Zobrazeno 1 - 10
of 50
pro vyhledávání: '"B P Doctor"'
Autor:
B. P. Doctor, Ashima Saxena, Benjamin R. Capacio, Irwin Koplovitz, Carl T. Olson, Chunyuan Luo, David E. Lenz, Douglas M. Cerasoli, Connie R. Clark, James M. Federko, Donald M. Maxwell
Publikováno v:
Chemico-Biological Interactions. :205-210
Human butyrylcholinesterase (HuBuChE), purified from outdated human plasma, is being evaluated for efficacy against nerve agents in guinea pigs and cynomolgus monkeys. Previous studies in rodents and nonhuman primates demonstrated that pretreatment o
Autor:
Petek K. Chiang, Jacov Tal, B. P. Doctor, K. Pardhasaradhi, Peter P. McCann, G. C. Zeng, Richard K. Gordon
Publikováno v:
The FASEB Journal. 10:471-480
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be tak
Publikováno v:
Journal of Biological Chemistry. 266:7481-7487
Three distinct classes of membrane-bound acetylcholinesterases (AChEs) have been identified. A12 AChE is composed of 12 catalytic subunits that are linked to noncatalytic collagen-like subunits through intersubunit disulfide bonds. G2 AChE is localiz
Autor:
D M, Cerasoli, E M, Griffiths, B P, Doctor, A, Saxena, J M, Fedorko, N H, Greig, Q S, Yu, Y, Huang, H, Wilgus, C N, Karatzas, I, Koplovitz, D E, Lenz
Publikováno v:
Chemico-biological interactions.
Previous studies in rodents and nonhuman primates have demonstrated that pretreatment with cholinesterases can provide significant protection against behavioral and lethal effects of nerve agent intoxication. Human butyrylcholinesterase (HuBuChE) pur
Publikováno v:
Chemico-biological interactions.
We investigated whether transcriptional inducers could enhance the expression of acetylcholinesterase (AChE) in cell lines to achieve protection against organophosphate (OP) poisoning. Trichostatin A (TSA), an inhibitor of histone deacetylase that de
Publikováno v:
Chemico-biological interactions.
Human serum butyrylcholinesterase (Hu BChE) has been demonstrated to be a highly effective detoxifying enzyme for counteracting the acute toxicity of organophosphorus (OP) nerve agents. In order to initiate an investigational new drug (IND) applicati
Publikováno v:
Chemico-Biological Interactions. :409-410
We investigated whether transcriptional inducers could enhance the expression of acetylcholinesterase (AChE) in cell lines to achieve protection against organophosphate (OP) poisoning. Trichostatin A (TSA), an inhibitor of histone deacetylase that de
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 10(4)
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be tak
Publikováno v:
Molecular pharmacology. 44(6)
The monoclonal antibody AE-2, raised against the human erythrocyte acetylcholinesterase (AChE) dimer (acetylcholine acetylhydrolase, EC 3.1.1.7), binds to other mammalian AChEs, including the tetramer that occurs in fetal bovine serum (FBS). AE-2 par
Publikováno v:
Protein science : a publication of the Protein Society. 2(3)
Based on the recently determined X-ray structures of Torpedo californica acetylcholinesterase and Geotrichum candidum lipase and on their three-dimensional superposition, an improved alignment of a collection of 32 related amino acid sequences of oth