Zobrazeno 1 - 10
of 669
pro vyhledávání: '"B Pernis"'
Autor:
Rosa J. Chen, Anika Nabila, Swati Phalke, Danny Flores Castro, Judit Gal Toth, Paul Bergin, Jeroen Bastiaans, Heidi Stuhlmann, Alessandra B. Pernis, Miklos Toth
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105595- (2022)
Summary: Serotonin-1A receptor (5HT1AR) is highly expressed in corticolimbic regions and its deficit is associated with anxiety and depression. A similar reduction in 5HT1AR heterozygous knockout (Het) mice results in anxiety-like and increased stres
Externí odkaz:
https://doaj.org/article/8bdba824be5b48fd9f993aee9b4e912d
Autor:
Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF)
Externí odkaz:
https://doaj.org/article/908466dd2bb34f6fa842dde7cbf2d877
Autor:
Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M. Eisenhaure, Shuqiang Li, Edward P. Browne, Adam Chicoine, Danielle Sutherby, Akiko Noma, Accelerating Medicines Partnership RA/SLE Network, Chad Nusbaum, Stephen Kelly, Alessandra B. Pernis, Lionel B. Ivashkiv, Susan M. Goodman, William H. Robinson, Paul J. Utz, James A. Lederer, Ellen M. Gravallese, Brendan F. Boyce, Nir Hacohen, Costantino Pitzalis, Peter K. Gregersen, Gary S. Firestein, Soumya Raychaudhuri, Larry W. Moreland, V. Michael Holers, Vivian P. Bykerk, Andrew Filer, David L. Boyle, Michael B. Brenner, Jennifer H. Anolik
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims
Externí odkaz:
https://doaj.org/article/f1834e16a4ee4cddb44b1feb039eb118
Autor:
Woelsung Yi, Sanjay Gupta, Edd Ricker, Michela Manni, Rolf Jessberger, Yurii Chinenov, Henrik Molina, Alessandra B. Pernis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Excessive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of TFH cells in mice via alteration of mTOR
Externí odkaz:
https://doaj.org/article/d8898e9c90074000ad87e4d3b1cd931c
Autor:
Zhu Chen, Danny Flores Castro, Sanjay Gupta, Swati Phalke, Michela Manni, Juan Rivera‐Correa, Rolf Jessberger, Habib Zaghouani, Eugenia Giannopoulou, Tania Pannellini, Alessandra B. Pernis
Publikováno v:
Arthritis & Rheumatology. 74:1544-1555
Age-associated/autoimmune B cells (ABCs) are an emerging B cell subset with aberrant expansion in systemic lupus erythematosus. ABC generation and differentiation exhibit marked sexual dimorphism, and Toll-like receptor 7 (TLR-7) engagement is a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced9a0cb9bf4b464785b75f399a6e83f
https://doi.org/10.1002/art.42146
https://doi.org/10.1002/art.42146
Data from An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas
Autor:
Ari M. Melnick, Wendy Béguelin, Alessandra B. Pernis, Hans Christian Reinhardt, David W. Scott, Christian Steidl, Qiang Pan-Hammarström, Xiaofei Ye, Christopher E. Mason, Edd Ricker, Gero Knittel, Cem Meydan, Christopher R. Chin, Matt Teater, Andrew Lytle, Yusuke Isshiki, Dylan R. McNally, Min Xia, Ioannis Karagiannidis, Julia Hansen, Ruth Flümann, Benedikt W. Pelzer, Martin A. Rivas, Leandro Venturutti
A third of patients with diffuse large B-cell lymphoma (DLBCL) present with extranodal dissemination, which is associated with inferior clinical outcomes. MYD88L265P is a hallmark extranodal DLBCL mutation that supports lymphoma proliferation. Yet ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e748b5a771bb5a07991a21f3b1e878
https://doi.org/10.1158/2159-8290.c.6549789
https://doi.org/10.1158/2159-8290.c.6549789
Autor:
Ari M. Melnick, Wendy Béguelin, Alessandra B. Pernis, Hans Christian Reinhardt, David W. Scott, Christian Steidl, Qiang Pan-Hammarström, Xiaofei Ye, Christopher E. Mason, Edd Ricker, Gero Knittel, Cem Meydan, Christopher R. Chin, Matt Teater, Andrew Lytle, Yusuke Isshiki, Dylan R. McNally, Min Xia, Ioannis Karagiannidis, Julia Hansen, Ruth Flümann, Benedikt W. Pelzer, Martin A. Rivas, Leandro Venturutti
Supplementary Table S1 - Differentially expressed genes and PAGE analysis in Myd88 L252P GCB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088a639da9ab7465c8b1e80e6ea5c852
https://doi.org/10.1158/2159-8290.22542042.v1
https://doi.org/10.1158/2159-8290.22542042.v1
Autor:
Ari M. Melnick, Wendy Béguelin, Alessandra B. Pernis, Hans Christian Reinhardt, David W. Scott, Christian Steidl, Qiang Pan-Hammarström, Xiaofei Ye, Christopher E. Mason, Edd Ricker, Gero Knittel, Cem Meydan, Christopher R. Chin, Matt Teater, Andrew Lytle, Yusuke Isshiki, Dylan R. McNally, Min Xia, Ioannis Karagiannidis, Julia Hansen, Ruth Flümann, Benedikt W. Pelzer, Martin A. Rivas, Leandro Venturutti
Gating strategies, validation of results using alternative models or definitions, QC controls, etc.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87649a42ca03ca72300c01d4c878452
https://doi.org/10.1158/2159-8290.22542045.v1
https://doi.org/10.1158/2159-8290.22542045.v1
Autor:
Daniel Jenkins, Swati Phalke, Richard Bell, Samantha Lessard, Sanjay Gupta, Mark Youssef, Kathleen Tam, Allina Nocon, Juan Rivera‐Correa, Timothy Wright, Thomas Sculco, Miguel Otero, Alessandra B. Pernis, Peter Sculco
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research SocietyREFERENCES.
Dissatisfaction occurs in nearly 20% of patients after total knee arthroplasty (TKA); however, there remains only limited understanding of the biologic mechanisms that may contribute to suboptimal postoperative outcomes requiring revision surgery. Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e9e43825f085bb04dcc71c94dc78f2
https://pubmed.ncbi.nlm.nih.gov/36121317
https://pubmed.ncbi.nlm.nih.gov/36121317
Publikováno v:
F1000Research, Vol 5 (2016)
Effective immune responses require the precise regulation of dynamic interactions between hematopoietic and non-hematopoietic cells. The Rho subfamily of GTPases, which includes RhoA, is rapidly activated downstream of a diverse array of biochemical
Externí odkaz:
https://doaj.org/article/c9bf9040b6a840bc8f98c784bceeba11