Zobrazeno 1 - 10
of 76
pro vyhledávání: '"B M, Evers"'
Publikováno v:
Oncogene
PH domain leucine-rich-repeats protein phosphatase (PHLPP) is a family of Ser/Thr protein phosphatases that serve as tumor suppressors by negatively regulating Akt. Our recent studies have demonstrated that the ubiquitin proteasome pathway has an imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3960fd9762370de026b6c18bc70b23
http://europepmc.org/articles/PMC3371166
http://europepmc.org/articles/PMC3371166
Autor:
Dai H. Chung, Joshua M. Mourot, Titilope A. Ishola, Junghee Kang, B. M. Evers, Piotr G. Rychahou
Publikováno v:
Oncogene. 27:3999-4007
Angiogenesis in neuroblastoma (NB) correlates with increased expression of vascular endothelial growth factor (VEGF) and a worse clinical outcome. Other cellular markers, such as Akt activation and MYCN amplification, are also associated with poor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a480e80f8cf9dca160c0c9daee8b6a
https://doi.org/10.1038/onc.2008.15
https://doi.org/10.1038/onc.2008.15
Publikováno v:
Cell Death & Differentiation. 15:908-919
The cellular mechanisms regulating intestinal differentiation are poorly understood. Sodium butyrate (NaBT), a short-chain fatty acid, increases p27 Kip1 expression and induces cell cycle arrest associated with intestinal cell differentiation. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abd93e1e4753e570dbe3ac5dcba0ca8
https://doi.org/10.1038/cdd.2008.2
https://doi.org/10.1038/cdd.2008.2
Publikováno v:
Oncogene. 25:43-50
Glycogen-synthase kinase-3 (GSK-3) and extracellular signal-regulated kinase (ERK) are critical downstream signaling proteins for the PI3-kinase/Akt and Ras/Raf/MEK-1 pathway, respectively, and regulate diverse cellular processes including embryonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3819e70a46a79b792e5163d164d660
https://doi.org/10.1038/sj.onc.1209004
https://doi.org/10.1038/sj.onc.1209004
Publikováno v:
Gut. 52:1472-1478
Background and aims: Determination of intracellular signalling pathways that mediate intestinal epithelial proliferation is fundamental to the understanding of the integrity and function of the intestinal tract under normal and diseased conditions. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60e27eaafda9966fbdec8a828064425
https://doi.org/10.1136/gut.52.10.1472
https://doi.org/10.1136/gut.52.10.1472
Autor:
X.-M. Wang, B. M. Evers
Publikováno v:
Digestive Diseases and Sciences. 44:33-40
The gut endocrine gene, neurotensin (NT/N), isexpressed in a strict temporally and spatially specificpattern. Utilizing a sensitive reversetranscription-polymerase chain reaction procedure, weanalyzed foregut and midgut organs for NT/N expression,det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c292ff3c2b1f9ae2412ee3ab86942937
https://doi.org/10.1023/a:1026637730050
https://doi.org/10.1023/a:1026637730050
Autor:
B. M. Evers, Mark R. Hellmich, R. M. Bonnor, J. R. T. Monson, Richard A. Ehlers, M. W. Mulholland, R. A. Hodin, Xiaofu Wang
Publikováno v:
Surgery. 124:239-247
Background: Neurotensin, an important gut hormone, binds its receptor (NTR) to stimulate proliferation of intestinal cells; the molecular mechanisms remain largely undefined. Mitogen-activated protein kinases (MAPKs) translocate to the nucleus and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::268567e19ada713c4ce511c45319f437
https://doi.org/10.1016/s0039-6060(98)70126-6
https://doi.org/10.1016/s0039-6060(98)70126-6
Autor:
Takashi Tsuchiya, T. Uchida, Izumi Shimoda, Dai H. Chung, Courtney M. Townsend, J. C. Thompson, Kazuo Sato, Jin Ishizuka, B. M. Evers, George H. Greeley, Srinivasan Rajaraman
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 266:G706-G712
The proliferative activity of gut mucosa is increased with aging. Neurotensin (NT), a tridecapeptide localized to the distal small bowel, stimulates growth of gut mucosa; the effects of aging on gut NT are not known. Young (4-mo-old), adult (1-yr-old
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f252929065ceace201005a06d5008b
https://doi.org/10.1152/ajpgi.1994.266.4.g706
https://doi.org/10.1152/ajpgi.1994.266.4.g706
Autor:
Dai H. Chung, X. Wang, B. M. Evers, K. Graves, Srinivasan Rajaraman, Courtney M. Townsend, James C. Thompson
Publikováno v:
Annals of Surgery. 218:183-188
Objective This study determined whether the neurotensin gene is expressed during early development of the liver. Summary background data Neurotensin (NT), a gut tridecapeptide localized mainly to the distal small bowel and brain of adults, is an impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5c2792bc09ba4d81203686346dffc1
https://doi.org/10.1097/00000658-199308000-00010
https://doi.org/10.1097/00000658-199308000-00010
Autor:
Courtney M. Townsend, Gopalan Srinivasan, E. B. Thompson, J. L. Lawrence, Betty H. Johnson, B. M. Evers, J. C. Thompson
Publikováno v:
Pancreas. 8:7-14
Summary Glucocorticoids are effective in the treatment of certain leukemias and lymphomas, but their effects on the growth of several solid tumors have not been determined. We report here that cortivazol (CVZ), a potent synthetic glucocorticoid, inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c0725fb3506849b36118c44bfade97
https://doi.org/10.1097/00006676-199301000-00004
https://doi.org/10.1097/00006676-199301000-00004