Zobrazeno 1 - 10
of 185
pro vyhledávání: '"B Seydel"'
Autor:
Isobel S. Walker, Saber Dini, Elizabeth H. Aitken, Timon Damelang, Wina Hasang, Agersew Alemu, Anja T. R. Jensen, Janavi S. Rambhatla, D. Herbert Opi, Michael F. Duffy, Eizo Takashima, Visopo Harawa, Takafumi Tsuboi, Julie A. Simpson, Wilson Mandala, Terrie E. Taylor, Karl B. Seydel, Amy W. Chung, Stephen J. Rogerson
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration in the vasculature. PfEMP1 is a major target of protective antibodies,
Externí odkaz:
https://doaj.org/article/207469fd56754378a72987ad51f59013
Autor:
Alick Sixpence, Maclean Vokhiwa, Wangisani Kumalakwaanthu, Nicola J. Pitchford, Karl B. Seydel, Laurence S. Magder, Miriam K. Laufer, Don P. Mathanga, Lauren M. Cohee
Publikováno v:
EClinicalMedicine, Vol 76, Iss , Pp 102832- (2024)
Summary: Background: School-age children in sub-Saharan Africa suffer an underappreciated burden of malaria which threatens their health and education. To address this problem, we compared the efficacy of two school-based chemoprevention approaches:
Externí odkaz:
https://doaj.org/article/b3614624e5764f9889b00f2da1d26206
Autor:
Jimmy Vareta, Natalie A. Horstman, Matthew Adams, Karl B. Seydel, Robert S. McCann, Lauren M. Cohee, Miriam K. Laufer, Shannon Takala-Harrison
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-11 (2024)
Abstract Background Understanding the dynamics of gametocyte production in polyclonal Plasmodium falciparum infections requires a genotyping method that detects distinct gametocyte clones and estimates their relative frequencies. Here, a marker was i
Externí odkaz:
https://doaj.org/article/5783ff4d775547c6953036af76f2d2dc
Autor:
Ronke Olowojesiku, Meredith G. Sherman, Amina M. Mukadam, Rami Imam, Kennedy M. Chastang, Karl B. Seydel, Alice M. Liomba, John R. Barber, Nicole F. O’Brien, Douglas G. Postels
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-8 (2024)
Abstract Background In children with cerebral malaria (CM) admission blood lactate has previously guided intravenous fluid therapy and been validated as a prognostic biomarker associated with death. The usefulness of post-admission measurements of bl
Externí odkaz:
https://doaj.org/article/1c13af0ae7854f378ae6cea3d2631bb5
Autor:
David Wichman, Geoffrey Guenther, Nthambose M. Simango, Mengxin Yu, Dylan Small, Olivia D. Findorff, Nathaniel O. Amoah, Rohini Dasan, Karl B. Seydel, Douglas G. Postels, Nicole F. O’Brien
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 9, Iss 9, p 210 (2024)
Point-of-care testing (PoCT), an alternative to laboratory-based testing, may be useful in the clinical care of critically ill children in resource-limited settings. We evaluated the clinical utility of PoCT in the care of 193 Malawian children treat
Externí odkaz:
https://doaj.org/article/a5684d0b446f45f7ad4742f6b224f623
Autor:
Madiha Q. Raees, Montfort Benard Gushu, Terrie E. Taylor, Karl B. Seydel, Hunter J. Wynkoop, Nicole F. O’Brien
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionMortality in pediatric cerebral malaria (CM) in low- and middle-income countries (LMICs) is associated with brain swelling on magnetic resonance imaging (MRI); however, MRI is unavailable in most LMICs. Optic nerve sheath diameter (ONSD)
Externí odkaz:
https://doaj.org/article/90a66862b9664bd8a206950411fb31d8
Autor:
Moses B Chilombe, Karl B Seydel, Colleen A Hammond, Suzanna Mwanza, Archana A Patel, Frank Lungu, Somwe Wa Somwe, Sam Kampondeni, Michael J Potchen, Michael P McDermott, Gretchen L Birbeck
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0294823 (2024)
BackgroundDespite eradication efforts, ~135,000 African children sustained brain injuries as a result of central nervous system (CNS) malaria in 2021. Newer antimalarial medications rapidly clear peripheral parasitemia and improve survival, but morta
Externí odkaz:
https://doaj.org/article/115c06c24ee14e3c95ea7b0bd2748aa1
Autor:
Kyle J. Wilson, Amit Dhalla, Yanda Meng, Zhanhan Tu, Yalin Zheng, Priscilla Mhango, Karl B. Seydel, Nicholas A. V. Beare
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-16 (2023)
Abstract Background Cerebral malaria (CM) continues to present a major health challenge, particularly in sub-Saharan Africa. CM is associated with a characteristic malarial retinopathy (MR) with diagnostic and prognostic significance. Advances in ret
Externí odkaz:
https://doaj.org/article/3e1c51cd8f024735b9e39ded5d91cff5
Autor:
Dumizulu Tembo, Visopo Harawa, Tam C. Tran, Louise Afran, Malcolm E. Molyneux, Terrie E. Taylor, Karl B. Seydel, Tonney Nyirenda, David G. Russell, Wilson Mandala
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-16 (2023)
Abstract Background Although pro-inflammatory cytokines are involved in the clearance of Plasmodium falciparum during the early stages of the infection, increased levels of these cytokines have been implicated in the pathogenesis of severe malaria. A
Externí odkaz:
https://doaj.org/article/52f1e7ea82e6445991b2942845a3a8ad
Autor:
Derby Tembo, Suzanna Mwanza, Chisambo Mwaba, Ifunanya Dallah, Somwe wa Somwe, Karl B. Seydel, Gretchen L. Birbeck
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-8 (2022)
Abstract Background Recent research has established that acute kidney injury (AKI) is a common problem in severe paediatric malaria. Limited access to kidney diagnostic studies in the low resources settings where malaria is common has constrained res
Externí odkaz:
https://doaj.org/article/69911d2779eb4f3591ccb64b48fd4e9f