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Bolus injection of aqueous antigen leads to a high density of T‐cell‐receptor ligand in the spleen, transient T‐cell activation and anergy induction

Autor: B P Wallner, S K Switzer, M Luqman, T J Briner, G H Sunshine, C R Bourque

Publikováno v: Immunology. 94:513-522

In vivo anergy can be modelled by administration of soluble peptide to T-cell receptor (TCR) transgenic mice specific for the moth cytochrome c peptide 88-103 (MCCp). Two weeks after initial peptide treatment, T cells were present in normal numbers b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df73b54e82c053be8f085834079b4366
https://doi.org/10.1046/j.1365-2567.1998.00554.x

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Experimental autoimmune encephalomyelitis induced with a combination of myelin basic protein and myelin oligodendrocyte glycoprotein is ameliorated by administration of a single myelin basic protein peptide

Autor: E A, Leadbetter, C R, Bourque, B, Devaux, C D, Olson, G H, Sunshine, S, Hirani, B P, Wallner, D E, Smilek, M P, Happ

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(1)

Multiple sclerosis is an autoimmune disease of the central nervous system in which T cell reactivity to several myelin proteins, including myelin basic protein (MBP), proteolipid protein, and myelin oligodendrocyte glycoprotein (MOG), has been implic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5ca93b5f533439d6a4d5925d368ac5b
https://pubmed.ncbi.nlm.nih.gov/9647262

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The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms

Autor: C H Lilley, B P Wallner, M T Kasaian, Rob C. Aalberse, C B Bizinkauskas, J P Morgenstern, J F Bond, A W Brauer, A Konieczny

Publikováno v: Immunology. 92(4)

Canis familiaris allergen 1 (Can f 1) and Canis familiaris allergen 2 (Can f 2) are the two major allergens present in dog dander extracts. We now report the isolation of cDNAs encoding both proteins and present their nucleotide and deduced amino aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3f6da0a85b2f15510a04fd29cb016e
https://pubmed.ncbi.nlm.nih.gov/9497502

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Short course single agent therapy with an LFA-3-IgG1 fusion protein prolongs primate cardiac allograft survival

Autor: R J, Kaplon, P S, Hochman, R E, Michler, P A, Kwiatkowski, N M, Edwards, C L, Berger, H, Xu, W, Meier, B P, Wallner, P, Chisholm, C C, Marboe

Publikováno v: Transplantation. 61(3)

The interaction of T cell costimulatory molecules with their ligands is required for optimal T cell activation. Interference with such interactions can induce antigen unresponsiveness and delay xeno- and allograft rejection. We have previously shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7c9eaeac638b2d224425ab246664914
https://pubmed.ncbi.nlm.nih.gov/8610340

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The increased potency of cross-linked lymphocyte function-associated antigen-3 (LFA-3) multimers is a direct consequence of changes in valency

Autor: R B, Pepinsky, L L, Chen, W, Meier, B P, Wallner

Publikováno v: The Journal of biological chemistry. 266(27)

We have used chemically cross-linked dimers, trimers, and tetramers of lymphocyte function-associated antigen-3 (LFA-3) to study the role of multivalency in the interaction of the protein with its receptor, CD2. The cross-linked adducts showed enhanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fb1a89c129d14d05e5d189e4dac9c57
https://pubmed.ncbi.nlm.nih.gov/1717445

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Studies on the structural properties of lipocortin-1 and the regulation of its synthesis by steroids

Autor: J L, Browning, M P, Ward, B P, Wallner, R B, Pepinsky

Publikováno v: Progress in clinical and biological research. 349

Lipocortin-1 protein synthesis in resting monocytes is under the control of glucocorticoid steroids. This induction occurs at reasonable dexamethasone concentrations, may require concomitant synthesis of transcriptional factors, appears to be cell ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9242ed4487010f5ab81589a4593248da
https://pubmed.ncbi.nlm.nih.gov/2144640

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Chromosomal localization of the human genes for lipocortin I and lipocortin II

Autor: K, Huebner, L A, Cannizzaro, A Z, Frey, B K, Hecht, F, Hecht, C M, Croce, B P, Wallner

Publikováno v: Oncogene research. 2(4)

The human genes which code for Lipocortin I and Lipocortin II, proteins that inhibit phospholipase A2 (PLA2) activity, have been regionally localized in the human genome by chromosomal in situ hybridization and segregation analysis in somatic cell hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98008538e4ddae8e83d1908bdbe161fc
https://pubmed.ncbi.nlm.nih.gov/2969496

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Purification and partial sequence analysis of a 37-kDa protein that inhibits phospholipase A2 activity from rat peritoneal exudates

Autor: R B, Pepinsky, L K, Sinclair, J L, Browning, R J, Mattaliano, J E, Smart, E P, Chow, T, Falbel, A, Ribolini, J L, Garwin, B P, Wallner

Publikováno v: The Journal of biological chemistry. 261(9)

We have purified from rat peritoneal exudates a 37-kDa protein that inhibits phospholipase A2 activity. It is the predominant phospholipase inhibitor protein in these preparations and also is detected in a wide variety of cell lines. Levels of expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c2711b7f77e34643cf52fa7fd04f0ee
https://pubmed.ncbi.nlm.nih.gov/3081518

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