit approximately 10-100 times higher receptor binding and Ca2+ mobilising potencies in comparison with the natural second messenger D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Despite many synthetic attempts to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26dddfff6eeb5d6ac29c416d7640fbee
https://pubmed.ncbi.nlm.nih.gov/11763462
https://pubmed.ncbi.nlm.nih.gov/11763462
Autor:
G, Horne, B V, Potter
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 7(1)
D-myo-Inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] is produced rapidly from the established second messenger D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P4] in stimulated cells. Despite extensive investigations, in particular concerning its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f61ad5e578522234fe1dba60e486fcd
https://pubmed.ncbi.nlm.nih.gov/11205029
https://pubmed.ncbi.nlm.nih.gov/11205029
Publikováno v:
Cancer research. 60(13)
The development of potent steroid sulfatase inhibitors is an important new therapeutic strategy for the treatment of postmenopausal women with breast cancer. A series of tricyclic coumarin sulfamates were synthesized, and their inhibitory properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32bd8fc22818a37bc548959ac78b8a5d
https://pubmed.ncbi.nlm.nih.gov/10910045
https://pubmed.ncbi.nlm.nih.gov/10910045
Publikováno v:
International journal of cancer. 85(4)
2-Methoxyoestrogens are emerging as a new class of drug that can inhibit tumour growth and angiogenesis. As sulphamoylation of oestrogens enhances their potency and bioavailability we have synthesized 2-methoxyoestrone-3-O-sulphamate (2-MeOEMATE) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::607f10825c1590ee56db70cf3fcc291e
https://pubmed.ncbi.nlm.nih.gov/10699934
https://pubmed.ncbi.nlm.nih.gov/10699934
Autor:
P, Whiteaker, A R, Davies, M J, Marks, I S, Blagbrough, B V, Potter, A J, Wolstenholme, A C, Collins, S, Wonnacott
Publikováno v:
The European journal of neuroscience. 11(8)
[3H]-Methyllycaconitine ([3H]-MLA) is a new radioligand with selectivity for alpha7-type neuronal nicotinic acetylcholine receptors (nAChRs). In our previous study [Davies, A.R.L., Hardick, D.J., Blagbrough, I.S., Potter, B.V.L., Wolstenholme, A.J.Wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88b03078332aa2de46ec172b51867fd8
https://pubmed.ncbi.nlm.nih.gov/10457165
https://pubmed.ncbi.nlm.nih.gov/10457165
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(3)
The synthesis of 1-O-[(3S,4R)-3-hydroxytetrahydrofuran-4-yl]-alpha-D-glucopyranosid e 3,4,3'-trisphosphate (7), a novel Ca2+ mobilising agonist at the Ins(1,4,5)P3 receptor, designed by excision of two motifs of adenophostin A is reported, defining a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::392b5f6aacbe938a392baa6ecbe31ec6
https://pubmed.ncbi.nlm.nih.gov/10091701
https://pubmed.ncbi.nlm.nih.gov/10091701
Publikováno v:
Advances in experimental medicine and biology. 419
Intracellular Ca(2+)-signals belong to the major events transducing extracellular signals into living cells. The discovery of (i) a caffeine-sensitive intracellular Ca(2+)-pool in Jurkat T-lymphocytes [1] and (ii) cyclic adenosine diphosphoribose (cA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4fde8028818fe20a36d11bca9bee5d92
https://pubmed.ncbi.nlm.nih.gov/9193685
https://pubmed.ncbi.nlm.nih.gov/9193685
Publikováno v:
Cancer research. 56(21)
Steroid sulfatase regulates the formation of estrone from estrone sulfate (E1S) and dehydroepiandrosterone (DHA) from DHA sulfate. DHA can be converted to androstenediol, a steroid with potent estrogenic properties, and inhibition of steroid sulfatas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e84ae979f8e291f7cb715df00834431d
https://pubmed.ncbi.nlm.nih.gov/8895749
https://pubmed.ncbi.nlm.nih.gov/8895749
Publikováno v:
Molecular pharmacology. 50(5)
The naturally occurring tetrakisphosphate myo-inositol-1,3,4, 6-tetrakisphosphate [Ins(1,3,4,6)P4] was able to release Ca2+ from the intracellular stores of permeabilized rabbit platelets but was 40-fold less potent than D-myo-inositol-1,4,5-trisphos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51dc28e9244a708da595c0b0bf135de0
https://pubmed.ncbi.nlm.nih.gov/8913354
https://pubmed.ncbi.nlm.nih.gov/8913354