Zobrazeno 1 - 10
of 15
pro vyhledávání: '"B N, Dittel"'
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Gammaherpesviruses establish lifelong infections in most vertebrate species, including humans and rodents, and are associated with cancers, including B cell lymphomas. While type I and II interferon (IFN) systems of the host are critical for
Externí odkaz:
https://doaj.org/article/3e446d44ee6d433188a7516382f60df1
Autor:
B N Dittel
Publikováno v:
British Journal of Pharmacology. 153:271-276
The cannabinoid system is now recognized as a regulator of both the nervous and immune systems. Although marijuana has been used for centuries for the treatment of a variety of disorders, its therapeutic mechanisms are only now being understood. The
Publikováno v:
The Journal of Immunology. 159:4395-4402
The TCR found on CD4 T cells recognizes peptides bound to self MHC class II molecules as well as non-self MHC class II molecules. We have used the receptor on a cloned T cell line called D10.G4.1 (D10) to perform a structure-function analysis of this
Publikováno v:
The Journal of Immunology. 158:4065-4073
Engagement of a TCR by its peptide Ag bound by MHC class II molecules leads to T cell activation, resulting in proliferation and cytokine production. This agonist response can be antagonized by analogue peptides containing single amino acid substitut
Autor:
B N, Dittel, T W, LeBien
Publikováno v:
Blood. 86:2833-2841
A common sequela to allogeneic or autologous bone marrow transplantation (BMT) is a delay in the reconstitution of a functional B-cell immune response. Therefore, we examined whether the posttransplant BM microenvironment is deficient in supporting t
Autor:
B N Dittel, T W LeBien
Publikováno v:
The Journal of Immunology. 154:58-67
The growth of human B cell precursors can be supported by bone marrow (BM) stromal cells and IL-7, but the identity of the responding population is unknown. In the current study, we examined the growth characteristics of FACS-purified CD10+/CD34+/cyt
Publikováno v:
Blood. 81:2272-2282
Self-renewal and differentiation of B-cell precursors is dependent on interactions with bone marrow (BM) stromal cells and associated extracellular matrix. We have recently developed an interleukin (IL)-7- dependent, BM-derived stromal cell culture t
Autor:
B N, Dittel
Publikováno v:
British journal of pharmacology. 153(2)
The cannabinoid system is now recognized as a regulator of both the nervous and immune systems. Although marijuana has been used for centuries for the treatment of a variety of disorders, its therapeutic mechanisms are only now being understood. The
Autor:
B N, Dittel
Publikováno v:
Archivum immunologiae et therapiae experimentalis. 48(5)
The well established and characterized animal model for the human demyelinating autoimmune disease multiple sclerosis (MS) is known as experimental autoimmune encephalomyelitis (EAE). EAE is clinically characterized by focal areas of inflammation and
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(1)
Bone marrow (BM)-derived dendritic cells (DC) are potent stimulators of naive CD4+ T cell activation. Because DC are efficient at Ag processing and could potentially present self Ags, we investigated the role of DC in the presentation of an encephali