Zobrazeno 1 - 10
of 12
pro vyhledávání: '"B S, Griffiths"'
Autor:
Simon J. Allison, Jaroslaw Bryk, Christopher J. Clemett, Robert A. Faulkner, Michael Ginger, Hollie B. S. Griffiths, Jane Harmer, P. Jane Owen-Lynch, Emma Pinder, Heiko Wurdak, Roger M. Phillips, Craig R. Rice
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Artificial self-assembling systems such as anion receptors or ‘binders’ are largely unexplored for therapeutic applications. Here, the authors report self-assembling trimetallic cryptands containing copper, zinc or manganese that encapsulate a ra
Externí odkaz:
https://doaj.org/article/5894d27a002d445592149ac898aef1be
Autor:
Emma Pinder, Christopher J. Clemett, Craig R. Rice, Jane Harmer, P. Jane Owen-Lynch, Roger M. Phillips, Hollie B. S. Griffiths, Robert A. Faulkner, Heiko Wurdak, Jarosław Bryk, Michael L. Ginger, Simon J. Allison
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
One topical area of supramolecular chemistry is the binding of anionic species but despite the importance of anions in diverse cellular processes and for cancer development, anion receptors or ‘binders’ have received little attention as potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bd73459fbf77f419b8850047e7b6db
https://doaj.org/article/5894d27a002d445592149ac898aef1be
https://doaj.org/article/5894d27a002d445592149ac898aef1be
Publikováno v:
Biochemical Society Transactions. 48:733-744
Nicotinamide adenine dinucleotide (NAD+) and its reduced form NADH are essential coupled redox metabolites that primarily promote cellular oxidative (catabolic) metabolic reactions. This enables energy generation through glycolysis and mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d238790bf38b1ce97ef751ea8c38f44
https://doi.org/10.1042/bst20190033
https://doi.org/10.1042/bst20190033
Autor:
Farideh A. Javid, Kartheek Sooda, Simon J. Allison, Hollie B. S. Griffiths, Roger M. Phillips, Colin J. Suckling, Ryan J O Nichol, Abedawn I. Khalaf, Omar Khadeer Hussain, Fraser J. Scott
Publikováno v:
MedChemComm. 10:1620-1634
Traditional cytotoxic agents which act through a DNA-alkylating mechanism are relatively non-specific, resulting in a small therapeutic window and thus limiting their effectiveness. In this study, we evaluate a panel of 24 non-alkylating Strathclyde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19df024198cfbbfdfe5b8c2d54346cd
https://doi.org/10.1039/c9md00268e
https://doi.org/10.1039/c9md00268e
Autor:
Ryan J O, Nichol, Abedawn I, Khalaf, Kartheek, Sooda, Omar, Hussain, Hollie B S, Griffiths, Roger, Phillips, Farideh A, Javid, Colin J, Suckling, Simon J, Allison, Fraser J, Scott
Publikováno v:
Medchemcomm
Traditional cytotoxic agents which act through a DNA-alkylating mechanism are relatively non-specific, resulting in a small therapeutic window and thus limiting their effectiveness. In this study, we evaluate a panel of 24 non-alkylating Strathclyde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3be6ff304d22f07b717024cd88fc250
https://pubmed.ncbi.nlm.nih.gov/32952999
https://pubmed.ncbi.nlm.nih.gov/32952999
Autor:
Courtney Williams, Hollie B. S. Griffiths, Heiko Wurdak, Joanne Marrison, Georgia Mavria, Simon J. Allison, Margherita Scarcia, Alastair Droop, Barbara da Silva, Ryan K. Mathew, Euan S. Polson, Jennifer Williams, Peter O'Toole, Lucy F. Stead, Bronwyn K. Irving, Susan C Short
Publikováno v:
Journal of Cell Science.
