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Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia

Autor: Mark P. Kamps, B M Sefton, D D Wright

Publikováno v: Molecular and Cellular Biology. 14:2429-2437

The tyrosine protein kinase p56lck transduces signals important for antigen-induced T-cell activation. In transgenic mice, p56lck is oncogenic when overexpressed or expressed as a mutant, catalytically activated enzyme. In humans, the LCK gene is loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db565d8ccb03d0d99af014dc3484dccb
https://doi.org/10.1128/mcb.14.4.2429

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Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor

Autor: Andrey S. Shaw, E D Cahir McFarland, T R Hurley, Matthew L. Thomas, B M Sefton, Jeanette T. Pingel

Publikováno v: Proceedings of the National Academy of Sciences. 90:1402-1406

Stimulation of tyrosine phosphorylation is an early and important event in antigen-induced T-cell activation. T-cell clones deficient in expression of CD45, a transmembrane protein-tyrosine-phosphatase (protein-tyrosine-phosphate phosphohydrolase, EC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee1ef90c28d9dcc3b7f4946bbac3e08
https://doi.org/10.1073/pnas.90.4.1402

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Activated lek Tyrosine Protein Kinase Stimulates AntigenIndependent Interleukin-2 Production in T Cells

Autor: K, Luo, B M, Sefton

Publikováno v: Molecular and Cellular Biology. 12:4724-4732

p56lck, a member of the src family of cytoplasmic tyrosine kinases, is expressed predominantly in T cells where it associates with the T-cell surface molecules CD4 and CD8. Mutants of CD4 and CD8 that have lost the ability to associate with p56lck no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c014458150b4550b27d657464df85aaa
https://doi.org/10.1128/mcb.12.10.4724-4732.1992

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Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin

Autor: M A Campbell, B M Sefton

Publikováno v: The EMBO Journal. 9:2125-2131

Activation of both T and B lymphocytes through their membrane receptors for antigen is known to induce breakdown of inositol phospholipids. In addition, T cell activation by antigen is accompanied by increased protein tyrosine phosphorylation of comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba6e73bee77271ff717441d78b3a4c4
https://doi.org/10.1002/j.1460-2075.1990.tb07381.x

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Autor: A S Shaw, J Chalupny, J A Whitney, C Hammond, K E Amrein, P Kavathas, B M Sefton, J K Rose

Publikováno v: Molecular and Cellular Biology. 10:1853-1862

We report that the cytoplasmic domains of the T-lymphocyte glycoproteins CD4 and CD8 alpha contain short related amino acid sequences that are involved in binding the amino-terminal domain of the intracellular tyrosine protein kinase, p56lck. Transfe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fd66a90ce45853e922c58d23a47f1b6
https://doi.org/10.1128/mcb.10.5.1853

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Autor: J Chalupny, Andrey S. Shaw, P Kavathas, B M Sefton, Craig Hammond, K E Amrein, John K. Rose, J A Whitney

Publikováno v: Molecular and Cellular Biology. 10:1853-1862

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b72f318f92726c45e2d195636a8f1e2
https://doi.org/10.1128/mcb.10.5.1853-1862.1990

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Tyrosine phosphorylation of VCP, the mammalian homologue of the Saccharomyces cerevisiae CDC48 protein, is unusually sensitive to stimulation by sodium vanadate and hydrogen peroxide

Autor: R J, Schulte, M A, Campbell, W H, Fischer, B M, Sefton

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 153(12)

A mAb produced by immunization of mice with tyrosine-phosphorylated proteins from activated B lymphocytes was found to recognize valosin-containing protein (VCP). VCP is the mammalian homologue of the Saccharomyces cerevisiae CDC48 protein and has lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7b80f2c4f8553c680d0d21fc9f062fc
https://pubmed.ncbi.nlm.nih.gov/7989749

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Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta

Autor: J A, Taddie, T R, Hurley, B S, Hardwick, B M, Sefton

Publikováno v: The Journal of biological chemistry. 269(18)

In addition to membrane immunoglobulin (mIg), the B-cell antigen receptor contains Ig-alpha/Ig-beta heterodimers that link mIg to intracellular signaling molecules. To compare the ability of the cytoplasmic domains of Ig-alpha and Ig-beta to transduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf4ef4fcaf2bdab209781a74e09bad39
https://pubmed.ncbi.nlm.nih.gov/8175787

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B-cell activation by wild type and mutant Ig-beta cytoplasmic domains

Autor: J A, Taddie, T R, Hurley, B M, Sefton

Publikováno v: Advances in experimental medicine and biology. 365

In B lymphocytes, the cytoplasmic domains of the membrane immunoglobulin-associated heterodimeric Ig-alpha and Ig-beta proteins link membrane immunoglobulin to intracellular signalling molecules. We constructed chimeric genes encoding the extracellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29edd110e598e2d23e6b775436cd8080
https://pubmed.ncbi.nlm.nih.gov/7887308

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