Zobrazeno 1 - 10
of 26
pro vyhledávání: '"B M Foxwell"'
Association of the common gamma-chain with the human IL-7 receptor is modulated by T cell activation
Publikováno v:
The Journal of Immunology. 158:5727-5735
IL-7 acts on both resting and activated T cells. The functional IL-7R is reported to consist of two subunits, the ligand binding IL-7R and the common gamma-chain (gamma c chain), where IL-7R:gamma c chain association is driven solely by ligand bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c771f04795c84b0aecc391f2753189f
https://doi.org/10.4049/jimmunol.158.12.5727
https://doi.org/10.4049/jimmunol.158.12.5727
Publikováno v:
The Journal of Immunology. 151:4753-4763
Although both unstimulated and activated human T cells express high affinity IL-7R, only activated T cells can proliferate to IL-7. This responsiveness may occur as a direct result of changes in the structure of the IL-7R during T-cell activation. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60148822a5e0c74364e82896e4395807
https://doi.org/10.4049/jimmunol.151.9.4753
https://doi.org/10.4049/jimmunol.151.9.4753
Autor:
B M Foxwell, B Ruffel
Publikováno v:
Cardiology Clinics. 8:107-117
CS most probably manifests its immunosuppressive effects by inhibiting the synthesis of IL-2 and other lymphokine mRNAs during the process of T-cell activation. The detailed molecular events involved in CS's inhibition of mRNA synthesis are not known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e55428c7a4758d5f00bc619d705160b5
https://doi.org/10.1016/s0733-8651(18)30387-4
https://doi.org/10.1016/s0733-8651(18)30387-4
Publikováno v:
Current directions in autoimmunity. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c32e5d92dd9a975223a519b266a8cf2
https://pubmed.ncbi.nlm.nih.gov/11791466
https://pubmed.ncbi.nlm.nih.gov/11791466
Publikováno v:
Advances in experimental medicine and biology. 490
As we enter the 2000's it is clear that cytokine blockade is an effective therapeutic strategy for rheumatoid arthritis. In this brief review, we will review the rationale for anti TNFalpha therapy, the current status of therapy and focus on the regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a1454e00dee8cf4a955697c4f92b3e8
https://pubmed.ncbi.nlm.nih.gov/11505970
https://pubmed.ncbi.nlm.nih.gov/11505970
Publikováno v:
European journal of immunology. 31(6)
Dendritic cells (DC) are the most potent antigen-presenting cells for naive T cells, due to their high expression of MHC and costimulatory molecules, but relatively little is known about the biochemical pathways that regulate this function. We used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be1a84385800969a85e062a29e7b4c59
https://pubmed.ncbi.nlm.nih.gov/11433385
https://pubmed.ncbi.nlm.nih.gov/11433385
Publikováno v:
Immunology. 98(3)
The capacity of the immune system to respond efficiently to new antigens depends upon a continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the recirculated T‐cell pool. Factors present at the sites of naive CD4+ T‐c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df3f4ea7c8680c6eba9b2a5377a32180
https://pubmed.ncbi.nlm.nih.gov/10583600
https://pubmed.ncbi.nlm.nih.gov/10583600
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(7)
Buruli ulcer is a chronic and progressive necrotizing ulcer for which there is no medical treatment. Historically, a soluble toxin (factor) derived from the causative Mycobacterium ulcerans was found to induce the massive necrosis of skin and s.c. ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18e8ae799621526f7d26e4620b7573bf
https://pubmed.ncbi.nlm.nih.gov/10490994
https://pubmed.ncbi.nlm.nih.gov/10490994
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(5)
Macrophages are the major cytokine producers in chronic inflammatory diseases, but the biochemical pathways regulating cytokine production are poorly understood. This is because genetic tools to dissect signaling pathways cannot be used in macrophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e895ee400f7e336e5b9eebe4eb78b6e
https://pubmed.ncbi.nlm.nih.gov/10072544
https://pubmed.ncbi.nlm.nih.gov/10072544
Publikováno v:
The Journal of biological chemistry. 274(11)
We have shown recently that interleukin (IL)-2 activates the mitogen-activated protein (MAP) kinase family members p38 (HOG1/stress-activated protein kinase II) and p54 (c-Jun N-terminal kinase/stress-activated protein kinase I). Furthermore, the p38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a237edc9bb0083b887fc9de2fc2855fc
https://pubmed.ncbi.nlm.nih.gov/10066828
https://pubmed.ncbi.nlm.nih.gov/10066828