Zobrazeno 1 - 10
of 112
pro vyhledávání: '"B M, Babior"'
Publikováno v:
Proceedings of the National Academy of Sciences. 98:3001-3005
Activation of the phagocyte NADPH oxidase complex requires the assembly of the cytosolic factors p47 PHOX , p67 PHOX , p40 PHOX , and Rac1 or Rac2, with the membrane-bound cytochrome b 558 . Whereas the interaction of p47 PHOX with cytochrome b 558 i
Autor:
W Verbeek, H P Koeffler, B. M. Babior, J. Lekstrom-Himes, Seiji Kawano, P. M.-C. Dang, Dorothy J. Park, Peter T. Vuong, K. Xanthopoulos
Publikováno v:
Blood. 94:3141-3150
Targeted mutation of the myeloid transcription factor C/EBPɛ in mice results in gram-negative septic death at 3 to 5 months of age. This study defines the underlying molecular defects in their terminal granulocytic differentiation. The mRNA for the
Autor:
Girish M. Shah, B M Babior, R. Christopher Bleackley, Jane Turbov, Roberta A. Gottlieb, Kim Orth, W. L. Hanna, Vishva M. Dixit, Prem Seth, Christopher J. Froelich
Publikováno v:
Journal of Biological Chemistry. 271:29073-29079
Lymphocyte granule-mediated apoptosis is postulated to entail the formation of membrane pores by perforin. Then soluble granzyme reaches the cytosol either through these pores or by reparative pinocytosis. We demonstrate here that Jurkat cells bind a
Publikováno v:
Journal of Biological Chemistry. 269:6729-6734
The respiratory burst oxidase is responsible for O2- production in stimulated neutrophils and B lymphocytes. Components of this oxidase include cytochrome b558, a membrane-bound flavohemoprotein; the cytosolic polypeptides p47phox and p67phox; and on
Autor:
Jeen-Woo Park, B. M. Babior
Publikováno v:
Archives of Biochemistry and Biophysics. 306:119-124
The respiratory burst oxidase from human neutrophils is a membrane-associated enzyme that catalyzes the reduction of oxygen to O − 2 at the expense of NADPH. The oxidase is dormant in resting neutrophils, but comes to life when the cells are expose
Publikováno v:
Journal of Biological Chemistry. 267:24400-24407
It is known that in respiratory burst oxidase preparations engaged in O2- production, cytochrome b558, a characteristic oxidase component, is partly reduced. This result has been interpreted in terms of a mechanism in which cytochrome b558 functions
Autor:
Jeen-Woo Park, B M Babior
Publikováno v:
Journal of Biological Chemistry. 267:19901-19906
The respiratory burst oxidase is a multimeric enzyme responsible for O2- production by stimulated neutrophils and a few other cell types. In the resting neutrophil, the oxidase is dormant, and its subunits are distributed between the cytosol, in whic
Publikováno v:
Journal of Biological Chemistry. 267:17327-17332
Sodium dodecyl sulfate (SDS) treatment of a mixture of cytosol and plasma membranes from resting neutrophils resulted in the activation of the respiratory burst oxidase, a complicated enzyme that catalyzes the production of O2- from NADPH and oxygen.
Publikováno v:
The Journal of Immunology. 144:3066-3070
We have recently described a 40-kDa protein in peritoneal fluid that neutralized the chemotactic activity of the C fraction C5a. It was deficient in peritoneal fluids of patients suffering from familial Mediterranean fever. Further characterization o
Publikováno v:
Inflammation. 25(1)
Fish oils are known for their anti-inflammatory effects. In this paper we investigated the influence of eicosapentaenoic acid and docosahexaenoic acid (omega-3 fatty acids), as well as docosapentaenoic acid, a metabolic product of omega-3 fatty acid