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Akademický článek

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Wnt-1 Regulates Free Pools of Catenins and Stabilizes APC-Catenin Complexes

Autor: B Rubinfeld, B Schryver, P Polakis, J Papkoff

Publikováno v: Molecular and Cellular Biology. 16:2128-2134

The Wnt-1 proto-oncogene induces the accumulation of beta-catenin and plakoglobin, two related proteins that associate with and functionally modulate the cadherin cell adhesion proteins. Here we have investigated the effects of Wnt-1 expression on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afab596b6f7cb28881d11391cac9a75
https://doi.org/10.1128/mcb.16.5.2128

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From genes to proteins: high-throughput expression and purification of the human proteome

Autor: J S, Albala, K, Franke, I R, McConnell, K L, Pak, P A, Folta, B, Rubinfeld, A H, Davies, G G, Lennon, R, Clark

Publikováno v: Journal of cellular biochemistry. 80(2)

The development of high-throughput methods for gene discovery has paved the way for the design of new strategies for genome-scale protein analysis. Lawrence Livermore National Laboratory and Onyx Pharmaceuticals, Inc., have produced an automatable sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a198e16a697072abf7b951325309e0be
https://pubmed.ncbi.nlm.nih.gov/11074586

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Defects in the regulation of beta-catenin in colorectal cancer

Autor: P, Polakis, M, Hart, B, Rubinfeld

Publikováno v: Advances in experimental medicine and biology. 470

The molecular events that contribute to the progression of colon cancer are beginning to unravel. An initiating and probably obligatory event is the oncogenic activation of beta-catenin. This can come about by the loss of its negative regulator the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df391e2debb16ebf3ca395188c54c7b4
https://pubmed.ncbi.nlm.nih.gov/10709671

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Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene

Autor: B, Rubinfeld, I, Albert, E, Porfiri, S, Munemitsu, P, Polakis

Publikováno v: Cancer research. 57(20)

The mutation cluster region in the APC gene defines a region of approximately 660 bp, in which the vast majority of its somatic mutations are found. These mutations disrupt the polypeptide chain, typically eliminating five of the seven repeated seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80cec0a39a2414dbcebf4042b55345bb
https://pubmed.ncbi.nlm.nih.gov/9377578

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Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage

Autor: J E, Thomas, M, Smith, J L, Tonkinson, B, Rubinfeld, P, Polakis

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 8(7)

BRCA1, the familial breast cancer susceptibility gene product, is a 220-kDA phosphorylated protein. BRCA1 immunoprecipitated from MCF7 cells blocked in G1-S phase or progressing through S-phase of the cell cycle migrated more slowly through SDS polya

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::852ef5db3f267475a0db51fd437ec803
https://pubmed.ncbi.nlm.nih.gov/9218874

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Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression

Autor: Masakazu Hattori, Hiroshi Kubota, B. Rubinfeld, H. Maruta, Noriyuki Tsukamoto, M. S. A. Nur-E-Kamal, Nagahiro Minato, Kazuhiro Iwai

Publikováno v: Molecular and cellular biology. 15(1)

We have cloned a novel cDNA (Spa-1) which is little expressed in the quiescent state but induced in the interleukin 2-stimulated cycling state of an interleukin 2-responsive murine lymphoid cell line by differential hybridization. Spa-1 mRNA (3.5 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5e060eb34666c921c7e66ae40499a1
https://pubmed.ncbi.nlm.nih.gov/7799964

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Purification of baculovirus-produced Rap1 GTPase-activating protein

Autor: B, Rubinfeld, P, Polakis

Publikováno v: Methods in enzymology. 255

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de72d4e9be476b98fbbd90293064542f
https://pubmed.ncbi.nlm.nih.gov/8524116

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The APC gene product associates with microtubules in vivo and promotes their assembly in vitro

Autor: S, Munemitsu, B, Souza, O, Müller, I, Albert, B, Rubinfeld, P, Polakis

Publikováno v: Cancer research. 54(14)

Defects in the APC gene occur frequently in patients with familial adenomatous polyposis coli and are associated with the progression of sporadic tumors of the colon and stomach. We examined the subcellular location of adenomatous polyposis coli (APC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33b2a64d8858e1f588de55b639dbc326
https://pubmed.ncbi.nlm.nih.gov/8033083

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