Zobrazeno 1 - 10
of 553
pro vyhledávání: '"B Lombard"'
Autor:
Taolin Yuan, Surinder Kumar, Mary E. Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J. Kunkel, Yanghan Liu, Elyse M. Petrunak, Thomas L. Saunders, Andrew P. Lieberman, Jeanne A. Stuckey, Nouri Neamati, Fathiya Al-Murshedi, Majid Alfadhel, Johannes N. Spelbrink, Richard Rodenburg, Vincent C.J. de Boer, David B. Lombard
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109991- (2024)
Summary: SIRT5 is a sirtuin deacylase that removes negatively charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basal conditions, the phenotypes of SIRT5 deficiency are quite
Externí odkaz:
https://doaj.org/article/1b3e08c25bb044469b8c3e5f02f889fd
Autor:
Jingyuan Sun, Pei Li, Honglian Gui, Laure Rittié, David B. Lombard, Katrin Rietscher, Thomas M. Magin, Qing Xie, Li Liu, M. Bishr Omary
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Keratin (K) and other intermediate filament (IF) protein mutations at conserved arginines disrupt keratin filaments into aggregates and cause human epidermolysis bullosa simplex (EBS; K14-R125C) or predispose to mouse liver injury (K18-R90C). The cha
Externí odkaz:
https://doaj.org/article/6e147275c606494284720d71e3764a41
Autor:
Angela H. Guo, Rachael Baliira, Mary E. Skinner, Surinder Kumar, Anthony Andren, Li Zhang, Robert S. Goldsmith, Shaday Michan, Norma J. Davis, Merissa W. Maccani, Sharlene M. Day, David A. Sinclair, Matthew J. Brody, Costas A. Lyssiotis, Adam B. Stein, David B. Lombard
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Heart failure (HF) is the inability of the heart to pump blood sufficiently to meet the metabolic demands of the body. HF with reduced systolic function is characterized by cardiac hypertrophy, ventricular fibrosis and remodeling, and decrea
Externí odkaz:
https://doaj.org/article/f2220b371be640c7a9e5d76ededdbcf9
Autor:
Aaron Jacobson, DO, M. Eng., Elaine Koberlein, BS, Alan Thomay, MD, Cara B Lombard, MD, Ayodele Adelanwa, MD, Dhairya A Lakhani, MD, Kelly T. Smith, MD, MS
Publikováno v:
Radiology Case Reports, Vol 17, Iss 3, Pp 710-716 (2022)
Congenital adrenal hyperplasia is an autosomal recessive disease most commonly associated with 21-hydroxylase deficiency, an enzyme integral in the biosynthesis of mineralocorticoids and glucocorticoids. We present a case of a 49-year-old male with c
Externí odkaz:
https://doaj.org/article/df0adb635d214aeb894f2ff7b1f2368d
Autor:
Matthew A. Crain, BS, Dhairya A. Lakhani, MD, Aneri B. Balar, MD, Daniel Martin, MD, Cara B Lombard, MD, Thuan-Phuong Nguyen, MD
Publikováno v:
Radiology Case Reports, Vol 16, Iss 7, Pp 1695-1699 (2021)
While germ cell testicular cancer is rare and only accounts for 1% of cancers in males, it is the most common solid malignancy among men between 14 and 44 years of age. Testicular cancer can be surgically excised by orchiectomy and is highly responsi
Externí odkaz:
https://doaj.org/article/83153fd05dea42ff80f61ef4b0fa6954
Autor:
Samuel A Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B Kemp, Nina G Steele, Megan T Hoffman, Hui-Ju Wen, Daniel Long, Sarah E Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C Nwosu, Stefanie Galban, Christopher J Halbrook, David B Lombard, David R Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Costas A Lyssiotis
Publikováno v:
eLife, Vol 11 (2022)
Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is part of the malate-aspartate shuttle, a mechanism by which cells transfer reducing equivalents from the cytosol to the mitochondria. GOT2 is a key component of mutant KRAS (KRAS*)-mediated
Externí odkaz:
https://doaj.org/article/3f6b7faa3ebf44d494617d12f6cd6c1c
Autor:
Richard A. Miller, David E. Harrison, David B. Allison, Molly Bogue, Lucas Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej Galecki, W. Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin A. Javors, Warren C. Ladiges, Francesca Macchiarini, James Nelson, Peter Reifsnyder, Nadia A. Rosenthal, Marianna Sadagurski, Adam B. Salmon, Daniel L. Smith Jr., Jessica M. Snyder, David B. Lombard, Randy Strong
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
Canagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular and kidney diseases. It also inhibits the sodium glucose transporter 2 by blocking renal reuptake and intestinal absorption of glucose. In the context of the m
Externí odkaz:
https://doaj.org/article/8346a43abd5742d2afbdcea95b0aa4d1
Autor:
Srikanth Elesela, Susan B Morris, Samanthi Narayanan, Surinder Kumar, David B Lombard, Nicholas W Lukacs
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008319 (2020)
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in children worldwide. Sirtuin 1 (SIRT1), a NAD+ dependent deacetylase, has been associated with induction of autophagy, reprogramming cellular metabolism, and
Externí odkaz:
https://doaj.org/article/23a18838d5664fb290b5aa945c0eccf1
Autor:
Benjamin Suenkel, Sergio Valente, Clemens Zwergel, Sandra Weiss, Elisabetta Di Bello, Rossella Fioravanti, Michele Aventaggiato, João A. Amorim, Neha Garg, Surinder Kumar, David B. Lombard, Tuo Hu, Pankaj K. Singh, Marco Tafani, Carlos M. Palmeira, David Sinclair, Antonello Mai, Clemens Steegborn
Publikováno v:
Journal of medicinal chemistry. 65(20)
Sirtuins are NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afd0c8aa27ecec7cea363831015b0c9
https://pubmed.ncbi.nlm.nih.gov/36228194
https://pubmed.ncbi.nlm.nih.gov/36228194
Publikováno v:
Australian and New Zealand Journal of Public Health, Vol 41, Iss 2, Pp 158-164 (2017)
Abstract Objective: Obesity is a major public health concern and women living in rural settings present a high‐risk group. With contributing factors poorly explored, we evaluated their association with weight in rural Australian women. Methods: Wom
Externí odkaz:
https://doaj.org/article/4ba73ad46da14e71bf962825af8e7b93