EFEKTIFITAS TEH KULIT BUAH MANGGIS (Garcinia mangostana L) SEBAGAI ANTIMIKROBA TERHADAP PERTUMBUHAN BAKTERI METHICILLIN RESISTANT Staphylococcus aureus (MRSA)

Autor: Pancawati Ariami, IGAN Danuyanti, B Ryan Anggreni

Publikováno v: Jurnal Teknologi Laboratorium, Vol 3, Iss 1, Pp 1-6 (2014)

Latar Belakang: Pengobatan Methicillin resistant Staphylococcus aureus (MRSA) selain dengan Vankomisin yang relatif mahal dan menimbulkan efek samping, dapat digunakan obat alternatif misalnya kulit buah manggis yang mengandung senyawa xanthone yang

Externí odkaz: https://doaj.org/article/14d5809aa1894a1b93fb4091a3babf83

Actin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology

Autor: Joshua Jackson, Christian Hoffmann, Enzo Scifo, Han Wang, Lena Wischhof, Antonia Piazzesi, Mrityunjoy Mondal, Hanna Shields, Xuesi Zhou, Magali Mondin, Eanna B. Ryan, Hermann Döring, Jochen H. M. Prehn, Klemens Rottner, Gregory Giannone, Pierluigi Nicotera, Dan Ehninger, Dragomir Milovanovic, Daniele Bano

Publikováno v: Cell Death and Disease, Vol 15, Iss 4, Pp 1-17 (2024)

Abstract Abnormal intraneuronal accumulation of soluble and insoluble α-synuclein (α-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well documented that the reversible liquid-liq

Externí odkaz: https://doaj.org/article/997bb81463e54820a4534745f1061001

Beyond the Imitation Game: Quantifying and extrapolating the capabilities of language models

