Zobrazeno 1 - 10
of 118
pro vyhledávání: '"B T Rouse"'
Autor:
I. A. Davis, B. T. Rouse
Publikováno v:
Laboratory Animals. 34:111-114
The transmigration of lymphocytes across vascular endothelium is a critical step for the localization of lymphocytes to lymph nodes in both naïve and immune reactive states. Mice deficient in lymphotoxin-alpha (LT- α)lack peripheral and gut associa
Publikováno v:
The Journal of Immunology. 158:1383-1391
Corneal infection with herpes simplex virus-1 in immunocompetent mice induces an immunopathologic response termed herpetic stromal keratitis (HSK). The earliest sign of disease is neutrophil infiltration, which lasts for 48 to 72 h and then disappear
Publikováno v:
The Journal of Immunology. 156:1110-1116
In this report we investigated whether induction of IL-12 occurs in response to herpes simplex virus (HSV) infection of the mouse eye, which may serve to regulate the nature of the subsequent immune response. The data show early induction and continu
Publikováno v:
The Journal of Immunology. 155:3964-3971
Herpetic stromal keratitis (HSK) has an immune-mediated pathogenesis that involves T cells that have a type 1 cytokine profile. IFN-gamma is suspected to be the type 1 cytokine involved in ocular pathology, and to test this notion more directly the p
Autor:
T A Banks, B T Rouse, M K Kerley, P J Blair, V L Godfrey, N A Kuklin, D M Bouley, J Thomas, S Kanangat, M L Mucenski
Publikováno v:
The Journal of Immunology. 155:1685-1693
Targeted mutagenesis in embryonic stem cells was used to generate mice deficient in lymphotoxin-alpha (LT-alpha). Mice lacking LT-alpha -/- (LT-alpha -/- mice) exhibit a phenotype dominated by defects in secondary lymphoid organ development. LT-alpha
Publikováno v:
The Journal of Immunology. 155:259-265
Plasmid DNA encoding proteins represent a convenient novel approach to vaccination. We have investigated this "genetic immunization" approach as a means to protect against herpes simplex virus (HSV) infection using a mouse zosteriform model that mimi
Publikováno v:
The Journal of Immunology. 154:4822-4829
Corneal infection with herpes simplex virus in mice induces an inflammatory response in the stroma (herpetic stromal keratitis (HSK)) that appears to represent an immunopathologic reaction in which T cells of the CD4+ subset act as the essential part
Publikováno v:
The Journal of Immunology. 153:3764-3774
Mice hemizygous for the X-linked mutation, scurfy (sf), exhibit a fatal lymphoreticular disease that is mediated by T lymphocytes. To evaluate the respective roles of CD4 or CD8 single positive T cells in scurfy disease, neonates were treated with mA
Publikováno v:
Methods in molecular medicine. 10
Protective immunity against a eajority of viral infections is mediated by a combination of both humoral and cell-mediated immune responses. However, in the case of herpesvirus infections, where viral spread is largely cell-to-cell, cell-mediated immu
Publikováno v:
The Journal of Immunology. 149:1599-1604
Intravenous administration of APC such as splenocytes loaded with a soluble protein Ag has been shown to prime for an Ag-specific CTL response. It is thought that the APC directly presents loaded Ag in a MHC-restricted manner. However, it is demonstr