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Effects of clofibric and beclobric acid in rat and monkey hepatocyte primary culture: influence on peroxisomal and mitochondrial beta-oxidation and the activity of catalase, glutathione S-transferase and glutathione peroxidase

Autor: Heleen M. Wortelboer, G. A. M. Hassing, Bas J. Blaauboer, B. P. Schmid, K. van Sandwijk, W.C. Mennes, A. Timmerman, U. Jahn

Publikováno v: Archives of toxicology. 68(8)

The effect of hypolipidaemic compounds on peroxisomal fatty acid β-oxidation and on peroxisome morphology in the liver differs widely between rodent and primate species. We studied the relative importance of peroxisomal and mitochondrial β-oxidatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a08fe9eed31e7647e3cc86fbb118c42
https://pubmed.ncbi.nlm.nih.gov/7802591

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The effect of beclobric acid and clofibric acid on peroxisomal beta-oxidation and peroxisome proliferation in primary cultures of rat, monkey and human hepatocytes

Autor: A.A.J. van Iersel, J. F. van Pelt, W.C. Mennes, F.N.A.M. van Pelt, R. Bleumink, Sing Hiem Yap, Bas J. Blaauboer, B. P. Schmid, A. Timmerman, C. W. M. Vdan Holsteijn

Publikováno v: Biochemical pharmacology. 40(3)

The peroxisome-proliferating effects of clofibric acid and beclobric acid were studied in primary cultures of hepatocytes derived from rat, monkey (Macaca fascicularis) and human liver. Determination of peroxisomal fatty acid beta-oxidation and morph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4273907f0ebd45043d5f20c47240b1e9
https://pubmed.ncbi.nlm.nih.gov/2383284

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DNA-damaging potential of diethylstilbestrol evaluated in the germ cell unscheduled dna synthesis assay

Autor: B. P. Schmid, R. R. Racine

Publikováno v: Environmental Mutagenesis. 6:211-218

Despite the fact that the nonsteroidal estrogen diethylstilbestrol (DES) exerts its toxic effects primarily on the reproductive system, little is known about the possible interference of this compound with germ cell DNA. The measurement of unschedule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2bb56185d1c8da61251e79b0f9a696
https://doi.org/10.1002/em.2860060209

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Postimplantation embryo culture for the assessment of the teratogenic potential and potency of compounds

Autor: B P Schmid, L Cicurel

Publikováno v: Experientia. 44:833-840

Whole rat embryos cultured during the early stages of organogenesis were subjected to a panel of selected chemicals. Of seventeen known in vivo teratogens, seventeen also induced specific malformations in embryos grown in culture. Of ten chemicals wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f317e42369b0ec94db5a0bec9dec42
https://doi.org/10.1007/bf01941180

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Effects of cyproheptadine on the rat yolk sac membrane and embryonic development in vitro

Autor: R. E. Hauser, P. Donatsch, B. P. Schmid

Publikováno v: Xenobiotica. 15:695-699

Electron-microscopic examinations of rat embryonic yolk sacs treated in vitro with 1.5 X 10(-5) M cyproheptadine showed proliferation of the lysosomal structures; other organelles remained unaffected, and also overall yolk-sac growth and vascularizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f645f5c574feef97801147c9b8ecea
https://doi.org/10.3109/00498258509047429

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Post-implantation embryo culture: validation with selected compounds for teratogenicity testing

Autor: B. P. Schmid, L. Cicurel

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 18(6)

1. Some chemical compounds selected by experts for the validation of in vitro teratogenicity testing were investigated in whole rat embryos cultured during the early stages of organogenesis. All sixteen known in vivo teratogens tested also induced sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379eaec23c292e4db551718c9eed190d
https://pubmed.ncbi.nlm.nih.gov/3420940

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In Vitro Mouse Fertilization as an Experimental Model for the Monitoring of Adverse Effects on Gametes and Gamete Fusion

Autor: B. P. Schmid, R. R. Racine

Publikováno v: Archives of Toxicology ISBN: 9783540124528

In vitro fertilization of mice gametes is frequently used to assess different factors that disturb human in vitro fertilization, as almost identical conditions prevail for both species. The mouse in vitro fertilization technique was considered to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6379902a56849a2275149cb6ace494b0
https://doi.org/10.1007/978-3-642-69132-4_111

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Xenobiotic influences on embryonic differentiation, growth and morphology in vitro

Autor: B. P. Schmid

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 15(8-9)

Direct in vitro exposure of post-implantation rat embryos to 18 known teratogens induced typical malformations in all cases. Of 21 non-teratogens in vivo, 20 induced, in vitro either no malformations at all, even at high concentrations, or abnormal d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b63eb4434ef32b394262f760a970805
https://pubmed.ncbi.nlm.nih.gov/4072259

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