Zobrazeno 1 - 10
of 76
pro vyhledávání: '"B S, Coller"'
Publikováno v:
Blood. 95:368-374
Abnormal interaction of sickle red blood cells (SS RBC) with the vascular endothelium has been implicated as a factor in the initiation of vasoocclusion in sickle cell anemia. Both von Willebrand factor (vWf) and thrombospondin (TSP) play important r
Publikováno v:
Blood. 82:2125-2136
The recently cloned functional thrombin receptor is thought to be activated by thrombin cleavage of the bond between R41 and S42, followed by the insertion of the new N-terminal region (“tethered ligand”) into an unknown site in the receptor. Ant
Autor:
K J Norton, B S Coller, Lesley E. Scudder, Sharon M. West, Jürg H. Beer, Karen T. Springer, N Mohandas
Publikováno v:
Journal of Clinical Investigation. 89:546-555
In an attempt to overcome the limitations and drawbacks of using fresh platelets for transfusion therapy of thrombocytopenic patients, we have performed in vitro experiments on an autologous, semi-artificial alternative to platelet transfusions. Base
Publikováno v:
Europe PubMed Central
The interactions between ligands containing the recognition sequence arginine-glycine-aspartic acid (RGD) and integrin receptors are important in many cell-cell and cell-protein interactions. The platelet contains five integrin receptors and they con
Autor:
N. Andrews, J. E. Burris, T. R. Cech, B. S. Coller, W. F. Crowley, E. K. Gallin, K. L. Kelner, D. G. Kirch, A. I. Leshner, C. D. Morris, F. T. Nguyen, J. Oates, N. S. Sung
Publikováno v:
Science (New York, N.Y.). 324(5929)
Powered by the computational muscle of bioinformatics and the broad perspective of systems biology, advances in biomedical science now have the capacity to transform medicine. Yet to fully realize the health benefits of new scientific insight, we mus
Publikováno v:
Angiogenesis. 3(1)
Angiogenesis plays an essential role in the growth and dissemination of solid tumor cancers. The expression of endothelial cell integrin alpha(v)beta3 has been shown to increase during vascular proliferation associated with human tumors. Selective an
Publikováno v:
Thrombosis and haemostasis. 86(4)
Murine models employing genetically altered mice have the potential to provide important new information about the hemostatic system, but before such data can be extrapolated to humans it is necessary to define the similarities and differences betwee
Autor:
B S, Coller
Publikováno v:
Thrombosis and haemostasis. 86(1)
Three platelet glycoprotein (GP) IIb/IIIa receptor antagonists have been approved as adjunctive therapy to decrease the ischemic complications of percutaneous coronary interventions (PCI) and/or unstable angina. They include the chimeric murine/human
Publikováno v:
Thrombosis and haemostasis. 84(6)
The alphaIIbeta3 receptor (GPIIb/IIIa) is the only platelet-specific integrin receptor and the most abundant adhesion/aggregation receptor on the surface of human platelets. Since mice are increasingly being used as models of human disease, we analyz