Zobrazeno 1 - 10
of 20
pro vyhledávání: '"B R, Champion"'
Publikováno v:
Hybridoma. 14:383-390
Mouse monoclonal antibodies against recombinant human fibroblast procollagenase and prostromelysin have been generated and characterized. The epitope-containing domains for the antibodies have been assigned based on their immunoreactivities against r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47a710b42541729f8d282eec18c65b2
https://doi.org/10.1089/hyb.1995.14.383
https://doi.org/10.1089/hyb.1995.14.383
Autor:
B R Champion, Anne Cooke, M Geysen, G Biswas-Hughes, K Page, I M Roitt, N Parish, K Dawe, D C Rayner
Publikováno v:
The Journal of Experimental Medicine
Although thyroglobulin (Tg), the thyroid prohormone, is well known as a T cell dependent autoantigen in human and experimental autoimmune thyroid disease, very little is known about the molecular basis of Tg recognition by T cells. In this paper, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d374c61c93e9cbd98050cb7f4fc3aeb
https://doi.org/10.1084/jem.174.2.363
https://doi.org/10.1084/jem.174.2.363
Publikováno v:
Immunological reviews. 182
Notch signalling plays a critical role in embryogenesis, influencing the differentiation and growth of a variety of cell types across the species. In the mammalian immune system, Notch signalling operates at various levels; it controls the differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c730d3dc841029ea6031abbca1564c5
https://pubmed.ncbi.nlm.nih.gov/11722637
https://pubmed.ncbi.nlm.nih.gov/11722637
Autor:
G D McIntyre, Katherine E. Kilpatrick, Bruce Caterson, S A Wring, D H Walker, M D Macklin, Jui-Lan Su, B R Champion, J A Payne
Publikováno v:
Hybridoma. 16(4)
Affinity matured murine monoclonal antibody producing cell lines can now be rapidly generated using a novel repetitive, multiple site immunization strategy designated RIMMS. RIMMS capitalizes on rapid hypermutation and affinity maturation events whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e300750e713040e26ff8872f18ceedfe
https://pubmed.ncbi.nlm.nih.gov/9309429
https://pubmed.ncbi.nlm.nih.gov/9309429
Publikováno v:
BioTechniques. 22(2)
We have developed a rapid in situ screening procedure that enables prescreening of hundreds of hybridomas in a 96-well format. The procedure involves fluorescence immunostaining of cells cultured in 96-well plates and the use of a fluorescence plate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80773221942f0bb8069a84552ec59215
https://pubmed.ncbi.nlm.nih.gov/9043705
https://pubmed.ncbi.nlm.nih.gov/9043705
SUMMARY Elevation of intracellular cAMP levels has been shown previously to inhibit cytokine secretion by various cell types in vitro. Since salmeterol is a β2-agonist which activates adenylate cyclase, its ability to inhibit cytokine production was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6346319987433d05566e15dcd43ec88
https://europepmc.org/articles/PMC1534196/
https://europepmc.org/articles/PMC1534196/
Publikováno v:
Immunology series. 59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c86c811d1315df8226ced0bc0a153c8b
https://pubmed.ncbi.nlm.nih.gov/8461398
https://pubmed.ncbi.nlm.nih.gov/8461398
Publikováno v:
The Journal of Experimental Medicine
A synthetic peptide based on a sequence containing thyroxine at position 2553 in thyroglobulin (Tg), and already shown to be recognized by two clonotypically distinct murine Tg autoreactive T cell hybridomas, can trigger primed lymph node cells to tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8048e4371f634eba649b9880e217d330
https://pubmed.ncbi.nlm.nih.gov/1740668
https://pubmed.ncbi.nlm.nih.gov/1740668
Publikováno v:
Immunology. 69(4)
Non-human primates have been used to study immune function to a much lesser extent than readily available strains of inbred rodents. Nevertheless, in situations where it might be desirable, but impossible, to study human immune responses in vivo, low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a501be105fb018e11622e4527aed1aed
https://pubmed.ncbi.nlm.nih.gov/2110549
https://pubmed.ncbi.nlm.nih.gov/2110549
Publikováno v:
The Journal of Immunology. 139:3665-3670
We have used two clonotypically distinct thyroglobulin (Tg)-specific, I-Ak restricted monoclonal T cell populations to investigate the role of thyroid peroxidase-catalyzed iodination in Tg recognition by autoreactive T cells. The results showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22d0f7c1d3a9cfe14e042cbb178c2609
https://doi.org/10.4049/jimmunol.139.11.3665
https://doi.org/10.4049/jimmunol.139.11.3665