Zobrazeno 1 - 8
of 8
pro vyhledávání: '"B M, Ashe"'
Autor:
S K, Shah, C P, Dorn, P E, Finke, J J, Hale, W K, Hagmann, K A, Brause, G O, Chandler, A L, Kissinger, B M, Ashe, H, Weston
Publikováno v:
Journal of Medicinal Chemistry. 35:3745-3754
A thorough analysis of the mechanism of inhibition of human leukocyte elastase (HLE) by a monocyclic beta-lactam and the mechanism of beta-lactam hydrolysis led to the preparation of potent and highly stable inhibitors of HLE. This work led to the id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451b2a8391952e9d8f09c0837d3d5f01
https://doi.org/10.1021/jm00099a003
https://doi.org/10.1021/jm00099a003
Autor:
P E, Finke, S K, Shah, D S, Fletcher, B M, Ashe, K A, Brause, G O, Chandler, P S, Dellea, K M, Hand, A L, Maycock, D G, Osinga
Publikováno v:
Journal of medicinal chemistry. 38(13)
The stereospecific synthesis of several 4-[(4-carboxyphenyl)oxy]- 3,3-dialkyl-1-[[(1-phenylalkyl)-amino]carbonyl]azetidin-2-on es 3 is described in which the C-3 alkyl groups were varied from methyl to butyl as well as allyl, benzyl and methoxymethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebdef0ce68c406e499072b2524cf1be
https://pubmed.ncbi.nlm.nih.gov/7608910
https://pubmed.ncbi.nlm.nih.gov/7608910
Publikováno v:
Journal of Biological Chemistry. 254:4027-4032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f40284ec1853878e2ea36225857e15d
https://doi.org/10.1016/s0021-9258(18)50690-6
https://doi.org/10.1016/s0021-9258(18)50690-6
Publikováno v:
Journal of medicinal chemistry. 20(11)
A series of peptides and depsipeptides containing 2-methylcarbazic acid (H-Mec-OH), the 2-aza analogue of alanine, was prepared and tested as inhibitors of pancreatic and human granulocyte elastases. A requirement for a minimum chain length as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49c51148c9e99a3b9a7491b5c121a0e4
https://pubmed.ncbi.nlm.nih.gov/915907
https://pubmed.ncbi.nlm.nih.gov/915907
Publikováno v:
The Journal of biological chemistry. 255(20)
The N-acylsaccharins and N-acylbenzoisothiazolinones form a new class of acylating inhibitors of the serine proteases with a broad spectrum of activity. However, they are unique in that they are able to differentiate between various serine proteases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6838dfd77bae917b529fa22341a0eef5
https://pubmed.ncbi.nlm.nih.gov/6776104
https://pubmed.ncbi.nlm.nih.gov/6776104
Publikováno v:
The Journal of biological chemistry. 254(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76a9aacb06b6e259132ba6342a8d193a
https://pubmed.ncbi.nlm.nih.gov/312290
https://pubmed.ncbi.nlm.nih.gov/312290
Publikováno v:
AJNR Am J Neuroradiol
The clinical course and outcome of hydrocephalus diagnosed in utero is not well understood. To approach this problem 40 cases were reviewed of intrauterine fetal hydrocephalus diagnosed with sonography, and follow-up information was obtained regardin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89cfa75f6a651ce0757afa3d2f62c8a3
https://pubmed.ncbi.nlm.nih.gov/60023
https://pubmed.ncbi.nlm.nih.gov/60023
Selective inhibition of human leukocyte elastase and bovine alpha-chymotrypsin by novel heterocycles
Publikováno v:
The Journal of biological chemistry. 256(22)
A number of N-arylbenzisothiazolinone 1,1-dioxides have been synthesized and examined for inhibitory activity against human leukocyte and porcine pancreatic elastase (EC 3.4.21.11), bovine alpha-chymotrypsin (EC 2.4.21.1), human leukocyte cathepsin G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d44a260edc78921ee219e40c16a7f44
https://pubmed.ncbi.nlm.nih.gov/6913580
https://pubmed.ncbi.nlm.nih.gov/6913580