Computational Structural Pharmacology and Toxicology of Voltage-Gated Sodium Channels

Autor: B S, Zhorov, D B, Tikhonov

Publikováno v: Current topics in membranes. 78

Voltage-gated sodium channels are targets for many toxins and medically important drugs. Despite decades of intensive studies in industry and academia, atomic mechanisms of action are still not completely understood. The major cause is a lack of high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f3361417213ee367f03630c56faa2ad
https://pubmed.ncbi.nlm.nih.gov/27586283

Guanidine Derivatives: Conformation, Capability for Chelation, Study as Reversible Inhibitors of Cholinesterases of Different Origin

Autor: E. V. Rozengart, N. E. Basova, B. S. Zhorov, S. N. Moralev, V. S. Saakov, A. A. Suvorov, A. E. Khovanskikh

Publikováno v: Journal of Evolutionary Biochemistry and Physiology. 39:393-404

Study of spatial structure of biologically active guanidine derivatives by the method of molecular mechanics has shown that in an anticoccidial drug, 1,3-bis ( p-chlorobenzylidenamino)guanidine (Cl-BAG) the most preferable are convolute conformations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::448ff71aa13ca2180181d5996516210c
https://doi.org/10.1023/b:joey.0000010235.00798.98

The Use of 5-Hydroxymethylfurfural (5-HMF) in Multi-Component Hantzsch Dihydropyridine Synthesis.

Autor: Jiang J; INSA Lyon, Université Lyon 1, CNRS, CPE, UMR 5246, ICBMS, 1 rue Victor Grignard, F-69621, Villeurbanne Cedex., Queneau Y; INSA Lyon, Université Lyon 1, CNRS, CPE, UMR 5246, ICBMS, 1 rue Victor Grignard, F-69621, Villeurbanne Cedex., Popowycz F; INSA Lyon, Université Lyon 1, CNRS, CPE, UMR 5246, ICBMS, 1 rue Victor Grignard, F-69621, Villeurbanne Cedex.

Publikováno v: ChemSusChem [ChemSusChem] 2024 Aug 26; Vol. 17 (16), pp. e202301782. Date of Electronic Publication: 2024 Apr 24.

CD, 1H NMR and molecular modeling studies of the interaction of Ca2+ with substance P and Ala7-substance P in a non-polar solvent

Autor: X F, Qi, B S, Zhorov, V S, Ananthanarayanan

Publikováno v: Journal of peptide science : an official publication of the European Peptide Society. 6(2)

The biologically relevant conformation of substance P is likely to be dictated by the lipid milieu wherein the hormone would interact with its receptor. Assuming that specific constraints to the hormone structure may be imparted by its interaction wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5d5b55db7b567b3e3b8fbf691874164
https://pubmed.ncbi.nlm.nih.gov/10718128

[Structure of collagen with a new net of hydrogen bonds]

Autor: Iu V, Mil'chevskiĭ, B S, Zhorov, N G, Esipova, V G, Tumanian

Publikováno v: Bioorganicheskaia khimiia. 25(5)

A conformational variability of the collagen triple helix was studied with the methods of molecular mechanics. The Rich-Crick model with one hydrogen bond per tripeptide fragment or the model with two hydrogen bonds per tripeptide fragment were used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a4da48a6a6732360aaa487ab839366f
https://pubmed.ncbi.nlm.nih.gov/10495892