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Deficient activation and resistance to activation-induced apoptosis of cd8+ t cells is associated with defective peripheral tolerance in nonobese diabetic mice

Autor: Jian Xin Gao, Craig Meagher, Konstantin V. Salojin, Mark J. Cameron, Wen Yang, Guillermo A. Arreaza, B. M. Gill, Terry L. Delovitch, Jian Zhang, Qing Sheng Mi

Publikováno v: Clinical Immunology. 107:103-115

Activation-induced cell death (AICD) is a mechanism of homeostasis that limits the clonal expansion of autoreactive T cells and regulates central and peripheral tolerance. In nonobese diabetic (NOD) mice, defects in central and peripheral tolerance a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ac138b5d8b4f4ce739fa6c3c8a2549
https://doi.org/10.1016/s1521-6616(03)00049-4

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Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist

Autor: Laurent Taupenot, Daniel T. O'Connor, Manjula Mahata, Seung Hyun Yoo, R J Parmer, Sushil K. Mahata, B. M. Gill, Hongjiang Wu

Publikováno v: Journal of Clinical Investigation. 100:1623-1633

Catecholamine secretory vesicle core proteins (chromogranins) contain an activity that inhibits catecholamine release, but the identity of the responsible peptide has been elusive. Size-fractionated chromogranins antagonized nicotinic cholinergic-sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d627995b86013b52820153e1c5e3b0
https://doi.org/10.1172/jci119686

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Bacterial superantigens induce down-modulation of CC chemokine responsiveness in human monocytes via an alternative chemokine ligand-independent mechanism

Autor: R, Rahimpour, G, Mitchell, M H, Khandaker, C, Kong, B, Singh, L, Xu, A, Ochi, R D, Feldman, J G, Pickering, B M, Gill, D J, Kelvin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(4)

Staphylococcal superantigens (SAgs) are very potent T cell mitogens, but they can also activate monocytes by binding directly to MHC class II molecules in a manner independent of TCR coengagement. Induction of proinflammatory cytokines and chemokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbe9105293aa9e9312b19d458d96da46
https://pubmed.ncbi.nlm.nih.gov/9973507

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Secretoneurin and chemoattractant receptor interactions

Autor: Ross D. Feldman, Bhagirath Singh, Luoling Xu, C Kong, B. M. Gill, Sushil K. Mahata, David J. Kelvin, Laurent Taupenot, R. Rahimpour, Q Xiao, Daniel T. O'Connor, T.J McDonald

Publikováno v: Journal of neuroimmunology. 88(1-2)

Secretoneurin (SN) is a 33-amino acid peptide derived from secretogranin II (chromogranin C) which induces chemotaxis of monocytes but not neutrophils. In this study, we found that SN interacted with specific cell surface binding sites on human monoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7576a750bf1f1378b71cc41689ffef6d
https://pubmed.ncbi.nlm.nih.gov/9688329

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Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice

Autor: Atsuo Ochi, B. M. Gill, Jian Zhang, Mark J. Cameron, G A Arreaza, Terry L. Delovitch, Konstantin V. Salojin

Publikováno v: The Journal of Experimental Medicine

Nonobese diabetic (NOD) mouse thymocytes are hyporesponsive to T cell antigen receptor (TCR)-mediated stimulation of proliferation, and this T cell hyporesponsiveness may be causal to the onset of autoimmune diabetes in NOD mice. We previously showed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c659fecfc2bc2bf632802c6864b34d0e
https://pubmed.ncbi.nlm.nih.gov/9294143

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Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression

Autor: H J, Wu, D J, Rozansky, R J, Parmer, B M, Gill, D T, O'Connor

Publikováno v: The Journal of biological chemistry. 266(20)

Chromogranin A is the index member of a family of acidic proteins stored and released throughout the neuroendocrine system with peptide hormones and neurotransmitters. To better understand its functional domains, its evolutionary lineage, and the bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d846363a6e11ede503b0a043ec4d77e
https://pubmed.ncbi.nlm.nih.gov/2071596

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Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism

Autor: Guillermo A. Arreaza, Daniel B. Hardy, B. M. Gill, Kevin B. Laupland, Bhagirath Singh, Mark J. Cameron, Peter Zucker, Subrata Chakrabarti, Terry L. Delovitch, Hui Yu Qin, Stephen W. Chensue, Andrés Jaramillo, Micha J. Rapoport

Publikováno v: Scopus-Elsevier

Optimal T cell responsiveness requires signaling through the T cell receptor (TCR) and CD28 costimulatory receptors. Previously, we showed that T cells from autoimmune nonobese diabetic (NOD) mice display proliferative hyporesponsiveness to TCR stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a92985c99848c1a666fb3f05ecf330
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030671243&partnerID=MN8TOARS

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