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Akademický článek

Clinical, Virologic, Immunologic Outcomes and Emerging HIV Drug Resistance Patterns in Children and Adolescents in Public ART Care in Zimbabwe.

Autor: A T Makadzange, M Higgins-Biddle, B Chimukangara, R Birri, M Gordon, T Mahlanza, G McHugh, J H van Dijk, M Bwakura-Dangarembizi, T Ndung'u, C Masimirembwa, B Phelps, A Amzel, B O Ojikutu, B D Walker, C E Ndhlovu

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144057 (2015)

To determine immunologic, virologic outcomes and drug resistance among children and adolescents receiving care during routine programmatic implementation in a low-income country.A cross-sectional evaluation with collection of clinical and laboratory

Externí odkaz: https://doaj.org/article/6a82f232a0c7444394480bd11542f91a

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Akademický článek

Profiling cells with DELs: Small molecule fingerprinting of cell surfaces

Autor: Jason Deng, Svetlana Belyanskaya, Ninad Prabhu, Christopher Arico-Muendel, Hongfeng Deng, Christopher B. Phelps, David I. Israel, Hongfang Yang, Joseph Boyer, G. Joseph Franklin, Jeremy L. Yap, Kenneth E. Lind, Ching-Hsuan Tsai, Christine Donahue, Jennifer D. Summerfield

Publikováno v: SLAS Discovery, Vol 29, Iss 5, Pp 100171- (2024)

DNA-encoded small molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, it has been used to identify ligands against targets that are soluble or overexpressed on cell surfaces. Here,

Externí odkaz: https://doaj.org/article/200cb0758edc446ea0423cf022c88bf1

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Long-term safety of spinal cord stimulation systems in a prospective, global registry of patients with chronic pain

Autor: Richard L Rauck, Eric Loudermilk, Simon J Thomson, Jose Francisco Paz-Solis, Louis Bojrab, John Noles, Jan Vesper, Joseph Atallah, Daniel Roth, Joseph Hegarty, Michel Prud'Homme, Gregory M Phillips, Stephen G Smith, Mohab Ibrahim, Channing D Willoughby, Jon B Obray, Mayank Gupta, Julio Paez, Anthony P Berg, Nathan J Harrison, Paolo Maino, Praveen Mambalam, Matthew McCarty, Glyn Towlerton, Sarah Love-Jones, Shakil Ahmed, Albert Lee, Binit Shah, Itay Goor-Aryeh, Marc A Russo, Nicolas Varela, Jeffrey B Phelps, José Cid, Tacson Fernandez, Concepción Pérez-Hernández, Douglas Keehn, Joshua M Rosenow, Nameer Haider, Andrew G Parrent, Melinda M Lawrence, Peter Georgius, Laura Demartini, Agustin Mendiola, Vivek Mehta, Reinhard Thoma, Atef F Israel, Giuliano De Carolis, Sanjay Bhatia, Matthew Green, Armando Villarreal, Matthew T Crooks, Ryder P Gwinn, Julie G Pilitsis, Hitoaki Sato, Sergio Maldonado Vega, M. Gabriel Hillegass, Paul Carnes, Christian Scherer, Silviu Brill, James Yu, James J Brennan, Kliment Gatzinsky, Annu Navani, Lee T Snook Jr, Borja Mugabure Bujedo, Javier De Andrés Ares, Abel Murillo, Andrew T Trobridge, Kamyar Assil, Jawad Shah, Carroll McLeod, Joseph Buwembo, Olivier De Coster, Nathan Miller, Mehendra Sanapati, Medhat Mikhael, Rene Przkora, Norihiko Sukenaga, Louis J Raso, Aaron K Calodney, Luz Elena Cáceres Jerez, Takuya Uchiyama, Jan-Willem Kallewaard, Brett Chandler, Fabián Piedimonte, Kenneth D Candido, Tristan E Weaver, Takashi Agari, David Holthouse, Rex Woon, Nileshkumar Patel, Kristen Lechleiter, Roshini Jain

Publikováno v: Pain Management. 13:115-127

Aim: The availability of long-term (>2 years) safety outcomes of spinal cord stimulation (SCS) remains limited. We evaluated safety in a global SCS registry for chronic pain. Methods: Participants were prospectively enrolled globally at 79 implanting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5fce9a0b933ec3535d9a8c609684f49
https://doi.org/10.2217/pmt-2022-0091

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Akademický článek

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Autor: Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and anti

Externí odkaz: https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887

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Akademický článek

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MITF deficiency and oncogenic GNAQ each promote proliferation programs in zebrafish melanocyte lineage cells

Autor: Grace B. Phelps, Adam Amsterdam, Hannah R. Hagen, Nicole Zambrana García, Jacqueline A. Lees

Publikováno v: Pigment Cell & Melanoma Research. 35:539-547

Uveal melanoma (UM) is the most common primary malignancy of the adult eye but lacks any FDA-approved therapy for the deadly metastatic disease. Thus, there is a great need to dissect the driving mechanisms for UM and develop strategies to evaluate p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f86738ccb62ae9f8db05707df2ed83
https://doi.org/10.1111/pcmr.13057

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Children with severe sepsis: relationship between community level income and morbidity and mortality

Autor: Kayla B. Phelps, Acham Gebremariam, Erica Andrist, Ryan P. Barbaro, Gary L. Freed, Erin F. Carlton

Publikováno v: Pediatric Research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dacaa7797701dbba1c8907e752e15e96
https://doi.org/10.1038/s41390-023-02500-w

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Akademický článek

Baseline cultural competence in physician assistant students.

Autor: Melanie M Domenech Rodríguez, Paula B Phelps, H Cathleen Tarp

Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0215910 (2019)

PurposeCultural competence is a critical component in health care services. The relationship between health disparities and prejudice and discrimination is well documented. Prejudicial attitudes and discriminatory behavior are modifiable through trai

Externí odkaz: https://doaj.org/article/51b8c79426684c4a9f9483c114be4966

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