Výsledky vyhledávání - "B N, Kholodenko"

[Kinetic modeling of energy metabolism and generation of active forms of oxygen in hepatocyte mitochondria]

Autor: O V, Demin, I I, Gorianin, B N, Kholodenko, H V, Westerhoff

Publikováno v: Molekuliarnaia biologiia. 35(6)

Direct nonenzymatic oxidation of semiquinone by oxygen is one of the main sources of superoxide radicals (O2.-) in mitochondria. By using all the known data on hepatocyte mitochondria, we have revealed the correlation between the rate of superoxide g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23f42147764785eb3718a53e06d1915b
https://pubmed.ncbi.nlm.nih.gov/11771135

Zobrazit plný text záznamu

Diffusion control of protein phosphorylation in signal transduction pathways

Autor: B N, Kholodenko, G C, Brown, J B, Hoek

Publikováno v: The Biochemical journal.

Multiple signalling proteins are phosphorylated and dephosphorylated at separate cellular locations, which potentially causes spatial gradients of phospho-proteins within the cell. We have derived relationships that enable us to estimate the extent t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0a3f0960645767e864c03561ee095ca
https://pubmed.ncbi.nlm.nih.gov/10970807

Zobrazit plný text záznamu

Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades

Autor: B N, Kholodenko

Publikováno v: European journal of biochemistry. 267(6)

Functional organization of signal transduction into protein phosphorylation cascades, such as the mitogen-activated protein kinase (MAPK) cascades, greatly enhances the sensitivity of cellular targets to external stimuli. The sensitivity increases mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99e0780d9ec546c8ac777fbf67231c85
https://pubmed.ncbi.nlm.nih.gov/10712587

Zobrazit plný text záznamu

Metabolic design: how to engineer a living cell to desired metabolite concentrations and fluxes

Autor: B N, Kholodenko, M, Cascante, J B, Hoek, H V, Westerhoff, J, Schwaber

Publikováno v: Biotechnology and bioengineering. 59(2)

A biotechnological aim of genetic engineering is to increase the intracellular concentration or secretion of valuable compounds, while making the other concentrations and fluxes optimal for viability and productivity. Efforts to accomplish this based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f55a40b1f6d7fc0db63b22607ee0676
https://pubmed.ncbi.nlm.nih.gov/10099334

Zobrazit plný text záznamu

A model of O2.-generation in the complex III of the electron transport chain

Autor: O V, Demin, B N, Kholodenko, V P, Skulachev

Publikováno v: Molecular and cellular biochemistry. 184(1-2)

Oxidation of semiquinone by O2 in the Q cycle is known to be one of the sources of superoxide anion (O2.-) in aerobic cells. In this paper, such a phenomenon was analyzed using the chemical kinetics model of electron transfer from succinate to cytoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a29891fcf75800d547b82e2491313c33
https://pubmed.ncbi.nlm.nih.gov/9746310

Zobrazit plný text záznamu

Subtleties in control by metabolic channelling and enzyme organization

Autor: B N, Kholodenko, J M, Rohwer, M, Cascante, H V, Westerhoff

Publikováno v: Molecular and cellular biochemistry. 184(1-2)

Because of its importance to cell function, the free-energy metabolism of the living cell is subtly and homeostatically controlled. Metabolic control analysis enables a quantitative determination of what controls the relevant fluxes. However, the ori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc63ce618226ecf88bd8dc23a29c0927
https://pubmed.ncbi.nlm.nih.gov/9746327

Zobrazit plný text záznamu

[Control of the rate of the glucokinase reaction by its elementary stages]

Autor: Ia R, Nartsissov, B N, Kholodenko

Publikováno v: Biokhimiia (Moscow, Russia). 61(7)

Limitation of an enzymatic reaction by its elemental steps is characterized by so-called control coefficients for (quasi)stationary reaction rate. Established paradigm of "limiting step" cannot describe the control of glucokinase reaction. Flux contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1296ac6bbd44368ac8b3f28732f740ae
https://pubmed.ncbi.nlm.nih.gov/9035740

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání