Výsledky vyhledávání - "B M, Willumsen"

The Bovine Papillomavirus E5 Oncogene Can Cooperate with ras: Identification of p21 Amino Acids Critical for Transformation by c-rasH but Not v-rasH

Autor: B M, Willumsen, W C, Vass, T J, Velu, A G, Papageorge, J T, Schiller, D R, Lowy

Publikováno v: Molecular and Cellular Biology. 11:6026-6033

We have previously used a series of insertion-deletion mutants of the mutationally activated v-rasH gene to identify several regions of the encoded protein that are dispensable for cellular transformation (B. M. Willumsen, A. G. Papageorge, H.-F. Kun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7414aaefea90f42b1a3b8749a8ee5c12
https://doi.org/10.1128/mcb.11.12.6026-6033.1991

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Rasp21 sequences opposite the nucleotide binding pocket are required for GRF-mediated nucleotide release

Autor: L, Leonardsen, J E, DeClue, H, Lybaek, D R, Lowy, B M, Willumsen

Publikováno v: Oncogene. 13(10)

The substrate requirements for the catalytic activity of the mouse Cdc25 homolog Guanine nucleotide Release Factor, GRF, were determined using the catalytic domain of GRF expressed in insect cells and E. coli expressed H-Ras mutants. We found a requi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50383b52a93a3c4c779117676d2cceb2
https://pubmed.ncbi.nlm.nih.gov/8950985

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Novel determinants of H-Ras plasma membrane localization and transformation

Autor: B M, Willumsen, A D, Cox, P A, Solski, C J, Der, J E, Buss

Publikováno v: Oncogene. 13(9)

Although it is well-established that modification of Ras by farnesol is a critical step for its membrane association and transforming activity, the contribution of other C-terminal sequences and palmitate modification to Ras localization and function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4584fa50bac064c749b9dcf0d558b478
https://pubmed.ncbi.nlm.nih.gov/8934536

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Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targets

Autor: S A, Moodie, M, Paris, E, Villafranca, P, Kirshmeier, B M, Willumsen, A, Wolfman

Publikováno v: Oncogene. 11(3)

Ras proteins function through the formation of specific complexes with Raf-1, B-raf, PI-3 kinase and RalGDS. These interactions all require Ras-GTP with an intact effector binding domain (Switch I region). We have examined the requirements of the Swi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42e0b574c38b82201ee6dde7da90be20
https://pubmed.ncbi.nlm.nih.gov/7630628

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Analysis of ras acylation sites: mutagenesis and transfection

Autor: B M, Willumsen

Publikováno v: Methods in enzymology. 250

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::90a9154aed42a5aa178f160ecebdca8b
https://pubmed.ncbi.nlm.nih.gov/7651157

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Cell transformation by ras and regulation of its protein product

Autor: D R, Lowy, M R, Johnson, J E, DeClue, H, Cen, K, Zhang, A G, Papageorge, W C, Vass, B M, Willumsen, M B, Valentine, A T, Look

Publikováno v: Ciba Foundation symposium. 176

We are studying the biological activity and regulation of mammalian Ras protein in tumours and in physiological signalling. We have shown that GAP (the GTPase-activating protein) is a potent negative regulator of normal Ras in cells. Reduction or los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51848c899bf8885880f26db17f532e74
https://pubmed.ncbi.nlm.nih.gov/8299427

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Inhibition of cell growth by lovastatin is independent of ras function

Autor: J E, DeClue, W C, Vass, A G, Papageorge, D R, Lowy, B M, Willumsen

Publikováno v: Cancer research. 51(2)

We have investigated the inhibition of cell growth by lovastatin (previously known as mevinolin), an antagonist of hydroxymethylglutaryl coenzyme A reductase which blocks the processing and membrane localization of ras proteins via inhibition of poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74a2f0278bbcdf56635b014c710a3c60
https://pubmed.ncbi.nlm.nih.gov/1985788

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Antigenic modifications associated with 'spontaneous' malignant alterations of mouse fibroblasts propagated in vitro

Autor: J, v F Kieler, Y, Oda, K, Ulrich, B M, Willumsen

Publikováno v: The Tokai journal of experimental and clinical medicine. 8(5-6)

Two types of 'spontaneous' malignant alteration in vitro of ST/a mouse lung fibroblasts (ST-L) have been observed. In contrast to cells which retained their fibroblastic appearance (R- ST-L cells), cells showing morphological signs of transformation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58af61496c46e3df7550f99761907a28
https://pubmed.ncbi.nlm.nih.gov/6100143

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Further genetic localization of the transforming sequences of the p21 v-ras gene of Harvey murine sarcoma virus

Autor: B M Willumsen, Douglas R. Lowy, Ronald W. Ellis, Edward M. Scolnick

The sequences encoding the 21-kilodalton transforming protein (p21 ras) of Harvey murine sarcoma virus have previously been localized genetically to a 1.3-kilobase segment of the viral DNA (E. H. Chang, R. W. Ellis, E. M. Scolnick, and D. R. Lowy, Sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402a77f17be162671b67990a4d431783
https://europepmc.org/articles/PMC255506/

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