Zobrazeno 1 - 10
of 128
pro vyhledávání: '"B M Foxwell"'
Association of the common gamma-chain with the human IL-7 receptor is modulated by T cell activation
Publikováno v:
The Journal of Immunology. 158:5727-5735
IL-7 acts on both resting and activated T cells. The functional IL-7R is reported to consist of two subunits, the ligand binding IL-7R and the common gamma-chain (gamma c chain), where IL-7R:gamma c chain association is driven solely by ligand bindin
Publikováno v:
The Journal of Immunology. 151:4753-4763
Although both unstimulated and activated human T cells express high affinity IL-7R, only activated T cells can proliferate to IL-7. This responsiveness may occur as a direct result of changes in the structure of the IL-7R during T-cell activation. We
Autor:
B M Foxwell, B Ruffel
Publikováno v:
Cardiology Clinics. 8:107-117
CS most probably manifests its immunosuppressive effects by inhibiting the synthesis of IL-2 and other lymphokine mRNAs during the process of T-cell activation. The detailed molecular events involved in CS's inhibition of mRNA synthesis are not known
Publikováno v:
Current directions in autoimmunity. 3
Publikováno v:
Advances in experimental medicine and biology. 490
As we enter the 2000's it is clear that cytokine blockade is an effective therapeutic strategy for rheumatoid arthritis. In this brief review, we will review the rationale for anti TNFalpha therapy, the current status of therapy and focus on the regu
Publikováno v:
European journal of immunology. 31(6)
Dendritic cells (DC) are the most potent antigen-presenting cells for naive T cells, due to their high expression of MHC and costimulatory molecules, but relatively little is known about the biochemical pathways that regulate this function. We used t
Publikováno v:
Immunology. 98(3)
The capacity of the immune system to respond efficiently to new antigens depends upon a continuous source of naive CD4+ T cells. Such cells exit from the thymus and join the recirculated T‐cell pool. Factors present at the sites of naive CD4+ T‐c
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(7)
Buruli ulcer is a chronic and progressive necrotizing ulcer for which there is no medical treatment. Historically, a soluble toxin (factor) derived from the causative Mycobacterium ulcerans was found to induce the massive necrosis of skin and s.c. ti
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(5)
Macrophages are the major cytokine producers in chronic inflammatory diseases, but the biochemical pathways regulating cytokine production are poorly understood. This is because genetic tools to dissect signaling pathways cannot be used in macrophage
Publikováno v:
The Journal of biological chemistry. 274(11)
We have shown recently that interleukin (IL)-2 activates the mitogen-activated protein (MAP) kinase family members p38 (HOG1/stress-activated protein kinase II) and p54 (c-Jun N-terminal kinase/stress-activated protein kinase I). Furthermore, the p38