Zobrazeno 1 - 8
of 8
pro vyhledávání: '"B S, Lutzke"'
Autor:
Douglas W. Harris, John M. Hamlyn, Donald W. DuCharme, James H. Ludens, Michael A. Clark, B. S. Lutzke, F Mandel, D M Sutter, W R Mathews
Publikováno v:
Hypertension. 17:923-929
In previous reports, we described the isolation and characterization of an endogenous digitalislike factor (EDLF). In this report, we describe a unique combination of bioassay and large-scale purification methodology that made possible the purificati
Autor:
J M Braughler, B S Lutzke
Publikováno v:
Journal of Lipid Research, Vol 31, Iss 11, Pp 2127-2130 (1990)
We have developed a simplified and improved high performance liquid chromatography (HPLC) method for the detection and quantitation of tissue lipid using a new laser light-scattering detector (Varex model ELSD II). This detector has a limit of sensit
Autor:
J. N. Duncan, M. W. Smith, Rita M. Huff, Robert A. Lahti, Lawson Cf, Schlachter Sk, Tenbrink Ruth E, Douglas W. Harris, I. J. Martin, B. S. Lutzke, John C. Sih, Rees Sa, C. L. Bergh
Publikováno v:
Journal of Medicinal Chemistry. 39:2435-2437
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(3)
In an accompanying article, an in vitro assay for permeability predicts that membrane-protective, antioxidant 2,4-diamino-pyrrolo[2, 3-d]pyrimidines should have improved blood-brain barrier (BBB) permeation over previously described lipophilic antiox
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(3)
Oxidative stress is considered a cause or propagator of acute and chronic disorders of the central nervous system. Novel 2, 4-diamino-pyrrolo[2,3-d]pyrimidines are potent inhibitors of iron-dependent lipid peroxidation, are cytoprotective in cell cul
Autor:
E D, Hall, P K, Andrus, S L, Smith, T J, Fleck, H M, Scherch, B S, Lutzke, G A, Sawada, J S, Althaus, P F, Vonvoigtlander, G E, Padbury, P G, Larson, J R, Palmer, G L, Bundy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
A novel group of antioxidant compounds, the pyrrolopyrimidines, has been discovered recently. Many of these possess significantly improved oral bioavailability (56-70% in rats), increased efficacy and potency in protecting cultured neurons against ir
Autor:
K M, Merchant, G S, Gill, D W, Harris, R M, Huff, M J, Eaton, K, Lookingland, B S, Lutzke, R B, Mccall, M F, Piercey, P J, Schreur, V H, Sethy, M W, Smith, K A, Svensson, A H, Tang, P F, Vonvoigtlander, R E, Tenbrink
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(3)
Dopamine D2-like receptors play an important role in the pharmacotherapy of psychotic disorders. Molecular and cellular techniques have identified distinct gene products (D2-long, D2-short, D3 and D4) displaying the D2 receptor pharmacology. However,
Autor:
E D, Hall, P K, Andrus, S L, Smith, J A, Oostveen, H M, Scherch, B S, Lutzke, T J, Raub, G A, Sawada, J R, Palmer, L S, Banitt, J S, Tustin, K L, Belonga, D E, Ayer, G L, Bundy
Publikováno v:
Acta neurochirurgica. Supplement. 66
The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of experimental models. Currently, tirilazad is being actively investigated