Zobrazeno 1 - 10
of 2 156
pro vyhledávání: '"B T, Hyman"'
Autor:
V. Beglopoulos, J. Tulloch, A. D. Roe, S. Daumas, L. Ferrington, R. Watson, Z. Fan, B. T. Hyman, P. A. T. Kelly, F. Bard, R. G. M. Morris
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Identifying early signs of Alzheimer’s disease is important when it comes to diagnosis and treatment. Here, the authors identify subtle memory retrieval deficits and associated brain glucose uptake impairments in very young mouse models of Alzheime
Externí odkaz:
https://doaj.org/article/bc84409521634c90b7caf898191d133d
Autor:
Marie-Laure Charpignon, Kyle Evans, Steven Rodriguez, Mark W. Albers, B. Zhang, Yi-Han Sheu, Deborah Blacker, Bella Vakulenko-Lagun, Ioanna Tzoulaki, Rebecca A. Betensky, Saumya Das, R. E. Welsch, Sarah A. Boswell, B. T. Hyman, A. Sololov, S. N. Finkelstein, C. Magdomo, Bowen Su, Lefkos T. Middleton, M. Somai
Metformin, an antidiabetic drug, triggers anti-aging cellular responses. Aging is the principal risk factor for dementia, but previous observational studies of the diabetes drugs metformin vs. sulfonylureas have been mixed. We tested the hypotheses t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acfec084548364c3449c4c724339daba
https://doi.org/10.1101/2021.08.10.21261747
https://doi.org/10.1101/2021.08.10.21261747
Autor:
Simon Dujardin, Dudley K. Strickland, Allison L. Arai, Molly Migliorini, Mashhood Wani, B. T. Hyman, Joanna M. Cooper, Aurélien Lathuilière, Selen C. Muratoglu
The identification of the apoE receptor, LRP1, as an endocytic receptor for tau raises several questions about LRP1s’ role in tauopathies. Is internalized tau, like other LRP1 ligands, delivered to lysosomes for degradation? Does LRP1 internalize p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dcf8436a7f69e8019c2890b7cfc4ff3
https://doi.org/10.1101/2020.11.17.386581
https://doi.org/10.1101/2020.11.17.386581
Autor:
Robert Morris, Yikai Kuo, Bianca A. Trombetta, Robert R. Kitchen, Johannes Kreuzer, Vlad Petyuk, Julie A. Schneider, Becky C. Carlyle, B. T. Hyman, Angus C. Nairn, David A. Bennett, Savannah E. Kandigian, Saumya Das, Steven E. Arnold, Wilhelm Haas
Alzheimer's disease (AD) is a complex neurodegenerative disease defined by the presence of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles, and driven by dysproteostatis, inflammation, metabolic dysfunction, and oxidative injury, eventuall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c48d7602070bd785a07675c1099eb514
https://doi.org/10.1101/2020.07.31.230680
https://doi.org/10.1101/2020.07.31.230680
Autor:
Nienke Moret, Mark W. Albers, Artem Sokolov, Steven Rodriguez, George Zhou, B. T. Hyman, Petar Todorov, Peter K. Sorger, Nathan T. Johnson, Clemens B. Hug, Sarah A. Boswell, Kyle Evans
Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a large amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA) for another indication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f2eb35efdb612c915ea1f8f6803134
https://doi.org/10.1101/2020.05.15.098749
https://doi.org/10.1101/2020.05.15.098749
Autor:
B. T. Hyman, Sarah C. Hopp, Jeffrey Helgager, Julie A. Schneider, Jeffrey A. Golden, Mariko Taga, Rani A. Sarkis, Garth Rees Cosgrove, Maria Cimpean, Marta Olah, Naomi Habib, Khairalla A, Aviv Regev, Matthew P. Frosch, Christina J. Yung, Elizabeth M. Bradshaw, David A. Bennett, Danielle Dionne, Wassim Elyaman, Thomas G. Beach, Page B. Pennell, De Jager Pl, Menon
Recent studies of bulk microglia have provided insights into the role of this immune cell type in central nervous system development, homeostasis and dysfunction. Nonetheless, our understanding of the diversity of human microglial cell states remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f013f783eeeb89d0a495b855c7dd323
https://doi.org/10.1101/343780
https://doi.org/10.1101/343780
Autor:
Steven Rodriguez, Al-Lawati H, Elena Ratti, Benjamin R. Schrank, Eric G. Benz, Alefiya Dhilla Albers, Michael E. Talkowski, Matthew P. Frosch, Asli Sahin, Alexis C. Gomez, Isabel Costantino, B. T. Hyman, Mark W. Albers, Peter K. Sorger, Luxiang Cao, Fard D, Merit Cudkowicz
SUMMARYInnate immune signaling activation and DNA damage are pathological hallmarks of aging that may herald multiple adult-onset neurodegenerative diseases. Here, we report that both cell autonomous and non-autonomous neuronal death are triggered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc525c04ec1d54d938995721aec3f0a
https://doi.org/10.1101/248328
https://doi.org/10.1101/248328
Autor:
B. T. Hyman, M. Stampfer, Michael C. Irizarry, S.M. Greenberg, Anand Viswanathan, S. Campbell, S. Raj
Publikováno v:
Neurology. 72:268-272
Background: Amyloid-beta protein (Aβ) plays a key role in Alzheimer disease (AD) and is also implicated in cerebral small vessel disease. Serum total homocysteine (tHcy) is a risk factor for small vessel disease and cognitive impairment and correlat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e7ac352f4b8cc51ef68ba747930abe
https://doi.org/10.1212/01.wnl.0000339486.63862.db
https://doi.org/10.1212/01.wnl.0000339486.63862.db
Autor:
Sun, Yung‐Chen1,2 (AUTHOR), Hsieh, Tsung‐Lun1 (AUTHOR), Lin, Chia‐I1 (AUTHOR), Shao, Wan‐Yu3 (AUTHOR), Lin, Yu‐Hao1,2 (AUTHOR), Huang, Jie‐rong1,3,4 (AUTHOR) jierongh@nycu.edu.tw
Publikováno v:
Advanced Science. 11/6/2024, Vol. 11 Issue 41, p1-13. 13p.
Autor:
Wang, Yajie1 (AUTHOR), Yang, Yuting1 (AUTHOR), Cai, Ying1 (AUTHOR), Aobulikasimu, Ayikaimaier1 (AUTHOR), Wang, Yuexin1 (AUTHOR), Hu, Chuanwei1 (AUTHOR), Miao, Zhikang1 (AUTHOR), Shao, Yue1 (AUTHOR), Zhao, Mengna1 (AUTHOR), Hu, Yue1 (AUTHOR), Xu, Chang1 (AUTHOR), Chen, Xinjun2 (AUTHOR), Li, Zhiqiang2 (AUTHOR), Chen, Jincao2 (AUTHOR), Wang, Lianrong1,3 (AUTHOR) lianrong2008@gmail.com, Chen, Shi1,4 (AUTHOR) shichen@whu.edu.cn
Publikováno v:
Advanced Science. 11/6/2024, Vol. 11 Issue 41, p1-18. 18p.