Autor: Srivastava, Aarohi, Rastogi, Abhinav, Rao, Abhishek, Shoeb, Abu Awal Md, Abid, Abubakar, Fisch, Adam, Brown, Adam R., Santoro, Adam, Gupta, Aditya, Garriga-Alonso, Adrià, Kluska, Agnieszka, Lewkowycz, Aitor, Agarwal, Akshat, Power, Alethea, Ray, Alex, Warstadt, Alex, Kocurek, Alexander W., Safaya, Ali, Tazarv, Ali, Xiang, Alice, Parrish, Alicia, Nie, Allen, Hussain, Aman, Askell, Amanda, Dsouza, Amanda, Slone, Ambrose, Rahane, Ameet, Iyer, Anantharaman S., Andreassen, Anders, Madotto, Andrea, Santilli, Andrea, Stuhlmüller, Andreas, Dai, Andrew, La, Andrew, Lampinen, Andrew, Zou, Andy, Jiang, Angela, Chen, Angelica, Vuong, Anh, Gupta, Animesh, Gottardi, Anna, Norelli, Antonio, Venkatesh, Anu, Gholamidavoodi, Arash, Tabassum, Arfa, Menezes, Arul, Kirubarajan, Arun, Mullokandov, Asher, Sabharwal, Ashish, Herrick, Austin, Efrat, Avia, Erdem, Aykut, Karakaş, Ayla, Roberts, B. Ryan, Loe, Bao Sheng, Zoph, Barret, Bojanowski, Bartłomiej, Özyurt, Batuhan, Hedayatnia, Behnam, Neyshabur, Behnam, Inden, Benjamin, Stein, Benno, Ekmekci, Berk, Lin, Bill Yuchen, Howald, Blake, Orinion, Bryan, Diao, Cameron, Dour, Cameron, Stinson, Catherine, Argueta, Cedrick, Ramírez, César Ferri, Singh, Chandan, Rathkopf, Charles, Meng, Chenlin, Baral, Chitta, Wu, Chiyu, Callison-Burch, Chris, Waites, Chris, Voigt, Christian, Manning, Christopher D., Potts, Christopher, Ramirez, Cindy, Rivera, Clara E., Siro, Clemencia, Raffel, Colin, Ashcraft, Courtney, Garbacea, Cristina, Sileo, Damien, Garrette, Dan, Hendrycks, Dan, Kilman, Dan, Roth, Dan, Freeman, Daniel, Khashabi, Daniel, Levy, Daniel, González, Daniel Moseguí, Perszyk, Danielle, Hernandez, Danny, Chen, Danqi, Ippolito, Daphne, Gilboa, Dar, Dohan, David, Drakard, David, Jurgens, David, Datta, Debajyoti, Ganguli, Deep, Emelin, Denis, Kleyko, Denis, Yuret, Deniz, Chen, Derek, Tam, Derek, Hupkes, Dieuwke, Misra, Diganta, Buzan, Dilyar, Mollo, Dimitri Coelho, Yang, Diyi, Lee, Dong-Ho, Schrader, Dylan, Shutova, Ekaterina, Cubuk, Ekin Dogus, Segal, Elad, Hagerman, Eleanor, Barnes, Elizabeth, Donoway, Elizabeth, Pavlick, Ellie, Rodola, Emanuele, Lam, Emma, Chu, Eric, Tang, Eric, Erdem, Erkut, Chang, Ernie, Chi, Ethan A., Dyer, Ethan, Jerzak, Ethan, Kim, Ethan, Manyasi, Eunice Engefu, Zheltonozhskii, Evgenii, Xia, Fanyue, Siar, Fatemeh, Martínez-Plumed, Fernando, Happé, Francesca, Chollet, Francois, Rong, Frieda, Mishra, Gaurav, Winata, Genta Indra, de Melo, Gerard, Kruszewski, Germán, Parascandolo, Giambattista, Mariani, Giorgio, Wang, Gloria, Jaimovitch-López, Gonzalo, Betz, Gregor, Gur-Ari, Guy, Galijasevic, Hana, Kim, Hannah, Rashkin, Hannah, Hajishirzi, Hannaneh, Mehta, Harsh, Bogar, Hayden, Shevlin, Henry, Schütze, Hinrich, Yakura, Hiromu, Zhang, Hongming, Wong, Hugh Mee, Ng, Ian, Noble, Isaac, Jumelet, Jaap, Geissinger, Jack, Kernion, Jackson, Hilton, Jacob, Lee, Jaehoon, Fisac, Jaime Fernández, Simon, James B., Koppel, James, Zheng, James, Zou, James, Kocoń, Jan, Thompson, Jana, Wingfield, Janelle, Kaplan, Jared, Radom, Jarema, Sohl-Dickstein, Jascha, Phang, Jason, Wei, Jason, Yosinski, Jason, Novikova, Jekaterina, Bosscher, Jelle, Marsh, Jennifer, Kim, Jeremy, Taal, Jeroen, Engel, Jesse, Alabi, Jesujoba, Xu, Jiacheng, Song, Jiaming, Tang, Jillian, Waweru, Joan, Burden, John, Miller, John, Balis, John U., Batchelder, Jonathan, Berant, Jonathan, Frohberg, Jörg, Rozen, Jos, Hernandez-Orallo, Jose, Boudeman, Joseph, Guerr, Joseph, Jones, Joseph, Tenenbaum, Joshua B., Rule, Joshua S., Chua, Joyce, Kanclerz, Kamil, Livescu, Karen, Krauth, Karl, Gopalakrishnan, Karthik, Ignatyeva, Katerina, Markert, Katja, Dhole, Kaustubh D., Gimpel, Kevin, Omondi, Kevin, Mathewson, Kory, Chiafullo, Kristen, Shkaruta, Ksenia, Shridhar, Kumar, McDonell, Kyle, Richardson, Kyle, Reynolds, Laria, Gao, Leo, Zhang, Li, Dugan, Liam, Qin, Lianhui, Contreras-Ochando, Lidia, Morency, Louis-Philippe, Moschella, Luca, Lam, Lucas, Noble, Lucy, Schmidt, Ludwig, He, Luheng, Colón, Luis Oliveros, Metz, Luke, Şenel, Lütfi Kerem, Bosma, Maarten, Sap, Maarten, ter Hoeve, Maartje, Farooqi, Maheen, Faruqui, Manaal, Mazeika, Mantas, Baturan, Marco, Marelli, Marco, Maru, Marco, Quintana, Maria Jose Ramírez, Tolkiehn, Marie, Giulianelli, Mario, Lewis, Martha, Potthast, Martin, Leavitt, Matthew L., Hagen, Matthias, Schubert, Mátyás, Baitemirova, Medina Orduna, Arnaud, Melody, McElrath, Melvin, Yee, Michael A., Cohen, Michael, Gu, Michael, Ivanitskiy, Michael, Starritt, Michael, Strube, Michael, Swędrowski, Michał, Bevilacqua, Michele, Yasunaga, Michihiro, Kale, Mihir, Cain, Mike, Xu, Mimee, Suzgun, Mirac, Walker, Mitch, Tiwari, Mo, Bansal, Mohit, Aminnaseri, Moin, Geva, Mor, Gheini, Mozhdeh, T, Mukund Varma, Peng, Nanyun, Chi, Nathan A., Lee, Nayeon, Krakover, Neta Gur-Ari, Cameron, Nicholas, Roberts, Nicholas, Doiron, Nick, Martinez, Nicole, Nangia, Nikita, Deckers, Niklas, Muennighoff, Niklas, Keskar, Nitish Shirish, Iyer, Niveditha S., Constant, Noah, Fiedel, Noah, Wen, Nuan, Zhang, Oliver, Agha, Omar, Elbaghdadi, Omar, Levy, Omer, Evans, Owain, Casares, Pablo Antonio Moreno, Doshi, Parth, Fung, Pascale, Liang, Paul Pu, Vicol, Paul, Alipoormolabashi, Pegah, Liao, Peiyuan, Liang, Percy, Chang, Peter, Eckersley, Peter, Htut, Phu Mon, Hwang, Pinyu, Miłkowski, Piotr, Patil, Piyush, Pezeshkpour, Pouya, Oli, Priti, Mei, Qiaozhu, Lyu, Qing, Chen, Qinlang, Banjade, Rabin, Rudolph, Rachel Etta, Gabriel, Raefer, Habacker, Rahel, Risco, Ramon, Millière, Raphaël, Garg, Rhythm, Barnes, Richard, Saurous, Rif A., Arakawa, Riku, Raymaekers, Robbe, Frank, Robert, Sikand, Rohan, Novak, Roman, Sitelew, Roman, LeBras, Ronan, Liu, Rosanne, Jacobs, Rowan, Zhang, Rui, Salakhutdinov, Ruslan, Chi, Ryan, Lee, Ryan, Stovall, Ryan, Teehan, Ryan, Yang, Rylan, Singh, Sahib, Mohammad, Saif M., Anand, Sajant, Dillavou, Sam, Shleifer, Sam, Wiseman, Sam, Gruetter, Samuel, Bowman, Samuel R., Schoenholz, Samuel S., Han, Sanghyun, Kwatra, Sanjeev, Rous, Sarah A., Ghazarian, Sarik, Ghosh, Sayan, Casey, Sean, Bischoff, Sebastian, Gehrmann, Sebastian, Schuster, Sebastian, Sadeghi, Sepideh, Hamdan, Shadi, Zhou, Sharon, Srivastava, Shashank, Shi, Sherry, Singh, Shikhar, Asaadi, Shima, Gu, Shixiang Shane, Pachchigar, Shubh, Toshniwal, Shubham, Upadhyay, Shyam, Shyamolima, Debnath, Shakeri, Siamak, Thormeyer, Simon, Melzi, Simone, Reddy, Siva, Makini, Sneha Priscilla, Lee, Soo-Hwan, Torene, Spencer, Hatwar, Sriharsha, Dehaene, Stanislas, Divic, Stefan, Ermon, Stefano, Biderman, Stella, Lin, Stephanie, Prasad, Stephen, Piantadosi, Steven T., Shieber, Stuart M., Misherghi, Summer, Kiritchenko, Svetlana, Mishra, Swaroop, Linzen, Tal, Schuster, Tal, Li, Tao, Yu, Tao, Ali, Tariq, Hashimoto, Tatsu, Wu, Te-Lin, Desbordes, Théo, Rothschild, Theodore, Phan, Thomas, Wang, Tianle, Nkinyili, Tiberius, Schick, Timo, Kornev, Timofei, Tunduny, Titus, Gerstenberg, Tobias, Chang, Trenton, Neeraj, Trishala, Khot, Tushar, Shultz, Tyler, Shaham, Uri, Misra, Vedant, Demberg, Vera, Nyamai, Victoria, Raunak, Vikas, Ramasesh, Vinay, Prabhu, Vinay Uday, Padmakumar, Vishakh, Srikumar, Vivek, Fedus, William, Saunders, William, Zhang, William, Vossen, Wout, Ren, Xiang, Tong, Xiaoyu, Zhao, Xinran, Wu, Xinyi, Shen, Xudong, Yaghoobzadeh, Yadollah, Lakretz, Yair, Song, Yangqiu, Bahri, Yasaman, Choi, Yejin, Yang, Yichi, Hao, Yiding, Chen, Yifu, Belinkov, Yonatan, Hou, Yu, Hou, Yufang, Bai, Yuntao, Seid, Zachary, Zhao, Zhuoye, Wang, Zijian, Wang, Zijie J., Wang, Zirui, Wu, Ziyi

