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Publikováno v:
Anti-Cancer Drugs. 3:91-94
Suramin exhibited morphine-like analgesic activity in mice. It antagonized both thermal (hot-plate) and acetic acid-evoked writhing responses with ED50 values 1/100 and 1/68, respectively, that of morphine. The suramin- and morphine-induced hot-plate
Publikováno v:
Research communications in chemical pathology and pharmacology. 67(1)
LY195448(R) (a phenethanolamine derivative that has demonstrated cytotoxic activity against cell cultures in vitro but that exhibited a hypotensive side effect during phase I trials), its p-hydroxy and acid metabolites, and a noncytotoxic S-stereoiso
Publikováno v:
Anti-Cancer Drugs. 2:267-268
In the investigation of effects of platinum-containing compounds on dopamine (DA)-activated adenylate cyclase system, tetraplatin and cisplatin were found to suppress the increase of enzyme activity by various activators. However, tetraplatin was a m
Publikováno v:
European Journal of Pharmacology. 183:238
Publikováno v:
Journal of Neural Transmission. 48:289-295
Following a single dose of phencyclidine (PCP) striatal tyrosine hydroxylase (TH) activity was decreased 42% 15 min after PCP administration, but returned toward baseline levels by 45 min post-drug. Twenty-four hours after the 30th dose of PCP, TH ac
Publikováno v:
Acta Psychiatrica Scandinavica. 67:307-314
The effect of relaxation training, utilizing EMG biofeedback, on platelet monoamine oxidase (MAO) activity was examined in patients with a history of chronic anxiety. Anxiety scores and MAO activity were significantly lowered after 4 weeks of therapy
Publikováno v:
Brain Research Bulletin. 6:473-478
The attempt of this study was to investigate the direct effects of increasing doses of morphine on the neuronal activity of the periaqueductal gray in morphine-naive and morphine-dependent rats. The microiontophoresis technique was used for this purp
Publikováno v:
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 73:205-209
1. The response of caudate nucleus neurons to morphine was found to be dose-dependent and could be divided into two classes: neurons which responded monophasically either by increase or decrease in their firing rate, and neurons whose response can be
Publikováno v:
Acta Psychiatrica Scandinavica. 65:142-147
Plasma catecholamines and heart rate were determined in drug-free groups of anxious patients and normal controls before and 20 min after intramuscular injection of 0.01 mg/kg of 1/1000 diluted epinephrine. Levels of anxiety after the injection were d