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Cyclosporin A combined with vincristine, doxorubicin and dexamethasone (VAD) compared with VAD alone in patients with advanced refractory multiple myeloma: an EORTC-HOVON randomized phase III study (06914)

Autor: B. Lowenberg, R. Neuwirtova, C. M. Segeren, H. Dohner, H.M Lokhorst, R. Willemze, P. Sonneveld, Stefan Suciu, M. Beksac, H. Gerhartz, P. Weijermans, J van der Lelie, G. Solbu

Publikováno v: British Journal of Haematology. 115:895-902

Patients with multiple myeloma (MM) refractory to alkylating agents frequently express P-glycoprotein (Pgp), which is associated with the multidrug resistance (MDR) phenotype. We have conducted a randomized phase II/III study of the MDR reversal agen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48c25fea6ff73a859843e5283b7424ec
https://doi.org/10.1046/j.1365-2141.2001.03171.x

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A randomized study of granulocyte colony-stimulating factor applied during and after chemotherapy in patients with poor risk myelodysplastic syndromes: a report from the HOVON Cooperative Group

Autor: P. W. Wijermans, Geg Verhoef, Wlj van Putten, J van der Lelie, S Daenen, B. Lowenberg, Pieter Sonneveld, B. van der Holt, Gert J. Ossenkoppele, Leo F. Verdonck

Publikováno v: Leukemia, 13, 1207-1213. Nature Publishing Group
Leukemia, 13(8), 1207-1213. Nature Publishing Group

The purpose of this study was to determine the safety and efficacy of filgrastim as an adjunct to induction and consolidation chemotherapy in poor risk patients with myelodysplastic syndrome (MDS). Filgrastim was given both during and after chemother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91777e73dde099623afbf82a3d86bcc
https://doi.org/10.1038/sj.leu.2401478

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Specific involvement of tyrosine 764 of human granulocyte colony- stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes

Autor: JP de Koning, AM Schelen, F Dong, C van Buitenen, BM Burgering, JL Bos, B Lowenberg, IP Touw

Publikováno v: Blood. 87:132-140

Signal transduction from the granulocyte colony-stimulating factor receptor (G-CSF-R) occurs via multiple pathways, one of which involves activation of p21Ras and mitogen-activated protein kinase. The SH2 domain-containing proteins Shc and GRB2 have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78a126d07fc03afb9c52a782b825e4c2
https://doi.org/10.1182/blood.v87.1.132.bloodjournal871132

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Tumor necrosis factor regulates the expression of granulocyte- macrophage colony-stimulating factor and interleukin-3 receptors on human acute myeloid leukemia cells

Autor: O Elbaz, LM Budel, H Hoogerbrugge, IP Touw, R Delwel, LA Mahmoud, B Lowenberg

Publikováno v: Blood. 77:989-995

Tumor necrosis factor (TNF) acts as a potent enhancer of granulocyte- macrophage colony-stimulating factor (GM-CSF)- and interleukin-3 (IL-3)- induced human acute myeloid leukemia (AML) growth in vitro. We have analyzed the effects of TNF alpha on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3be6ff86f12cd12ff0d84e8818f7a72
https://doi.org/10.1182/blood.v77.5.989.bloodjournal775989

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High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome

Autor: M. E.D. Chamuleau, A. A. van de Loosdrecht, C. J. Hess, J. J.W.M. Janssen, A. Zevenbergen, R. Delwel, P. J.M. Valk, B. Lowenberg, G. J. Ossenkoppele

Publikováno v: Chamuleau, M E D, van de Loosdrecht, A A, Hess, C J, Janssen, J J W M, Zevenbergen, A, Delwel, R, Valk, P J, Lowenberg, B & Ossenkoppele, G J 2008, ' High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome ', Haematologica, vol. 93, no. 12, pp. 1894-1898 . https://doi.org/10.3324/haematol.13113
Haematologica, 93(12), 1894-1898. Ferrata Storti Foundation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9dc7d2e91b2f49f73e23e9faa9b77e
https://research.vumc.nl/en/publications/c05527f8-0724-485e-9e0b-070acaf88ac8

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Interleukin-6 (IL-6) is an intermediate in IL-1-induced proliferation of leukemic human megakaryoblasts

Autor: Luisa Mantovani, Friedhelm Herrmann, Marion A. Brach, U Schwulera, R H Mertelsmann, B Lowenberg

Publikováno v: Blood. 76:1972-1979

We have examined the in vitro effects of recombinant human (rh) interleukin-1 (IL-1) on the growth of purified megakaryoblasts obtained from patients with acute megakaryoblastic leukemia. We demonstrate that both IL-1 alpha and IL-1 beta treatment of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bd796e8cb821b17c8e6d65f0574351
https://doi.org/10.1182/blood.v76.10.1972.1972

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Common binding structure for granulocyte macrophage colony-stimulating factor and interleukin-3 on human acute myeloid leukemia cells and monocytes

Autor: LM Budel, O Elbaz, H Hoogerbrugge, R Delwel, LA Mahmoud, B Lowenberg, IP Touw

Publikováno v: Blood. 75:1439-1445

Granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) control the proliferation of human acute myeloid leukemia (AML) cells in vitro. Previously, we have shown that receptors for GM-CSF and IL-3 are often coexpressed on A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27226204b22414a55ae69b6538d98258
https://doi.org/10.1182/blood.v75.7.1439.bloodjournal7571439

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Autor: P, Sonneveld, S, Suciu, P, Weijermans, M, Beksac, R, Neuwirtova, G, Solbu, H, Lokhorst, J, van der Lelie, H, Dohner, H, Gerhartz, C M, Segeren, R, Willemze, B, Lowenberg

Publikováno v: British journal of haematology. 115(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7ee56990e99b4794a09039a18596574
https://pubmed.ncbi.nlm.nih.gov/11843823

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Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia?

Autor: van W.L.J. Putten, P. W. Wijermans, Marc Boogaerts, Urs Hess, Gmür J, Martin F. Fey, H. C. Schouten, B. Lowenberg, van der J. Lelie, Simon Daenen, Alois Gratwohl, Leo F. Verdonck, A.R. Jonkhoff, Edo Vellenga, Gregor Verhoef, Anton Hagenbeek, Peter C. Huijgens

Publikováno v: Bone Marrow Transplantation, 23, 1279-1282. Nature Publishing Group
Vellenga, E, van Putten, W L J, Boogaerts, M A, Daenen, S M G J, Verhoef, G E G, Hagenbeek, A, Jonkhoff, A R, Huijgens, P C, Verdonck, L F, van der Lelie, J, Schouten, H C & Gmur, J 1999, ' Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia? ', Bone Marrow Transplantation, vol. 23, pp. 1279-1282 . https://doi.org/10.1038/sj.bmt.1701799

The clinical use of autologous marrow transplantation in acute myeloid leukemia (AML) has been hampered by the inability to collect adequate numbers of cells after remission induction chemotherapy and the notably delayed hematopoietic regeneration fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf7662ad2c2aaf9eaca848f7146159b
https://pure.eur.nl/en/publications/20887da7-8e3d-4620-914a-194092cb9268

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