Publikováno v: Transactions on Machine Learning Research, May/2022, https://openreview.net/forum?id=uyTL5Bvosj

Language models demonstrate both quantitative improvement and new qualitative capabilities with increasing scale. Despite their potentially transformative impact, these new capabilities are as yet poorly characterized. In order to inform future resea

Externí odkaz: http://arxiv.org/abs/2206.04615

Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input

Autor: Michael B. Ryan, Allison E. Girasole, Andrew J. Flores, Emily L. Twedell, Matthew M. McGregor, Rea Brakaj, Ronald F. Paletzki, Thomas S. Hnasko, Charles R. Gerfen, Alexandra B. Nelson

Publikováno v: Cell Reports, Vol 43, Iss 8, Pp 114483- (2024)

Summary: The striatum integrates dopaminergic and glutamatergic inputs to select preferred versus alternative actions. However, the precise mechanisms underlying this process remain unclear. One way to study action selection is to understand how it b

Externí odkaz: https://doaj.org/article/825603252a4c4ae58da19f1e6899922c

Development and evaluation of an algorithm to link mothers and infants in two US commercial healthcare claims databases for pharmacoepidemiology research

Autor: James Weaver, Jill H. Hardin, Clair Blacketer, Alexis A. Krumme, Melanie H. Jacobson, Patrick B. Ryan

Publikováno v: BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-15 (2023)

Abstract Background Administrative healthcare claims databases are used in drug safety research but are limited for investigating the impacts of prenatal exposures on neonatal and pediatric outcomes without mother-infant pair identification. Further,

Externí odkaz: https://doaj.org/article/5fc7e4c598b0499d836aec6fa12c9b36