Výsledky vyhledávání - "B M, Michniewicz"

Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites

Autor: J S, Kaltenbronn, J P, Hudspeth, E A, Lunney, B M, Michniewicz, E D, Nicolaides, J T, Repine, W H, RoarK, M A, Stier, F J, Tinney, P K, Woo

Publikováno v: Journal of Medicinal Chemistry. 33:838-845

Renin inhibitors having 13 different isosteres connecting the P3 and P2 positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contained the hydroxyet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0c76d4b13f4db07d61b58fde4de970
https://doi.org/10.1021/jm00164a058

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Pharmacokinetics and pharmacodynamics of CI-992 following intravenous and oral administration to cynomolgus monkeys

Autor: J A, Cook, P J, Burger, B M, Michniewicz, G D, Nordblom, G W, Hicks, C, Kaplan, M J, Ryan

Publikováno v: Biopharmaceuticsdrug disposition. 19(3)

The purpose of this study was to characterize CI-992 pharmacokinetics and pharmacokinetics/pharmacodynamics (PK/PD) in sodium deplete monkeys. Panels of monkeys were administered CI-992 as a 1 h intravenous infusions (0.1 and 1 mg kg-1) or as single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::275e1991949cf58c24fc4869b170f86b
https://pubmed.ncbi.nlm.nih.gov/9570002

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Metabolic disposition of isoxicam in man, monkey, dog, and rat

Autor: P E, Borondy, B M, Michniewicz

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 12(4)

Isoxicam a new nonsteroidal antiinflammatory agent was radiolabeled with 14C at the 3-position of the benzothiazine nucleus. It was well absorbed following peroral administration to man, monkey, dog, and rat, reaching peak plasma concentrations in 4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c51fe1e3c8554ff42ce1820c9eedc1b
https://pubmed.ncbi.nlm.nih.gov/6148211

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Metabolism of a new hypolipidemic agent, 2-acetamidoethyl(p-chlorophenyl) (m-trifluoromethylphenoxy)-acetate (halofenate) in the rat, dog, rhesus monkey and man

Autor: H B, Hucker, L T, Grady, B M, Michniewicz, S C, Stauffer, S E, White, G E, Maha, F G, McMahon

Publikováno v: The Journal of pharmacology and experimental therapeutics. 179(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ae14e1dcfe5a8f5559a52c10feff150
https://pubmed.ncbi.nlm.nih.gov/5002483

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