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Akademický článek

Diminished responses to mRNA-based SARS-CoV-2 vaccines in individuals with rheumatoid arthritis on immune-modifying therapies

Autor: Samuel D. Klebanoff, Lauren B. Rodda, Chihiro Morishima, Mark H. Wener, Yevgeniy Yuzefpolskiy, Estelle Bettelli, Jane H. Buckner, Cate Speake, Marion Pepper, Daniel J. Campbell

Publikováno v: JCI Insight, Vol 8, Iss 15 (2023)

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that causes debilitating swelling and destruction of the joints. People with RA are treated with drugs that actively suppress one or more parts of their immune system, and these

Externí odkaz: https://doaj.org/article/13459b7a9d15424893fed20f19913b0c

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Cytotoxic T Cells Targeting Spike Glycoprotein Are Associated with Hybrid Immunity to SARS-CoV-2

Autor: Jolie M. Phan, Erik D. Layton, Krystle K. Q. Yu, Melissa S. Aguilar, Inah Golez, Nicholas M. Franko, Jennifer K. Logue, Lauren B. Rodda, Christian A. Howard, Marion Pepper, Michael Gale, Helen Y. Chu, Chetan Seshadri

Publikováno v: The Journal of Immunology. 210:1236-1246

mRNA vaccination of individuals with prior SARS-CoV-2 infection provides superior protection against breakthrough infections with variants of concern compared with vaccination in the absence of prior infection. However, the immune mechanisms by which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2de9ba0557f0e71e3ba41800649e3bc
https://doi.org/10.4049/jimmunol.2200815

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IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2

Publikováno v: The Journal of experimental medicine. 219(9)

Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from convalescent donors or an engineered monoclonal antibody (mAb) product. While pentameric IgM antibodies are responsible for much of convalescent sera’s neutralizing capaci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2ad5a20085cb3b87ebd4b689c5e4a4
https://pubmed.ncbi.nlm.nih.gov/36036783

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Akademický článek

Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node

Autor: Yang Zhang, Theodore L Roth, Elizabeth E Gray, Hsin Chen, Lauren B Rodda, Yin Liang, Patrick Ventura, Saul Villeda, Paul R Crocker, Jason G Cyster

Publikováno v: eLife, Vol 5 (2016)

Lymph nodes (LNs) contain innate-like lymphocytes that survey the subcapsular sinus (SCS) and associated macrophages for pathogen entry. The factors promoting this surveillance behavior have not been defined. Here, we report that IL7RhiCcr6+ lymphocy

Externí odkaz: https://doaj.org/article/2da01033d465472ca35a3fc8b158696a

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CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells

Autor: Dan Liu, Lihui Duan, Lauren B. Rodda, Erick Lu, Ying Xu, Jinping An, Longhui Qiu, Fengchun Liu, Mark R. Looney, Zhiyong Yang, Christopher D. C. Allen, Zhongmei Li, Alexander Marson, Jason G. Cyster

Publikováno v: Science
Science (New York, N.Y.), vol 375, iss 6581

Dendritic cells (DCs) are crucial for initiating adaptive immune responses. However, the factors that control DC positioning and homeostasis are incompletely understood. We found that type-2 conventional DCs (cDC2s) in the spleen depend on Gα 13 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb38bda5f98c39d8e7e2120695a8ba1
https://doi.org/10.1126/science.abi5965

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Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity

Autor: Lauren B. Rodda, Peter A. Morawski, Kurt B. Pruner, Mitchell L Fahning, Christian A. Howard, Nicholas Franko, Jennifer Logue, Julie Eggenberger, Caleb Stokes, Inah Golez, Malika Hale, Michael Gale, Helen Y. Chu, Daniel J. Campbell, Marion Pepper

SummaryImmune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in which nascent memory could be tracked through additional antigen expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c29b3ef85a2159e96524909932bc24
https://doi.org/10.1101/2022.01.12.22269192

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Metabolic constraints on the B cell response to malaria

Autor: Lauren B. Rodda, Marion Pepper

Publikováno v: Nature Immunology. 21:722-724

Early plasmablasts responding to Plasmodium infection may outcompete germinal center B cells for l-glutamine and delay pathogen control.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86b405beb7358f4b8c5b8c3fa6fa6f8b
https://doi.org/10.1038/s41590-020-0718-1

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Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

Publikováno v: Research Square
article-version (status) pre
article-version (number) 1
Cell

The SARS-CoV-2 virus is causing a global pandemic and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f96f0c73740575efc8f305b85b0ec9
https://pubmed.ncbi.nlm.nih.gov/32818218

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Functional SARS-CoV-2-specific immune memory persists after mild COVID-19

Publikováno v: medRxiv

SummaryThe recently emerged SARS-CoV-2 virus is currently causing a global pandemic and cases continue to rise. The majority of infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85035c382474ae4765e0ba21e72655d

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