Zobrazeno 1 - 10
of 35
pro vyhledávání: '"B P Schimmer"'
Publikováno v:
Journal of Biological Chemistry. 265:11713-11720
The cholesterol side-chain cleavage enzyme (SCC) catalyzes the initial and rate-limiting step in the synthesis of steroid hormones. The mouse gene encoding SCC was cloned and the nucleotide sequence of its 5'-flanking region determined. This sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7435627a4ba51e74c51ba61e09fbfe0
https://doi.org/10.1016/s0021-9258(19)38455-8
https://doi.org/10.1016/s0021-9258(19)38455-8
Publikováno v:
Journal of Biological Chemistry. 265:8052-8058
Steroid 21-hydroxylase (21-OHase) is specifically expressed at high levels in the adrenal cortex, where it is required for the synthesis of mineralocorticoids and glucocorticoids. In this study, we have investigated the regulatory elements in the 21-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce2b3f08b406859e88af0f1adeecbab1
https://doi.org/10.1016/s0021-9258(19)39037-4
https://doi.org/10.1016/s0021-9258(19)39037-4
Publikováno v:
American Journal of Physiology-Cell Physiology. 258:C1036-C1043
This study characterized the various adenosine 3',5'-cyclic monophosphate (cAMP)-binding proteins in epithelial cells cultured from human sweat glands to identify potential pathways of cAMP action in this tissue. The cAMP-binding proteins were identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef6da9ac6ad793a0f2a813328be4bda
https://doi.org/10.1152/ajpcell.1990.258.6.c1036
https://doi.org/10.1152/ajpcell.1990.258.6.c1036
Autor:
K L, Parker, B P, Schimmer
Publikováno v:
Reviews in endocrinemetabolic disorders. 2(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ec19d8eb410815ab1a8391bbe3a6220
https://pubmed.ncbi.nlm.nih.gov/11705131
https://pubmed.ncbi.nlm.nih.gov/11705131
Publikováno v:
Journal of cellular physiology. 166(3)
This study demonstrates that the isolated regulatory (R) domain (amino acids 1-270) of human protein kinase C alpha (PKC alpha) is a potent inhibitor of PKC beta-I activity in a yeast expression system. The PKC alpha R domain fused to glutathione-S-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b66dfcfbe3b2c402bdf07e404d3049a
https://pubmed.ncbi.nlm.nih.gov/8600165
https://pubmed.ncbi.nlm.nih.gov/8600165
Autor:
K L, Parker, B P, Schimmer
Publikováno v:
Vitamins and hormones. 51
Steroid hormone biosynthesis requires the concerted action of a related group of cytochrome P-450 steroid hydroxylases. In recent years considerable effort has been directed toward defining the molecular basis for the cell-selective expression of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d96b62ad48df9ddeb00ca59e11c0f230
https://pubmed.ncbi.nlm.nih.gov/7483327
https://pubmed.ncbi.nlm.nih.gov/7483327
Autor:
K L, Parker, B P, Schimmer
Publikováno v:
Seminars in cancer biology. 5(5)
Epidemiological studies implicate steroid hormones as important factors in the development of neoplasia, and hormonal manipulation constitutes an important treatment arm in cancer therapy. Recent studies demonstrate a key role for nuclear receptor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53bb0fb37ea177fb021aaaf6afdd85dd
https://pubmed.ncbi.nlm.nih.gov/7849260
https://pubmed.ncbi.nlm.nih.gov/7849260
Publikováno v:
The Journal of biological chemistry. 265(20)
The cholesterol side-chain cleavage enzyme (SCC) catalyzes the initial and rate-limiting step in the synthesis of steroid hormones. The mouse gene encoding SCC was cloned and the nucleotide sequence of its 5'-flanking region determined. This sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac6fe083e644b1c682c50686a4d958a2
https://pubmed.ncbi.nlm.nih.gov/2365694
https://pubmed.ncbi.nlm.nih.gov/2365694
Publikováno v:
The Journal of biological chemistry. 265(14)
Steroid 21-hydroxylase (21-OHase) is specifically expressed at high levels in the adrenal cortex, where it is required for the synthesis of mineralocorticoids and glucocorticoids. In this study, we have investigated the regulatory elements in the 21-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8d2e8c0707d174ed63c8f3296ab89b8
https://pubmed.ncbi.nlm.nih.gov/2335516
https://pubmed.ncbi.nlm.nih.gov/2335516
Publikováno v:
Journal of Biological Chemistry. 264:14011-14015
In Y1 mouse adrenocortical tumor cells, expression of steroid 11 beta-hydroxylase (11 beta-OHase) is stimulated by cAMP following a delay of 4-6 h. Our results demonstrate that a cAMP-responsive element (CRE) within the 11 beta-OHase promoter region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c42cd40ca88f6b3ce238decad45c377
https://doi.org/10.1016/s0021-9258(18)71634-7
https://doi.org/10.1016/s0021-9258(18)71634-7