Zobrazeno 1 - 10
of 1 116
pro vyhledávání: '"B Savage"'
Autor:
Alexander J. Farnsworth, Kayla M. Holland, Aaron L. Zaugg, Fetutasi Pauga, Shane M. Drake, Paul B. Savage, James E. Patterson
Publikováno v:
SN Applied Sciences, Vol 5, Iss 12, Pp 1-5 (2023)
Abstract Adhesives play a crucial role in many industries, including medicine, construction, and electronics. In the medical field, additives may be incorporated into adhesives to enhance drug delivery or prevent infection. This study explored the ef
Externí odkaz:
https://doaj.org/article/c01fa22458674c75a816ec1e5eda9b9b
Autor:
Maciej Karasiński, Urszula Wnorowska, Tamara Daniluk, Piotr Deptuła, Milena Łuckiewicz, Paulina Paprocka, Bonita Durnaś, Karol Skłodowski, Beata Sawczuk, Paul B. Savage, Ewelina Piktel, Robert Bucki
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7036 (2024)
A growing body of experimental data indicates that ceragenins (CSAs), which mimic the physicochemical properties of the host’s cationic antimicrobial peptide, hold promise for the development of a new group of broad-spectrum antimicrobials. Here, u
Externí odkaz:
https://doaj.org/article/6a4eaf6add9b4f8ab841ca3db9b17b00
Autor:
Urszula Wnorowska, Dawid Łysik, Ewelina Piktel, Magdalena Zakrzewska, Sławomir Okła, Agata Lesiak, Jakub Spałek, Joanna Mystkowska, Paul B Savage, Paul Janmey, Krzysztof Fiedoruk, Robert Bucki
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298112 (2024)
BackgroundMicrobial biofilms, as a hallmark of cystic fibrosis (CF) lung disease and other chronic infections, remain a desirable target for antimicrobial therapy. These biopolymer-based viscoelastic structures protect pathogenic organisms from immun
Externí odkaz:
https://doaj.org/article/99e5103b6807477fb6b1e5499e7fde33
Autor:
Aiken Dao, Christale Gaitanos, Sumedh Kamble, Omid Sharifahmadian, Richard Tan, Steven G. Wise, Tiffany Lai Yun Cheung, Marcela M.M. Bilek, Paul B. Savage, Aaron Schindeler, Behnam Akhavan
Publikováno v:
Advanced Materials Interfaces, Vol 11, Iss 2, Pp n/a-n/a (2024)
Abstract Covalent biofunctionalization of implant surfaces using anti microbial agents is a promising approach to reducing bone infection and implant failure. Radical‐rich, ion‐assisted plasma polymerized (IPP) coatings enable surface covalent bi
Externí odkaz:
https://doaj.org/article/117e6ac1daa24aaca24abf2abfa6eeb7
Autor:
Karol Skłodowski, Łukasz Suprewicz, Sylwia Joanna Chmielewska-Deptuła, Szczepan Kaliniak, Sławomir Okła, Magdalena Zakrzewska, Łukasz Minarowski, Robert Mróz, Tamara Daniluk, Paul B. Savage, Krzysztof Fiedoruk, Robert Bucki
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The purpose of the work was to investigate the impact of sodium chloride (NaCl) on the antimicrobial efficacy of ceragenins (CSAs) and antimicrobial peptides (AMPs) against bacterial and fungal pathogens associated with cystic fibrosis (CF) lung infe
Externí odkaz:
https://doaj.org/article/d9f8cdf72ad0416e819ef345cc844e6e
Autor:
Michał Czarnowski, Monika Słowińska, Mariusz Sawieljew, Urszula Wnorowska, Tamara Daniluk, Grzegorz Król, Maciej Karasiński, Sławomir Okła, Paul B. Savage, Ewelina Piktel, Robert Bucki
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 204 (2024)
Ensuring proper dental hygiene is of paramount importance for individuals’ general well-being, particularly for patients receiving medical care. There is a prevailing utilization of conventional oral hygiene items, including toothbrushes and mouthw
Externí odkaz:
https://doaj.org/article/5a1ac1ba9ad74aae8beae988a20374d8
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Ceragenins, including CSA-13, are cationic antimicrobials that target the bacterial cell envelope differently than colistin. However, the molecular basis of their action is not fully understood. Here, we examined the genomic and transcriptom
Externí odkaz:
https://doaj.org/article/6845d3223675441a984680e7766a8726
Autor:
Urszula Wnorowska, Ewelina Piktel, Piotr Deptuła, Tomasz Wollny, Grzegorz Król, Katarzyna Głuszek, Bonita Durnaś, Katarzyna Pogoda, Paul B. Savage, Robert Bucki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Ceragenins (CSAs) are synthetic, lipid-based molecules that display activities of natural antimicrobial peptides. Previous studies demonstrated their high in vitro activity against pathogens causing urinary tract infections (UTIs), but their
Externí odkaz:
https://doaj.org/article/e6ffa29d7dee4afd9ff39797f06ac20b
Antimicrobial Activity of Ceragenins against Vancomycin-Susceptible and -Resistant Enterococcus spp.
Autor:
Mayram Hacioglu, Fatima Nur Yilmaz, Ozlem Oyardi, Cagla Bozkurt Guzel, Nese Inan, Paul B. Savage, Sibel Dosler
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1643 (2023)
Ceragenins (CSAs) are a new class of antimicrobial agents designed to mimic the activities of endogenous antimicrobial peptides. In this study, the antibacterial activities of various ceragenins (CSA-13, CSA-44, CSA-90, CSA-131, CSA-138, CSA-142, and
Externí odkaz:
https://doaj.org/article/9a2cbc17bd8b43d5a7144bfe56318264
Autor:
Iva Ganeva, Koini Lim, Jerome Boulanger, Patrick C. Hoffmann, Olivia Muriel, Alicia C. Borgeaud, Wim J.H. Hagen, David B. Savage, Wanda Kukulski
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112107- (2023)
Summary: Lipid droplets (LDs) are intracellular organelles responsible for storing surplus energy as neutral lipids. Their size and number vary enormously. In white adipocytes, LDs can reach 100 μm in diameter, occupying >90% of the cell. Cidec, whi
Externí odkaz:
https://doaj.org/article/00b66045fd06421498677f74309510d4