Zobrazeno 1 - 10
of 149
pro vyhledávání: '"B Nebiyou Bekele"'
Autor:
Bingbing Dai, Shaoyu Yan, Humberto Lara-Guerra, Hiroyuki Kawashima, Ryo Sakai, Gitanjali Jayachandran, Mourad Majidi, Reza Mehran, Jing Wang, B Nebiyou Bekele, Veerabhadran Baladandayuthapani, Suk-Young Yoo, Ying Wang, Jun Ying, Feng Meng, Lin Ji, Jack A Roth
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0123967 (2015)
Expression of the tumor suppressor gene TUSC2 is reduced or absent in most lung cancers and is associated with worse overall survival. In this study, we restored TUSC2 gene expression in several wild type EGFR non-small cell lung cancer (NSCLC) cell
Externí odkaz:
https://doaj.org/article/4b0fbfba8b0c41f0b85418d2f59eecb8
Autor:
Jieru Meng, Mourad Majidi, Bingliang Fang, Lin Ji, B Nebiyou Bekele, John D Minna, Jack A Roth
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77067 (2013)
TUSC2-defective gene expression is detected in the majority of lung cancers and is associated with worse overall survival. We analyzed the effects of TUSC2 re-expression on tumor cell sensitivity to the AKT inhibitor, MK2206, and explored their mutua
Externí odkaz:
https://doaj.org/article/8994cc1801404ca8b0c882f491cd5ba7
Autor:
Jieru Meng, Bingbing Dai, Bingliang Fang, B Nebiyou Bekele, William G Bornmann, Duoli Sun, Zhenghong Peng, Roy S Herbst, Vassiliki Papadimitrakopoulou, John D Minna, Michael Peyton, Jack A Roth
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14124 (2010)
AZD6244 and MK2206 are targeted small-molecule drugs that inhibit MEK and AKT respectively. The efficacy of this combination in lung cancer is unknown. Our previous work showed the importance of activated AKT in mediating resistance of non-small cell
Externí odkaz:
https://doaj.org/article/5a2c9bf45d224b3b8e13b8bd8bb0bb5d
Autor:
Ignacio I. Wistuba, David J. Stewart, John D. Minna, B. Nebiyou Bekele, Stephen G. Swisher, Shyam Biswal, Alejandro H. Corvalan, Cesar A. Moran, Natalie C. Ozburn, Milind Suraokar, Wenli Dong, Carmen Behrens, Luisa M. Solis
Purpose: To understand the role of nuclear factor erythroid-2–related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) in non–small cell lung cancer (NSCLC), we studied their expression in a large series of tumors with annotated cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083100a91f248871728adf6131aafb57
https://doi.org/10.1158/1078-0432.c.6519359.v1
https://doi.org/10.1158/1078-0432.c.6519359.v1
Autor:
Ignacio I. Wistuba, Lin Ji, Jack A. Roth, Cesar Moran, John D. Minna, B. Nebiyou Bekele, Natalie C. Ozburn, Xian Zhou, Diane D. Liu, Carmen Behrens, Ludmila Prudkin
Supplementary Data from Loss and Reduction of Fus1 Protein Expression is a Frequent Phenomenon in the Pathogenesis of Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e7270394bda4169642c159aaabcdda
https://doi.org/10.1158/1078-0432.22441305.v1
https://doi.org/10.1158/1078-0432.22441305.v1
Autor:
Ignacio I. Wistuba, David J. Stewart, John D. Minna, B. Nebiyou Bekele, Stephen G. Swisher, Shyam Biswal, Alejandro H. Corvalan, Cesar A. Moran, Natalie C. Ozburn, Milind Suraokar, Wenli Dong, Carmen Behrens, Luisa M. Solis
Supplementary Data from Nrf2 and Keap1 Abnormalities in Non–Small Cell Lung Carcinoma and Association with Clinicopathologic Features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f861a813e133bdac07f3bdc59969ec3
https://doi.org/10.1158/1078-0432.22442687
https://doi.org/10.1158/1078-0432.22442687
Autor:
John V. Heymach, Patrick Y. Wen, Michael Prados, WKA Yung, Alice Chen, Kevin Camphausen, Lisa DeAngelis, Andrew Lassman, H. Ian Robins, Minesh Mehta, Tim Cloughesy, B. Nebiyou Bekele, Jun Liu, Hua-Kang Wu, Mark Gilbert, Hai Tran, Yuji Piao, John F. de Groot
Purpose: VEGF and infiltrating myeloid cells are known regulators of tumor angiogenesis and vascular permeability in glioblastoma. We investigated potential blood-based markers associated with radiographic changes to aflibercept, which binds VEGF and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba4ea884f7fa65c6ce14e5cf4c92e6c
https://doi.org/10.1158/1078-0432.c.6519194
https://doi.org/10.1158/1078-0432.c.6519194
Autor:
Ignacio I. Wistuba, Lin Ji, Jack A. Roth, Cesar Moran, John D. Minna, B. Nebiyou Bekele, Natalie C. Ozburn, Xian Zhou, Diane D. Liu, Carmen Behrens, Ludmila Prudkin
Purpose:FUS1, a novel tumor-suppressor gene located in the chromosome 3p21.3 region, may play an important role in lung cancer development. Currently, FUS1-expressing nanoparticles have been developed for treating patients with lung cancer. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96624489b75c12738ecea80fdc56512b
https://doi.org/10.1158/1078-0432.c.6518397.v1
https://doi.org/10.1158/1078-0432.c.6518397.v1
Autor:
John V. Heymach, Patrick Y. Wen, Michael Prados, WKA Yung, Alice Chen, Kevin Camphausen, Lisa DeAngelis, Andrew Lassman, H. Ian Robins, Minesh Mehta, Tim Cloughesy, B. Nebiyou Bekele, Jun Liu, Hua-Kang Wu, Mark Gilbert, Hai Tran, Yuji Piao, John F. de Groot
Supplementary Figure 1 from Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0800d1e19657b62848eda43f68aa9a4c
https://doi.org/10.1158/1078-0432.22442477.v1
https://doi.org/10.1158/1078-0432.22442477.v1
Autor:
Juan Fueyo, Candelaria Gomez-Manzano, W.K. Alfred Yung, B. Nebiyou Bekele, Gregory N. Fuller, Kenneth D. Aldape, Marta M. Alonso, Jing Xu, Hong Jiang, David G. Johnson, Melissa V. Olson
Supplementary Figure 1a movie from Transgenic E2F1 Expression in the Mouse Brain Induces a Human-Like Bimodal Pattern of Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27094f9d8f422a77e77f8e45e6ffb1e6
https://doi.org/10.1158/0008-5472.22367672.v1
https://doi.org/10.1158/0008-5472.22367672.v1