Zobrazeno 1 - 10
of 1 276
pro vyhledávání: '"B Morin"'
Autor:
Maryam Ghashghaei, Yilin Liu, James Ettles, Giuseppe Bombaci, Niveditha Ramkumar, Zongmin Liu, Leo Escano, Sandra Spencer Miko, Yerin Kim, Joseph A. Waldron, Kim Do, Kyle MacPherson, Katie A. Yuen, Thilelli Taibi, Marty Yue, Aaremish Arsalan, Zhen Jin, Glenn Edin, Aly Karsan, Gregg B. Morin, Florian Kuchenbauer, Fabiana Perna, Martin Bushell, Ly P. Vu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Protein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is poorly understood. Here, we uncovered CNOT3, a subunit of t
Externí odkaz:
https://doaj.org/article/70b7701b4c0b40d88cc303cdcb9178b8
Autor:
Ebrahim Eskandari, Gian Luca Negri, Susanna Tan, Margarita E. MacAldaz, Shengsen Ding, Justin Long, Karina Nielsen, Sandra E. Spencer, Gregg B. Morin, Connie J. Eaves
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Mechanisms that regulate cell survival and proliferation are important for both the development and homeostasis of normal tissue, and as well as for the emergence and expansion of malignant cell populations. Caspase-3 (CASP3) has long been r
Externí odkaz:
https://doaj.org/article/32b80a46192c4ea28535552dcc26b8da
Autor:
Amir Pozner, Li Li, Shiv Prakash Verma, Shuxin Wang, Jared J. Barrott, Mary L. Nelson, Jamie S. E. Yu, Gian Luca Negri, Shane Colborne, Christopher S. Hughes, Ju-Fen Zhu, Sydney L. Lambert, Lara S. Carroll, Kyllie Smith-Fry, Michael G. Stewart, Sarmishta Kannan, Bodrie Jensen, Cini M. John, Saif Sikdar, Hongrui Liu, Ngoc Ha Dang, Jennifer Bourdage, Jinxiu Li, Jeffery M. Vahrenkamp, Katelyn L. Mortenson, John S. Groundland, Rosanna Wustrack, Donna L. Senger, Franz J. Zemp, Douglas J. Mahoney, Jason Gertz, Xiaoyang Zhang, Alexander J. Lazar, Martin Hirst, Gregg B. Morin, Torsten O. Nielsen, Peter S. Shen, Kevin B. Jones
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCCs), frustrating efforts to identif
Externí odkaz:
https://doaj.org/article/22b004d19a254382bdb0a79d65c8bcf2
Autor:
Maryam Ghashghaei, Yilin Liu, James Ettles, Giuseppe Bombaci, Niveditha Ramkumar, Zongmin Liu, Leo Escano, Sandra Spencer Miko, Yerin Kim, Joseph A. Waldron, Kim Do, Kyle MacPherson, Katie A. Yuen, Thilelli Taibi, Marty Yue, Aaremish Arsalan, Zhen Jin, Glenn Edin, Aly Karsan, Gregg B. Morin, Florian Kuchenbauer, Fabiana Perna, Martin Bushell, Ly P. Vu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/0f59f076c7fc4285a49794e5de178a16
Autor:
Xianbing Zhu, Zheng Fu, Shary Y. Chen, Dionzie Ong, Giulio Aceto, Rebecca Ho, Jutta Steinberger, Anie Monast, Virginie Pilon, Eunice Li, Monica Ta, Kyle Ching, Bianca N. Adams, Gian L. Negri, Luc Choiniere, Lili Fu, Kitty Pavlakis, Patrick Pirrotte, Daina Z. Avizonis, Jeffrey Trent, Bernard E. Weissman, Ramon I. Klein Geltink, Gregg B. Morin, Morag Park, David G. Huntsman, William D. Foulkes, Yemin Wang, Sidong Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract SMARCA4 (BRG1) and SMARCA2 (BRM) are the two paralogous ATPases of the SWI/SNF chromatin remodeling complexes frequently inactivated in cancers. Cells deficient in either ATPase have been shown to depend on the remaining counterpart for surv
Externí odkaz:
https://doaj.org/article/9b0a23025ed145939844545536f59b3f
Autor:
Jennifer K. Luu, Fraser D. Johnson, Jana Jajarmi, Tianna Sihota, Rocky Shi, Daniel Lu, Dylan Farnsworth, Sandra E. Spencer, Gian Luca Negri, Gregg B. Morin, William W. Lockwood
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundLung cancer is the leading cause of cancer related death worldwide, mainly due to the late stage of disease at the time of diagnosis. Non-invasive biomarkers are needed to supplement existing screening methods to enable earlier detection an
Externí odkaz:
https://doaj.org/article/c0e77243976d436ea7b73fc2e00dc68e
Autor:
James T. Topham, Erica S. Tsang, Joanna M. Karasinska, Andrew Metcalfe, Hassan Ali, Steve E. Kalloger, Veronika Csizmok, Laura M. Williamson, Emma Titmuss, Karina Nielsen, Gian Luca Negri, Sandra E. Spencer Miko, Gun Ho Jang, Robert E. Denroche, Hui-li Wong, Grainne M. O’Kane, Richard A. Moore, Andrew J. Mungall, Jonathan M. Loree, Faiyaz Notta, Julie M. Wilson, Oliver F. Bathe, Patricia A. Tang, Rachel Goodwin, Gregg B. Morin, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J. M. Jones, David F. Schaeffer, Daniel J. Renouf
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
KRAS wildtype metastatic pancreatic ductal adenocarcinoma (mPDAC) could represent a distinct molecular entity from other PDACs. Here, the authors analyse KRAS wildtype mPDAC tumours using genomics and transcriptomics and find molecular similarities w
Externí odkaz:
https://doaj.org/article/14e83fbde8ea418ebe058f1c83ca1f44
Autor:
Karama Asleh, Gian Luca Negri, Sandra E. Spencer Miko, Shane Colborne, Christopher S. Hughes, Xiu Q. Wang, Dongxia Gao, C. Blake Gilks, Stephen K. L. Chia, Torsten O. Nielsen, Gregg B. Morin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Protein level information enables the identification of potential biomarkers and therapeutic targets for breast cancer. Here, the authors perform proteomic analysis of 2 cohorts of breast cancer surgical specimens and identify distinct subtypes, immu
Externí odkaz:
https://doaj.org/article/721684907354410998201013bf23a946
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102012- (2023)
Summary: Identification of effector targets is imperative to the characterization of the mechanisms of action of novel small molecules. Here, we describe steps to identify effector drug-protein interactions in lysates derived from cancer cell lines u
Externí odkaz:
https://doaj.org/article/b3a93d7084854adb91a91e6d7fd2a6bd
Autor:
Xiaojie Chu, Du-San Baek, Wei Li, Taras Shyp, Brian Mooney, Margaret G. Hines, Gregg B. Morin, Poul H. Sorensen, Dimiter S. Dimitrov
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein expressed in many tissues. High expression levels of ENPP1 have been observed in many cancer types such as lung cancer, ovarian cancer, and breast canc
Externí odkaz:
https://doaj.org/article/990d8462cff4464588159dfd68d9ec5f