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Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes

Autor: C, Pfleger, A, Kaas, L, Hansen, B, Alizadeh, P, Hougaard, R, Holl, H, Kolb, B O, Roep, H B, Mortensen, N C, Schloot, Jan Aman, Aman

Publikováno v: Pfleger, C, Kaas, A, Hansen, L, Alizadeh, B, Hougaard, P, Holl, R, Kolb, H, Roep, B O, Mortensen, H B, Schloot, N C & Hvidøre Study Group on Childhood Diabetes 2008, ' Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes ', Clinical Immunology, vol. 128, no. 1, pp. 57-65 . https://doi.org/10.1016/j.clim.2008.03.458
Clinical Immunology, 128(1), 57-65. ACADEMIC PRESS INC ELSEVIER SCIENCE
Clinical Immunology. ACADEMIC PRESS INC ELSEVIER SCIENCE
Clinical Immunology, 128(1), 57-65. San Diego, CA: Academic Press (2008).

Th1 related chemokines CCL3 and CCL5 and Th2 related CCL4 as ligands of the receptor CCR5 contribute to disease development in animal models of type 1 diabetes. In humans, no data are available addressing the role of these chemokines regarding diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e845b058937df1b22c07f6af0d5f9f
https://doi.org/10.1016/j.clim.2008.03.458

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HLA-DQ polymorphism and degree of heteroplasmy of the A3243G mitochondrial DNA mutation in maternally inherited diabetes and deafness

Autor: Johannes A Maassen, B. O. Roep, Leen M 't Hart, E. H. R. Van Essen, J. J. Jansen, Herman H.P.J. Lemkes, J. M. W. van den Ouweland

Publikováno v: Diabetic Medicine. 17:841-847

SUMMARY Aim Maternally inherited diabetes and deafness (MIDD) associates with a mutation at position 3243 in mitochondrial DNA. Phenotypic expression of MIDD includes Type 1-like and Type 2-like diabetes. This study examined whether HLA-DQ phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c496f0bad9ea0190edf2f18c78363a1
https://doi.org/10.1046/j.1464-5491.2000.00379.x

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Circulating forms of ICAM-3 (cICAM-3). Elevated levels in autoimmune diseases and lack of association with cICAM-1

Autor: S Martin, P Rieckmann, I Melchers, R Wagner, J Bertrams, A E Voskuyl, B O Roep, J Zielasek, E Heidenthal, I Weichselbraun

Publikováno v: The Journal of Immunology. 154:1951-1955

The intercellular adhesion molecule-3 (ICAM-3) has been identified as the third LFA-1 ligand in addition to ICAM-1 and ICAM-2. In this report we have identified circulating forms of ICAM-3 (cICAM-3) in human serum. Using a sandwich ELISA with two mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a72aa63670137c9c15a46e2d44fd60e2
https://doi.org/10.4049/jimmunol.154.4.1951

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Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

Autor: A, Kaas, C, Pfleger, A V, Kharagjitsingh, N C, Schloot, L, Hansen, K, Buschard, B P C, Koeleman, B O, Roep, H B, Mortensen, B Z, Alizadeh, Jan, Åman

Publikováno v: Diabetic medicine : a journal of the British Diabetic Association. 29(6)

The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes.Two hundred and twenty-seven patients from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad93aa6a5cb6757de916882111b6bc9b
https://pubmed.ncbi.nlm.nih.gov/22150609

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Association of adiponectin, interleukin (IL)-1ra, inducible protein 10, IL-6 and number of islet autoantibodies with progression patterns of type 1 diabetes the first year after diagnosis

Autor: A, Kaas, C, Pfleger, L, Hansen, K, Buschard, N C, Schloot, B O, Roep, H B, Mortensen, Jan, Aman

Publikováno v: Clinical and Experimental Immunology, 161(3), 444-452

P>The progression of type 1 diabetes after diagnosis is poorly understood. Our aim was to assess the relation of disease progression of juvenile-onset type 1 diabetes, determined by preserved beta cell function the first year after diagnosis, with sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99559a7aae85dadb4f6c3d4d333710a
https://pubmed.ncbi.nlm.nih.gov/20529086

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Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus

Autor: Stephan Martin, S. Kappler, Pejman Hanifi-Moghaddam, Hubert Kolb, B. O. Roep, Sylvia Müller-Scholze, Klaus Strassburger, Nanette C. Schloot, J. Seissler

Publikováno v: Diabetic medicine : a journal of the British Diabetic Association. 23(2)

Aims The hypothesis was tested in an exploratory study that individuals at high risk of developing Type 1 diabetes mellitus have altered systemic levels of cytokines and chemokines. Subjects and methods Forty-two non-diabetic first-degree relatives o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b70c14ea8be4f7ef9078aafa611e131
https://pubmed.ncbi.nlm.nih.gov/16433713

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