Tumor stem cells and malignant multicellular networks have been separately implicated in the therapeutic resistance of Glioblastoma Multiforme (GBM), the most aggressive type of brain cancer in adults. We show that small molecule inhibition of RHO-as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f97cc5b76ac8c5a20dd4f6c6300eaba
https://doi.org/10.1242/jcs.228452
https://doi.org/10.1242/jcs.228452
Autor:
Andrew N Holding, Edith M. Ross, Jennifer Williams, Florian Markowetz, Mihaela Lorger, Lee D. Roberts, Euan S. Polson, Hollie B. S. Griffiths, Christopher Abbosh, Verena Kuchler, Stephane Ballereau, Heiko Wurdak, Shoutian Zhu, Paul Chumas, Simon J. Allison, Eulashini Chuntharpursat-Bon, Ryan K. Mathew, Alastair Droop, Hao Shao, Adam J. Davies, Jason E. Gestwicki, Barbara da Silva, Robin S. Bon, Hester A. Beard, Anjana Patel, Susan C Short
Pharmacological inhibition of uncontrolled cell growth with small-molecule inhibitors is a potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary brain cancer. We showed that the synthetic small-molecule KHS101 prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da69000f2995632289b3b1ed5a069a53
https://eprints.whiterose.ac.uk/135396/1/Polson_et_al_2018_AAV.pdf
https://eprints.whiterose.ac.uk/135396/1/Polson_et_al_2018_AAV.pdf
Autor:
Robert A. Faulkner, Craig R. Rice, Owen J. Harper, Roger M. Phillips, David J. Cooke, Samantha L. Shepherd, Simon J. Allison, Richard T. Wheelhouse, Hollie B. S. Griffiths, Omar Khadeer Hussain, Paul I. P. Elliott, Francesca S. Davidson, P. Jane Owen-Lynch
Publikováno v:
Allison, S J, Cooke, D, Davidson, F S, Elliott, P I P, Faulkner, R A, Griffiths, H B S, Harper, O, Hussain, O, Owen-Lynch, P J, Phillips, R M, Rice, C R, Shepherd, S L & Wheelhouse, R T 2018, ' Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells ', Angewandte Chemie-International Edition, vol. 57, no. 31, pp. 9799-9804 . https://doi.org/10.1002/anie.201805510
The ligands L1 and L2 both form separable dinuclear double-stranded helicate and mesocate complexes with RuII . In contrast to clinically approved platinates, the helicate isomer of [Ru2 (L1 )2 ]4+ was preferentially cytotoxic to isogenic cells (HCT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e9edece6e9c1a660ee5a318687a30e
https://pubmed.ncbi.nlm.nih.gov/29863754
https://pubmed.ncbi.nlm.nih.gov/29863754
Autor:
Lee D. Roberts, Adam J. Davies, Edith M. Ross, Euan S. Polson, Jennifer Williams, Florian Markowetz, Barbara da Silva, Shoutian Zhu, Simon J. Allison, Jason E. Gestwicki, Paul Chumas, Alastair Droop, Susan C Short, Hao Shao, Hollie B. S. Griffiths, Robin S. Bon, Eulashini Chuntharpursat-Bon, Ryan K. Mathew, Anjana Patel, Heiko Wurdak, Christopher Abbosh, Mihaela Lorger, Hester A. Beard, Verena Kuchler
Pharmacological inhibition of uncontrolled cell growth with small molecule inhibitors is a potential strategy against glioblastoma multiforme (GBM), the most malignant primary brain cancer. Phenotypic profiling of the neurogenic small molecule KHS101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084cda10d785c9cfacadc6fac93d10f6
Publikováno v:
Antonie van Leeuwenhoek. 73(1)
We have applied a broad-scale approach to the analysis of DNA extracted from soils which support characteristic grasslands at an upland site in the UK. To test for the degree of coherence between microbial and vascular communities, grasslands were ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1ed1955c73558ef823d38651cebb569
https://pubmed.ncbi.nlm.nih.gov/9602274
https://pubmed.ncbi.nlm.nih.gov/9602274